replicative – Communicable Diseases Research

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

SARS-CoV-2 Omicron은 세포 진입 경로가 변경된 면역 탈출 변종입니다.

Article

Published on 2022-08-012022-09-11
Journal: Nature Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단,

Senescent endothelial cells are predisposed to SARS-CoV-2 infection and subsequent endothelial dysfunction

노화 내피 세포는 SARS-CoV-2 감염 및 후속 내피 기능 장애에 걸리기 쉽습니다.

Article

Published on 2022-07-252022-09-12
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단,

Low-frequency variants in mildly symptomatic vaccine breakthrough infections presents a doubled-edged sword

경미한 증상이 있는 백신 획기적인 감염의 저주파 변이는 양날의 검을 제시합니다

Article

Published on 2022-07-012022-09-11
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 association BNT162b2 case study characterized coronavirus Critical Efficacy Epidemiology epitope Epitopes Evolution Genetic Genetic variation genetics highlight immune individual Infection L18F Mutation Pfizer Phylogenetic question raised reduced reducing replicative SARS Coronavirus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe symptoms Symptom symptomatic the vaccine Transmission vaccination Vaccination Status Vaccine vaccine breakthrough infection Vaccines variant variants of concern virus virus classification VoC VOCs widespread
[DOI] 10.1002/jmv.27726 PMC 바로가기 [Article Type] Article

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2

Research

Published on 2022-05-162022-10-05
Journal: Nature [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제,

The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune response

SARS-CoV-2 감염 동안 lncRNA, RNA 결합 단백질 및 바이러스 게놈 사이의 상호 작용은 RNA 대사 및 면역 반응과 관련된 조절 사건과의 강력한 연결을 보여줍니다

Article

Published on 2022-05-092022-09-11
Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] analyzed association BISPR Cell cellular cellular response characterized Cohort cohort of patient Combination complex component composed connection coronavirus Correlation analysis Defense defense mechanisms determine element event experimental evidence FMR1 FMR1-IT1 functional Host host cells human host cell human host cells human RNA identify immune response in silico infected cell Infection infectious agent Interaction interactions interferon interferon response intrinsic involved lncRNA long non-coding RNA mechanism metabolism MIR155HG modulate molecular ncRNAs Non-coding RNAs NRIR performed progression Protein rationale Regulation Regulatory regulatory network regulatory network. replicative reveal RNA RNA viruses RNA-binding protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load sequestering Specific Surveillance the interferon transcriptional transcriptomic triggered USP30 USP30-AS1 Viral viral genome viral infections viral RNA genome
[DOI] 10.7150/thno.73268 PMC 바로가기 [Article Type] Article

Characterization of a dynamic self-replicating mammalian expression vector based on the circular ssDNA genome of beak and feather disease virus

Article

Published on 2022-05-012023-07-09
Journal: The Journal of General Virology [Category] COVID19(2023년),

[키워드] beak and feather disease virus DNA expression vector gene-expression amplification replicative rolling-circle replication self-amplifying DNA self-replicating DNA Vaccine
[DOI] 10.1099/jgv.0.001746

SARS-CoV-2 viral load and replication in postmortem examinations

사후 검사에서 SARS-CoV-2 바이러스 부하 및 복제

Article

Published on 2022-05-012022-09-11
Journal: International Journal of Legal Medicine [Category] COVID19(2023년), SARS, 치료기술,

Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis

폐 섬유증에서 폐포 상피 줄기 세포 노화 및 노화 관련 분화 장애의 분자 기전

Review

Published on 2022-03-032022-09-11
Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] accelerated alveolar caused Cell cell senescence cellular senescence COVID-19 Degradation developmental differentiation disorder disrupt DNA damage DNA damage response dysfunction epithelial fibrosis followed by framework Idiopathic pulmonary fibrosis induce inhibiting inhibitor Intervention IPF low-grade inflammation mechanism molecular mechanism molecular mechanisms OIS oncogene pathway Premature Protein pulmonary pulmonary fibrosis replicative replicative senescence reported reverse transcriptase RNA SARS-CoV-2 viral infection senescence senescent cell senescent cells STEM stem cell suppression susceptibility telomerase telomerase and telomeres. telomeres TERC TERT TGF TGF-β TGF-β signalling TPP1 transcriptase Viral viral infection
[DOI] 10.3390/cells11050877 PMC 바로가기 [Article Type] Review

RNA SARS-CoV-2 Persistence in the Lung of Severe COVID-19 Patients: A Case Series of Autopsies

Microbiology

Published on 2022-01-312022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] addition Analysis Autopsy BK virus bronchopneumonia contribute contributing to Course COVID-19 COVID-19 patient death died disease Disease progression expected genomic RNA gRNA histopathological illness duration Immunocompromised immunohistochemistry immunomodulatory therapy immunosuprression include Infection lung lung cell lung lesions median mRNA onset of symptom onset of symptoms Patient pediatric persistence populations Protein Pulmonary infection replicative RNA RT-PCR SARS-CoV-2 secondary Sery severe COVID-19 sgRNA the disease viral persistance Viral protein viral replication virus
[DOI] 10.3389/fmicb.2022.824967 PMC 바로가기 [Article Type] Microbiology

Sequential infections with rhinovirus and influenza modulate the replicative capacity of SARS-CoV-2 in the upper respiratory tract

Coronaviruses

Published on 2022-01-272022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS,

[키워드] air–liquid interface airway epithelial cell Alpha variant blockade circulating circulation coronavirus 2 correlated COVID-19 had no IAV IBV immune response Infection Influenza Influenza virus inhibition Interaction interferon interferons investigated modulate modulated neutralizing antibody other respiratory virus pandemic patients prevalent prevented question Replication replicative reported respiratory respiratory virus respiratory viruses restored rhinovirus SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 replication suggested These data triggered type I upper respiratory tract variants of concern viral co-infections virus virus entry was impaired
[DOI] 10.1080/22221751.2021.2021806 PMC 바로가기 [Article Type] Coronaviruses