Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cellsArticle Published on 2022-09-212022-11-15 Journal: eLife [Category] 바이오마커, 유전자 메커니즘, [키워드] alveolar alveolar epithelial cell alveolar epithelium alveolar regeneration Basal cell basal cells Biomarkers cause Cell Cell Biology Complete COVID-19 ectopic epithelial epithelial cell function IMPROVE increase independent Infection lineages lung lung parenchyma lung regeneration Lungs mechanism mice mouse mouse model Notch other organs proliferate promote promoted regenerative regenerative medicine regulate significantly stem cells suggested suppressed Tamoxifen tuft cell tuft cells viral infection Wnt [DOI] 10.7554/eLife.78217 PMC 바로가기
Potent Inactivation of Human Respiratory Viruses Including SARS-CoV-2 by a Photoactivated Self-Cleaning Regenerative Antiviral CoatingArticle Published on 2022-09-142022-11-15 Journal: ACS applied materials & interfaces [Category] SARS, 치료제, [키워드] activity antiviral activity calicivirus circulating coating Complication coronavirus COVID-19 COVID-19 pandemic curtail demonstrated Effect Evidence greatly reduce Health Human implication inactivated Including Novel viruses OC43 pandemic parainfluenza virus Personal protective equipment photoactivated regenerative virucide platform potent progression public health Radiation regenerative resource respiratory rhinovirus RNA SARS-CoV SARS-CoV 2 SARS-CoV-2 self-cleaning surfaces self-sanitizing coating shown Spread TCID Treatment upconversion nanomaterials vaccinia virus vesicular stomatitis virus virucide virus virus transmission viruses Zika virus [DOI] 10.1021/acsami.2c11653 PMC 바로가기
Immunomodulatory Mechanisms of Mesenchymal Stem Cells and Their Potential Clinical ApplicationsArticle Published on 2022-09-022022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] application Autoimmune disease Cell Characteristics chemokines clinical Clinical applications Contact contribute COVID-19 Cytokines disease Diseases Effect Engineering Factor Growth factors homing immune immune cells immune disorders Immune homeostasis immune response immunomodulation immunomodulatory immunomodulatory effect immunomodulatory property IMPROVE incurable Inflammatory diseases Inflammatory responses maintain mechanism mesenchymal stem cell mesenchymal stem cells (MSCs). MSC MSCs multifunctional Potential regenerative Regulation Secretome shown signaling molecules STEM stem cell systemic lupus erythematosus therapeutic strategy treat [DOI] 10.3390/ijms231710023 PMC 바로가기
Mesenchymal stem cell treatment for hyperactive immune response in patients with COVID-19COVID-19 환자의 과민성 면역 반응을 위한 중간엽 줄기세포 치료Review Published on 2022-09-012022-09-11 Journal: Immunotherapy [Category] COVID19(2023년), SARS, 변종, [키워드] Biomarker Biomarkers clinical clinical immunology clinical trials COVID-19 COVID-19 mortality COVID-19 patients CRP Cytokines decrease Effect effective Endothelitis epithelial cells Human immune system IL-6 immune response immune system independent invasive mesenchymal stem cell Mesenchymal stem cells MSC MSC therapy MSCs organism patients with COVID-19 potential treatment option pro-inflammatory cytokine pro-inflammatory cytokines PROTECT reduction in regenerative regimen reported Respiratory failure Safe sick stem cell stem cells systemic systemic effects therapy Treatment Trial [DOI] 10.2217/imt-2021-0245 PMC 바로가기 [Article Type] Review
Stem cell-based therapy for human diseases Reviews Published on 2022-08-062022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 임상, 치료제, [키워드] acute respiratory distress adipose Bone marrow Brain burns candidate cardiovascular conditions Cell cell type cellular phenotype clinical setting clinical trial contribute defined disease Diseases disorder disorders downstream human disease human diseases Hypothesis in vitro ISCT lineages mechanism MSC MSCs Neurological disorders Patient pluripotent stem cell progenitor cell provide pulmonary disease recent regenerative reproductive Research Society Spinal cord injury STEM stem cell Support syndrome targeted therapy therapy tissue translational treated Treatment UC-MSC umbilical [DOI] 10.1038/s41392-022-01134-4 [Article Type] Reviews
