Inhaled Placental Mesenchymal Stromal Cell Secretome from Two- and Three-Dimensional Cell Cultures Promotes Survival and Regeneration in Acute Lung Injury Model in Mice2차원 및 3차원 세포 배양에서 흡입된 태반 중간엽 간질 세포 Secretome은 마우스의 급성 폐 손상 모델에서 생존 및 재생을 촉진합니다Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adult stem cells ALI model ARDS Cell cell spheroids cell-free therapy content coronavirus COVID-19 COVID-19 pandemic cultivation damaged death effective Effectiveness exhibited Extracellular Extracellular vesicles FIBRIN fibroblast healthcare histological immunomodulating in some Inflammatory Inflammatory diseases inhalation Inhaled investigated lung Lung inflammation Lung injury lung surfactant lung tissue Lungs management Measures mice Model morbidity and mortality Mortality Patient placental potential therapy problem proteomic regeneration regenerative respiratory distress Respiratory distress syndrome restored SARS-CoV-2 Secretome severe acute respiratory syndrome Coronavirus severe pneumonia stromal cell surfactant survival syndrome Taking therapeutic tissue regeneration [DOI] 10.3390/ijms23073417 PMC 바로가기 [Article Type] Article
Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model Research Published on 2022-03-172022-10-05 Journal: Communications Biology [Category] 바이오마커, [키워드] attribute BDNF Blood Blood brain barrier Brain brains Cell cell proliferation Concentration correlated decrease dendritic downstream Effect ENhance Express expression growth HIV intranasal intranasally memory neurons neurotoxic Newborn powerful tool promote Protein receptor reducing regenerative severity Signaling survival therapeutic tropomyosin [DOI] 10.1038/s42003-022-03177-3 [Article Type] Research
Stem cell therapy for COVID-19 pneumoniaReview Published on 2022-02-172022-10-30 Journal: Molecular Biomedicine [Category] COVID-19, [키워드] acute respiratory distress syndrome ARDS Autoimmune disease build Cell chemokines chronic inflammation Complication complications conducted contagious coronavirus coronavirus 2 COVID-19 COVID-19 symptoms Cytokines diabetes disease effective fibrosis Growth factors Hematopoietic stem cell immune system immunomodulatory properties immunomodulatory property increase Infection modulate multiple sclerosis Mutation patients Pneumonia priming Protective rapid progress reduce regenerative researcher respiratory risk SARS-CoV-2 severe inflammation Side effect Spread stem cell stem cells therapy therapy for COVID-19 tissue regeneration Treatment virus [DOI] 10.1186/s43556-021-00067-8 PMC 바로가기 [Article Type] Review
Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy유전자 요법에서 아데노 바이러스 생물학, 재조합 아데노 바이러스 및 아데노 바이러스 사용Review Published on 2021-12-142022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] adenoviral vector Adenovirus adenovirus-based best Biology Cancer Cancer cells Cancer immunotherapy Cell clinical trial clinical trials conditionally replicating adenovirus COVID-19 vaccine COVID-19 vaccines cytokine ENhance Gene therapy insertion kill m-CRA methodological Modification oncolytic virus Patients with cancer platform pluripotent stem cells promoter recombinant regenerative regenerative medicine replicate replication-defective adenoviral vector stem cell subsequent survivin therapeutic therapeutic effects therapy Tumor tumors Usage Vaccine Vaccines Viral viral replication virus wild-type [DOI] 10.3390/v13122502 PMC 바로가기 [Article Type] Review
Aging-Related Impairments to M Cells in Peyer’s Patches Coincide With Disturbances to Paneth CellsImmunology Published on 2021-12-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 adverse effect aging Antigen Cell cell differentiation cellular receptor Co-expression analysis data set distribution disturbance down-regulation Effect epithelia expression follicle-associated epithelium functional Gut Immunity IMPROVE include increase increased expression Infection intestine M cells maturation mice morbidity and mortality mucosal Paneth cell Paneth cells pathogen Peyer’s patche Peyer’s patches raise reduced reduction in regenerative respiratory tract suggested susceptibility transcription factor transcriptomics vaccination efficacy virus was increased [DOI] 10.3389/fimmu.2021.761949 PMC 바로가기 [Article Type] Immunology
mRNA, a Revolution in BiomedicineReview Published on 2021-12-052022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] addressed biomedicine carried COVID-19 pandemic effective feasibility gene editing Immunotherapy increasingly Intensive knowledge limitations Messenger RNA mRNA overcome Perspective protein replacement therapies regenerative required Research revolution target cell therapeutic therapeutic potential vaccination [DOI] 10.3390/pharmaceutics13122090 PMC 바로가기 [Article Type] Review
Immunomodulation and Regenerative Capacity of MSCs for Long-COVIDLong-COVID에 대한 MSC의 면역 조절 및 재생 능력Review Published on 2021-11-172022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ARDS Capacity clinical clinical trial clinical trials Cytokine storm death edema Effect effective drug effective drugs eventually death immunomodulation immunomodulator include Inflammation long-COVID lung lung injuries Lung injury mesenchymal stem cell Mesenchymal stem cells MSC MSCs Mutation patients with COVID-19 Post-COVID-19 patients promote provided Pulmonary edema reduce regeneration regenerative regenerative properties respiratory distress SARS-CoV-2 virus severity syndrome the disease the SARS-CoV-2 virus therapy Treatment Trial Usage [DOI] 10.3390/ijms222212421 PMC 바로가기 [Article Type] Review
Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until NowReview Published on 2021-11-102022-10-31 Journal: Cells [Category] COVID-19, [키워드] addressed application artificial intelligence Biomedical research cardiovascular cardiovascular research Cell cell replacement therapy clinical trials Combination COVID-19 degenerative disease disease modeling Drug discovery embryonic stem cells example Genome Genomics global pandemic highlight mRNA-based vaccine Patient pluripotent stem cell pluripotent stem cells regenerative Research safety pharmacology STEM tissue translation treat vessels [DOI] 10.3390/cells10113112 PMC 바로가기 [Article Type] Review
Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell TherapyCOVID-19에서 다기관 실패의 분자 메커니즘과 줄기 세포 치료의 잠재력Review Published on 2021-10-252022-09-11 Journal: Cells [Category] MERS, SARS, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 blood-brain-barrier caused Cell therapy confirmed case confirmed cases coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients damage death failure Health major organ mesenchymal molecular mechanism molecular mechanisms multi-organ failure organ system organ systems oxidative stress Potential regenerative respiratory respiratory distress SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe respiratory distress STEM stem cell Stem cell therapy stem cells systemic damage Therapeutics treating COVID-19 [DOI] 10.3390/cells10112878 PMC 바로가기 [Article Type] Review
Recent Advances of COVID-19 Modeling Based on Regenerative MedicineCell and Developmental Biology Published on 2021-10-252022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] 3D structure advance angiotensin-converting enzyme 2 animal models catch caused cell line cell population COVID-19 deficiency drug drugs Endocrine future therapeutic Health Health Organization host cell induced pluripotent stem cells Infection introduced involved liver main receptor mechanism Medicine mice Model modeling neurologic offer Organoid organoids other organ pandemic pathogenicity pathophysiology pluripotent stem cell recent receptors regenerative regenerative medicine renal systems respiratory respiratory infection responsible SARS-CoV-2 SARS-COV-2 infection stem cell subjects suggested treat Vaccine virus Wuhan, China [DOI] 10.3389/fcell.2021.683619 PMC 바로가기 [Article Type] Cell and Developmental Biology