regulatory network – Page 2 – Communicable Diseases Research

The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways

Candida glabrata UPC2A 전사 인자는 항진균제 약물 내성 경로의 글로벌 조절 인자입니다.

Research Article

Published on 2021-09-302022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Inferring SARS-CoV-2 functional genomics from viral transcriptome with identification of potential antiviral drugs and therapeutic targets

Letter to the Editor

Published on 2021-09-082022-11-01
Journal: Cell & Bioscience [Category] COVID-19,

The CovR regulatory network drives the evolution of Group B Streptococcus virulence

COVR 규제 네트워크는 그룹 B Streptococcus 독성의 진화를 주도합니다.

Research Article

Published on 2021-09-072022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation adhesin adhesins Adults Analysis architecture Bacterial binding characterized clinical isolates clone commensal bacterium Comparative Comparative analysis complex cross endothelial epithelial Evolution expression Factor functional Genes Genome group healthy heterogeneity Host impair infections Interaction intestinal invasive isolate Lineage loci majority master regulator Meningitis Mutation Neonatal neonatal meningitis occur opportunistic pathogen pan-genome pathogen Pathologies phenotypic Phosphorylation plasticity promoters Regulation Regulatory regulatory network responsible Signaling signaling pathway specific diseases Streptococcus Streptococcus agalactiae suggested surface protein surface proteins Transcriptome type strain Variability virulence virulence factors virulence gene virulence genes wild type wild type strain
[DOI] 10.1371/journal.pgen.1009761 PMC 바로가기 [Article Type] Research Article

Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection

SARS-CoV-2 감염에 대한 유전자 대 유전자 조절 네트워크의 동적 변화

Article

Published on 2021-05-272022-09-10
Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 치료제,

SARS-CoV-2/human interactome reveals ACE2 locus crosstalk with the immune regulatory network in the host

SARS-CoV-2/인간 상호작용체는 숙주의 면역 조절 네트워크와 ACE2 유전자좌 누화를 밝힙니다

Article

Published on 2021-02-192022-09-11
Journal: Pathogens and disease [Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 receptor ACE2/AGT-axis activating Activation acute respiratory syndrome adrenal gland Altered angiotensin angiotensin-converting enzyme 2 approach axis binding blood pressure body tissues carboxypeptidase Cell cell cycle changes in Complication coronavirus COVID-19 cytokine database determine develop event gene expression profile globe Health help Host host immune system host protein Human human Angiotensin-converting enzyme human lung human tissue immune immune modulation immune response in viral Infection infection site Interaction involved kidneys Lineage locus lung Lungs mechanism mechanisms modulate molecular network Occurrence organs pancreas Placenta Primary infection Protein Proteins proteomic RAS receptor regulated regulatory network Renin renin-angiotensin system Replication respiratory reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Severe acute respiratory syndrome Signal transduction small intestine Spike protein Testis tissues vascular remodelling Viral viral infection viral spike protein
[DOI] 10.1093/femspd/ftab005 PMC 바로가기 [Article Type] Article

Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19

세로 전사체 분석은 COVID-19에서 회복하는 동안 강력한 T 세포 면역을 보여줍니다

Article

Published on 2020-12-242022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Analysis AP-1 Clinical features Clinical stages convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 creation differentially expressed differentiation disease downregulated driven by event Genome informatics Humoral immunity immune protection immune regulation immune response immune responses Immunity indicated Infectious diseases long non-coding RNA longitudinal Messenger RNA messenger RNAs microRNA MicroRNAs miRNAs mononuclear cell mRNAs occurred Patient PBMC performed Peripheral blood regulatory network rehabilitation respiratory RNA sequencing robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway significantly T cell T-cell activation Transcriptome Treatment type I interferon type I interferon response understanding
[DOI] 10.1038/s41392-020-00457-4 PMC 바로가기 [Article Type] Article

Transcriptome analysis reveals modulation of the STAT family in PEDV-infected IPEC-J2 cells

Research Article

Published on 2020-12-142022-10-28
Journal: BMC Genomics [Category] Coronavirus, MERS,

