regulator – Page 2 – Communicable Diseases Research

High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion

COVID-19의 고해상도 혈청 프로테옴 궤적은 환자별 혈청 전환을 나타냅니다

Article

Published on 2021-07-072022-09-11
Journal: EMBO Molecular Medicine
[Category] MERS, SARS, 유전자 메커니즘, 진단,

Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients

코로나19 환자에서 ACE2, 가용성 ACE2, 안지오텐신 I, 안지오텐신 II 및 안지오텐신-(1-7)의 발현이 조절됨

Immunology

Published on 2021-06-142022-09-11
Journal: Frontiers in Immunology
[Category] MERS, 바이오마커,

[키워드] ACE2 ACE2 (Angiotensin Converting Enzyme-2) ACE2 expression ACE2 gene ACE2 mRNA ACE2 protein adverse effect adverse effects Affect alveolar Ang II angiotensin angiotensin I Angiotensin II binding blood cell Blood cells blood pressure blood pressure homeostasis Cell cell types cells circulating Concentration consequence coronavirus COVID-19 COVID-19 patient COVID-19 patients dysregulation enzyme etiological agent Evidence Express expression healthy controls healthy volunteers hypertension less lower expression membrane Monocytes outcome plasma plasma concentration Plasma levels pneumocyte Prevent proteolysis regulator Renin – Angiotensin – Aldosterone System sACE2 SARS – CoV – 2 SARS-CoV-2 SARS-CoV-2-infected patients soluble ACE2 the SARS-CoV-2 These data Trigger Variation variations Viral virus
[DOI] 10.3389/fimmu.2021.625732 PMC 바로가기 [Article Type] Immunology

Alcohol Consumption Is Associated with Poor Prognosis in Obese Patients with COVID-19: A Mendelian Randomization Study Using UK Biobank

알코올 소비는 COVID-19에 걸린 비만 환자의 나쁜 예후와 관련이 있습니다: UK Biobank를 사용한 멘델식 무작위 배정 연구

Clinical Trial

Published on 2021-05-102022-08-13
Journal: Nutrients
[Category] SARS, 변종, 임상,

[키워드] 95% CI Acute and chronic alcohol abuse acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Adaptive immune response ADH1B adverse effect adverse effects adverse impact alcohol Alcohol Abuse alcohol consumption Alcohol Dehydrogenase allele Analysis applied association average carrier Clinical outcome conducted Consumption coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patients death death in COVID-19 dehydrogenase Evidence family GCKR Genetic variant glucokinase heavy drinking higher risk Infection instrumental variable instrumental variables Logistic regression member mendelian randomization Mendelian randomization analyses Mendelian randomization analysis Mortality obesity outcome outcomes participant Participants Patient patients patients with COVID-19 patients with obesity Poor positive progression promote reduced regulator respiratory risk risk of death SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 SLC39A8 Solute susceptibility tested UK biobank
[DOI] 10.3390/nu13051592 PMC 바로가기 [Article Type] Clinical Trial

COVID-19 engages clinical markers for the management of cancer and cancer-relevant regulators of cell proliferation, death, migration, and immune response

COVID-19는 암 관리 및 세포 증식, 사멸, 이동 및 면역 반응의 암 관련 조절자를 위한 임상 마커를 사용합니다.

Article

Published on 2021-03-042022-08-31
Journal: Scientific Reports
[Category] SARS, 바이오마커, 치료법,

[키워드] biological processe biological processes Cancer cancer patient Cancer patients Cancer therapy Cell cell proliferation clinical clinical decision clinical marker clinical markers clinical observations COVID-19 death Diagnosis diagnostic Diversity EGF endothelial engage Engagement epidemiological epithelial FGF immune response immune system immune system cells infected with SARS-CoV-2 initiated Intersection management marker mechanism Migration modifications network network analysis observation pathway Pathways predicted Prognosis provide rationale regulator Regulatory Regulatory networks retrieved SARS-CoV-2 smooth muscle Support Symptom TGFβ Treatment Tumor tumor suppressors tumorigenesis understanding VEGF virus was used
[DOI] 10.1038/s41598-021-84780-y PMC 바로가기 [Article Type] Article

TOR functions as a molecular switch connecting an iron cue with host innate defense against bacterial infection

TOR는 철 신호를 박테리아 감염에 대한 숙주의 타고난 방어와 연결하는 분자 스위치로 기능합니다.