Human placenta-derived mesenchymal stem cells transplantation in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 (phase I clinical trial): safety profile assessmentClinical Trial Published on 2022-07-282022-10-05 Journal: Stem Cell Research & Therapy [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome (ARDS) administration adverse event Allogeneic Anti-inflammatory ARDS baseline cause caused Cell Cell therapy clinical Clinical sign clinical trial control group coronavirus COVID-19 COVID-19 pandemic death in COVID-19 demonstrated distress dose Efficacy enrolled evaluate evaluated feasible Health Hospitalization Human immunomodulatory injection intensive care intravenous Intravenous injection intravenously laboratory parameter Laboratory test mesenchymal stem cell morbidity and mortality not significantly different oxygen saturation participant Patient patients patients with ARDS patients with COVID-19 Phase I PL-MSC PL-MSCs Placenta mesenchymal stem cells (PL-MSC). protocol regenerative registry repeated Safe Safety assessment safety profile serum single dose standard treatment stem cell subject syndrome Treatment treatment group two group [DOI] 10.1186/s13287-022-02953-6 PMC 바로가기 [Article Type] Clinical Trial
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species노출 방식은 여러 비인간 영장류 종에서 바이러스 역학에 영향을 미치지만 COVID-19의 호흡기 결과에는 영향을 미치지 않습니다Article Published on 2022-07-052022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] aerosol exposure African African green monkeys AGM AGMs animal model animal models ARDS change Characteristics Chlorocebus clinical clinical response Clinical sign Clinical signs Cohort conserved COVID-19 COVID-19 disease cytokine response demonstrated demonstration develop expand exposure functional greater include infected with SARS-CoV-2 Infection influence intranasal lack lung damage magnitude Medical countermeasures mucosal mucosal exposure myeloid cell Novel coronavirus novel coronavirus SARS-CoV-2 outcome pandemic status Pathogenesis Pathologies pleuritis Pulmonary pathology reached regenerative Research rhesus rhesus macaques route SARS-COV-2 infection severe disease small particle aerosol species tested therapeutic utility variants variants of concern viral kinetics Viral load [DOI] 10.1371/journal.ppat.1010618 PMC 바로가기 [Article Type] Article
Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations폐 내피 세포의 단일 세포 전사체 프로파일링은 동적 염증 및 재생 하위 집단을 식별합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Activation Bacterial infections baseline Cell Clustering defined demonstrated division endothelial endothelial cells Endothelium expression Gene Expression H1N1 H1N1 influenza H1N1 influenza virus heterogeneity identify immune response gene immune response genes increased expression infected with SARS-CoV-2 Infectious disease Inflammatory inflammatory lung injury inflammatory signaling Influenza Injury labor limit LPS lung lung endothelial Lung injury MHC gene MHC genes murine organ overexpression Pathway analysis performed phenotypic prevented proliferative promote Pulmonology regeneration regenerative respond Seurat single-cell single-cell RNA-seq Sox17 subpopulation targeted therapy transcriptomic Vascular vascular bed vascular endothelial cell vascular endothelial cells virus [DOI] 10.1172/jci.insight.158079 PMC 바로가기 [Article Type] Article
Extracellular vesicles in kidney disease Reviews Published on 2022-05-312022-10-05 Journal: Nature reviews. Nephrology [Category] 바이오마커, [키워드] addition administration Alter amplification body fluids candidate Cell cell type cell-to-cell communication chronic kidney diseases circulating diagnostic Efficacy Evidence extracellular vesicle fibrosis gene expression profile glomerular Increasing Inflammation investigated involved kidney kidney damage Kidney disease majority mechanism modulate molecular organ pathology pathophysiological preclinical data prognostic promote reduce reflect regenerative released robust Standardization stem cell target cells thought tubular cell urinary Vesicle [DOI] 10.1038/s41581-022-00586-9 [Article Type] Reviews
Biocompatible Conductive Hydrogels: Applications in the Field of Biomedicine생체 적합성 전도성 하이드로 겔 : 생체 의학 분야의 응용Review Published on 2022-04-212022-08-31 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] application biocompatibility biological properties biomedical applications biomedicine Cell cell growth Characteristics complex complex system conductive hydrogels COVID-19 drug delivery systems electrical electrical conductivity environmental condition environmental conditions field functional gel growth maintain organs pandemic physical preparation materials regenerative regenerative medicine stability substrate synthetic techniques. tissue [DOI] 10.3390/ijms23094578 PMC 바로가기 [Article Type] Review