[키워드] Analysis analyzed binding site Cell cells classical cytokine receptor described differentially expressed differentially expressed gene disease downregulated Enhancing epidemic diarrhea epithelial cell line examined FIVE Genes Genetic Host host cell host response immune response imperative Infection Inflammatory response influenza A Interaction intestinal involved IPEC-J2 knowledge modulation molecular mechanism Pathogenesis Pathways PEDV promoter region regulatory network response Result reveal RNA-Seq sequence significantly STAT STAT family suggested supplementary material TNF signaling Transcription transcription factor transcriptome analysis transcriptomic transcriptomic analysis transcriptomic profile upregulated virus
[DOI] 10.1186/s12864-020-07306-2 PMC 바로가기 [Article Type] Research Article

A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection

네트워크 기반 분석은 SARS-CoV-2 감염에서 사이토카인 폭풍과 바이러스를 억제하는 비타민 D의 기본 메커니즘을 보여줍니다.

Immunology

Published on 2020-12-092022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료제,

[키워드] 2019 activating Antiviral antiviral response approach bind bioinformatics cause Cell Cluster Combination coronavirus COVID-19 Critical cytokine Cytokine storm Cytokines Defense depth analysis differentially expressed epithelial experimental validation expression Extensive fibrosis finding Functional enrichment analysis generate Genes highest host gene host genes host response human immune response IFN-α immune in-depth analysis infect Inflammatory Inflammatory response inhibit initiate ISGs leads Lower respiratory tract Lung fibrosis MCODE score mechanism molecular mechanism NFkB1 NHBE Organ failure pandemic pathway Pathways Patient potential mechanism POU2F2 pro-inflammatory cytokine pro-inflammatory cytokines protein-protein interaction receptor reducing referred to Regulation regulatory network respiratory Result resulting RNA sequencing robust antiviral response SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patients severe pneumonia Signaling signaling pathway STAT Stat1 STAT2 STAT3 storm suggested Suppressing Systems biology the cells the cytokine storm TNF transcription factor transcription factors Transcriptome Tuberculosis up-regulated Viral viral infection Vitamin Vitamin D were used
[DOI] 10.3389/fimmu.2020.590459 PMC 바로가기 [Article Type] Immunology

nSARS-Cov-2, pulmonary edema and thrombosis: possible molecular insights using miRNA-gene circuits in regulatory networks

Research

Published on 2020-10-302022-10-31
Journal: Exrna [Category] COVID-19,

[키워드] accompany Antigen presentation antigen-presentation approach Cell coronavirus 2 Diseases disorder drugs edema Factor Features Feed forward loops FFLs identify Infection Inflammatory response information loop miRNA miRNA coregulatory networks molecular molecular mechanism motif nSARS-CoV-2 pandemic pathophysiology pathway pulmonary disease Pulmonary edema regulate regulatory circuit regulatory network Research respiratory Result Signaling signaling pathway signaling pathways similarity Spread symptomatic targets TGF the disease thromboembolic thrombosis trajectory unique vaccine candidate viral replication virus virus spike protein while
[DOI] 10.1186/s41544-020-00057-y PMC 바로가기 [Article Type] Research

Identification of Novel SARS-CoV-2 Drug Targets by Host MicroRNAs and Transcription Factors Co-regulatory Interaction Network Analysis

호스트 MicroRNA 및 전사 인자 공동 조절 상호 작용 네트워크 분석에 의한 새로운 SARS-CoV-2 약물 표적 식별

Genetics

Published on 2020-10-142022-08-13
Journal: Frontiers in Genetics [Category] 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Analysis Anti-viral anti-viral activity Anti-viral drugs anti-viral miRNAs approach biological processes coronavirus DNMT1 downregulated drug drug target Epigenetic epigenetic modification Factor FIVE GDF1 Gene Expression gene regulatory network Genes HMOX1 Host host gene host miRNA host response host responses host–microRNA hsa-miR-1-3p hsa-miR-15a-5p hsa-miR-17-5p hsa-miR-199a-3p hsa-miR-20a-5p hsa-miR-429 hub genes human miRNA human miRNAs identification identify immune system include Interaction interferon involved ITGB1 mechanism miRNA miRNAs Modification modulation network novel other respiratory virus Other respiratory viruses PLAT Protein–protein interaction Regulatory regulatory network reported repression respiratory Respiratory disease respiratory diseases SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus T-cell differentiation target TFS transcription factor transcription factors understanding unique virulence virus virus infection virus replication viruses
[DOI] 10.3389/fgene.2020.571274 PMC 바로가기 [Article Type] Genetics