Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug propertiesResearch Article Published on 2022-01-112022-10-30 Journal: JCI Insight [Category] COVID-19, [키워드] active against acute respiratory syndrome administration Antiviral antiviral activity arenaviruses cell types clinical development Combination combination therapy coronavirus coronavirus disease COVID-19 distribution drug therapy drug-resistant effective Efficacy filoviruses greater half-maximal inhibitory concentration help Human humans in vitro investigated metabolism patients phylogenetically pursuit Remdesivir replicative SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant Support suppress suppressed tested therapeutic Therapeutics Toxicity variant variants Viremia viruses [DOI] 10.1172/jci.insight.153165 PMC 바로가기 [Article Type] Research Article
Emerging SARS-CoV-2 Genotypes Show Different Replication Patterns in Human Pulmonary and Intestinal Epithelial CellsArticle Published on 2021-12-232022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] B.1.1.7 B.1.351 Caco-2 cells calu-3 cells cell line cell lines characterisation Clinical practice coronavirus 2 COVID-19 culture supernatant Effectiveness Epidemiology evaluated Genome Genotype Human humans incidence infected cells intestinal epithelium isolate Lineage P.1 pandemic pattern pulmonary released replicate Replication replicative representing respiratory RT-qPCR SARS-CoV-2 SARS-CoV-2 isolate show Spread transmission rate Vaccines variants variants of concern Vero E6 cell VERO E6 cells viral culture viral isolate Viral variants virus virus genotype Wuhan, China [DOI] 10.3390/v14010023 PMC 바로가기 [Article Type] Article
Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian PeninsulaCoronaviruses Published on 2021-12-172022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, [키워드] adaptive alpaca Amino acid amino acid substitution Analysis animal Antiviral Arabian Peninsula binding caused clade decrease difference double-stranded elicited enhanced Epidemic explain Frame hosts Human Hypothesis IFN IFN response immunological parameters in vivo infecting Infection inoculated interferon-stimulated gene ISGs MERS-CoV Middle East Middle East respiratory syndrome Coronavirus moderate motif nasal nasal mucosa orf4a post inoculation Protein Replication replicative reported respiratory syndrome coronavirus respiratory tract RNA S proteins strain subsequent Transcription Transmission variant viral loads viral shedding Virological virus while [DOI] 10.1080/22221751.2021.2019559 PMC 바로가기 [Article Type] Coronaviruses
Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples감염성 예측: 임상 샘플에서 배양 가능한 SARS-CoV-2를 검출하기 위한 4가지 PCR 기반 분석 비교Article Published on 2021-12-132022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] addition analytical sensitivity caused Cell cell type clinical clinical sample clinical samples correlated COVID‐19 CPE Culture Cutoff Cytopathic effect dependent on detect diagnostic diagnostic testing effective expressing faster Genome identify infected individuals infectious Infectious virus Isolation Live virus Methods & Resources Microbiology, Virology & Host Pathogen Interaction negative‐strand pandemic parental predict replicative RNA RT‐PCR RT–PCR SARS‐CoV‐2 SARS‐CoV‐2 sgRNA significantly specimen subgenomic subset tested the cell TMRPSS2 transcriptional transcripts Vero E6 Vero E6 cell VERO E6 cells Viral Viral RNA viral RNA species viral RNA specy virus [DOI] 10.15252/emmm.202115290 PMC 바로가기 [Article Type] Article
The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshiftingArticle Published on 2021-12-102022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, [키워드] Alter Antiviral Cell cellular dissect element enzyme expand Factor Frame frameshift Gene Expression Host identify impair in vitro inhibit inhibitor interact interfere isoform occur overexpression Protein proteome Regulation replicative RNA SARS-CoV-2 SARS-CoV-2 infected cells the SARS-CoV-2 These data transcript translation viral life cycle viral replication virulence virus viruses ZAP [DOI] 10.1038/s41467-021-27431-0 PMC 바로가기 [Article Type] Article
A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortalityCOVID-19 사망률을 줄이기 위한 바이러스 중심 치료와 환자 중심 치료 간의 비교Review Published on 2021-12-012022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 치료제, [키워드] ACE2 acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aging angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-inflammatory treatment anti-inflammatory treatments Antiviral antivirals bind caused changed Comorbidities coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality death rate death rates Dexamethasone dysfunction Effectiveness effort elderly elderly patients enzyme explain hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients Infection inhibit limit majority Mas receptor Mortality Patient patients patients hospitalized reduce Renin renin-angiotensin system replicative required respiratory Respiratory failure SARS-CoV-2 SARS-CoV-2 viral load Scientific community severe acute respiratory syndrome Coronavirus severe COVID-19 symptoms severity severity of symptom Spike protein syndrome the disease the spike protein therapeutic therapeutic option therapeutic options therapeutic strategy those with comorbidity Tocilizumab Treatment Viral Viral load virus with COVID-19 [DOI] 10.1080/22221751.2021.2006579 PMC 바로가기 [Article Type] Review
Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication423 Published on 2021-11-292022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome affecting Analysis approach Betacoronavirus betacoronaviruses biochemical C-terminal catalytic cellular characterized conserved coronavirus CoV CoVs Critical defined Degradation develop domain drugs enzymatic activity enzyme Exoribonuclease feature genomes highlight host cell cytoplasm identify in silico in viral inhibitor innate immune involved MERS-CoV Messenger RNA methyltransferase Middle East MOST mRNA mRNA capping mRNAs Mutation N-terminal nonstructural protein 14 nsp14 nsp14-ExoN pandemic phenotype PROTECT replicate Replication replicative residue reveal RNA synthesis SARS-CoV SARS-CoV-2 selected Significance site-directed mutagenesis Substitution subunit syndrome targets tested translation unique viability Virological virus was used yielding [DOI] 10.1073/pnas.2108709118 PMC 바로가기 [Article Type] 423
Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARS-CoV-2 Infection In VitroArticle Published on 2021-11-192022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] acute respiratory syndrome analyzed anti-inflammatory property antiviral activity Antiviral effect antiviral efficacy antivirals Combined coronavirus COVID-19 cytokine production demonstrated Efficacy evaluated expression IL-6 Infection Influenza Influenza virus inhibit inhibiting inhibitory effect mechanism Micronutrient micronutrients Polydatin polyphenol polyphenols post infection precursor reduced Replication replicative respiratory virus Respiratory virus infections resveratrol role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections significantly tested Treatment Vero E6 cell Viral protein virus virus-infected cells [DOI] 10.3390/biomedicines9111721 PMC 바로가기 [Article Type] Article
Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral MechanismsCurcumin은 다중 항바이러스 메커니즘을 통해 Vero E6 세포의 시험관 내 SARS-CoV-2 감염을 억제합니다Article Published on 2021-11-162022-09-10 Journal: Molecules [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] addition Affect anti-inflammatory effect anti-inflammatory property Antiviral antiviral activity Antiviral effect COVID-19 Curcumin Cytokines cytotoxicity D614G D614G strain delta variant ELISA evaluated exhibit exhibited IL-1β IL-6 IL-8 immune response in vitro independent Infection Inflammation inhibited investigated mononuclear cell mononuclear cells MTT Multiple PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Plaque assay Post-infection pro-inflammatory cytokine pro-inflammatory cytokines qPCR quantified released replicative required SARS-CoV-2 SARS-COV-2 infection scarcity the SARS-CoV-2 Therapeutic approach therapeutic approaches to define Treatment treatment strategy triggered Vero E6 VERO E6 cells Viral viral titer virucidal were used [DOI] 10.3390/molecules26226900 PMC 바로가기 [Article Type] Article
Basic Predictive Risk Factors for Cytokine Storms in COVID-19 PatientsCOVID-19 환자의 사이토카인 폭풍에 대한 기본 예측 위험 요소Observational Study Published on 2021-11-102022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 임상, [키워드] Absolute lymphocyte count acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Anti-inflammatory therapy basic C-reactive protein caused Chest chest computed tomographic city clinical and biochemical prognostic factors clinical assessment coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient COVID-19 patients Critical CRP cytokine Cytokine storm Cytokine storms Cytokines D-dimer Diagnosis disease dysregulation ECG Electrocardiography Factor ferritin Gender greater high risk identify IL-6 IL-6 levels immune dysregulation Inflammatory response institution interleukin lab laboratory biomarker laboratory biomarkers Lactate lactate dehydrogenase LDH leads less lymphocyte male material medical record medical records men objective overproduction Pathogenesis Patient patients patients with moderate performed positive test result prognostic prognostic biomarker Prognostic biomarkers prognostic scale proinflammatory cytokines replicative respiratory Result risk risk factor RNA routine clinical practice SARS-CoV-2 score serum serum CRP Serum IL-6 severe disease state storm suggested test result Treatment two groups was used women [DOI] 10.3389/fimmu.2021.745515 PMC 바로가기 [Article Type] Observational Study