Research Article

Published on 2021-03-032022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activated activating autophagy Bacterial infection Bacterial infections Caenorhabditis elegan Caenorhabditis elegans conditions defend Defense Degradation essential nutrient ferritin function Host host defense host innate immunity host-pathogen interactions hosts increase in Increased induce Infection iron modulate modulating molecular molecular mechanism organism pathogen pathogenic pathogenic bacterium Pathogens PROTECT Protein protein level Rapamycin regulator required reveal Salmonella subunit suppresse suppressed survival target transcript transcripts transition turn upregulated worm worms
[DOI] 10.1371/journal.pgen.1009383 PMC 바로가기 [Article Type] Research Article

Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19

COVID-19에서 염증성 대식세포 반응의 잠재적 조절자로서의 전문화된 해결 중재자

Review

Published on 2021-02-242022-09-12
Journal: Frontiers in Immunology
[Category] MERS, 진단,

Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective

Inflammasome 신호 전달의 주요 조절자로서의 칸나비노이드: 현재의 관점

Review

Published on 2021-01-282022-09-11
Journal: Frontiers in Immunology
[Category] MERS, SARS, 치료기술, 치료제,

[키워드] activated Anti-inflammatory cannabidiol cannabinoid cannabinoids cannabis caspase caspase-1 chronic inflammatory diseases chronic inflammatory disorder chronic inflammatory disorders concerning coronavirus coronavirus disease COVID-19 current Cytokines cytoplasmic Delta-9 tetrahydrocannabinol detect drug elements etiology Evidence human disease human diseases human disorder IL-18 indicate Inflammasome inflammasome activation inflammasome signaling inflammasomes Inflammatory Inflammatory diseases inflammatory disorders inflammatory signaling ingredient Innate immunity interleukin marijuana maturation mechanism Medical conditions microbial milieu modulating pandemic pathophysiology plant pro-inflammatory cytokines promote protein complex protein complexes pyroptosis referred to Regulation regulator Research secretion Support tetrahydrocannabinol Treatment variety
[DOI] 10.3389/fimmu.2020.613613 PMC 바로가기 [Article Type] Review

Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

신호 전달 경로 내 및 사이의 다면발광 및 상위성은 진균 독성의 유전적 구조를 정의합니다

Research Article

Published on 2021-01-252022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Affect amphotericin B Analysis antifungal drug resistance approach Author avirulent body temperature CAMP cascade Cell Cell signaling cellular cellular response Cellular responses characterization Combination complex component contribute cross Cryptococcal disease Cryptococcus cyclic AMP disease drug susceptibility drugs ENCODE epistatic interaction Europe Extracellular fungal Genes Genetic genetic architecture genetic difference genetic differences Genetic variation glycerol growth highlight human body Infection information isolate kinase Lineage locus make up mapping microbial modify molecular nucleotide osmolarity osmotic oxidative oxidative stress oxidative stress resistance pathogen pathogenicity Pathogens pathway phenotypic phenotypic variation physiological response pleiotropic polysaccharide capsule progeny promote protein kinase QTL Quantitative quantitative trait locus regulate regulator sensitivity Signal transduction Signaling signaling pathway strain Strains Stress temperate climates thought Tolerance traits underlie Variation virulence virulent
[DOI] 10.1371/journal.pgen.1009313 PMC 바로가기 [Article Type] Research Article

Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a

분자 역학은 CRISPR-Cas12a의 활성화를 유발하는 DNA 유도 동적 스위치를 보여줍니다

Article

Published on 2020-12-282022-09-11
Journal: Journal of Chemical Information and Modeling
[Category] SARS, 치료기술, 치료제,

A Scientific Rationale for Using Cystic Fibrosis Transmembrane Conductance Regulator Therapeutics in COVID-19 Patients

Physiology

Published on 2020-11-042022-10-31
Journal: Frontiers in Physiology
[Category] COVID-19,