Heterologous boosting with third dose of coronavirus disease recombinant subunit vaccine increases neutralizing antibodies and T cell immunity against different severe acute respiratory syndrome coronavirus 2 variants코로나바이러스 질병 재조합 소단위 백신의 세 번째 용량으로 이종 부스팅은 다양한 중증 급성 호흡기 증후군 코로나바이러스 2 변이체에 대한 중화 항체 및 T 세포 면역을 증가시킵니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Anti-RBD IgG anti-S booster vaccination CD4+ T cell components composite pattern coronavirus coronavirus disease COVID-19 COVID-19 vaccinations COVID-19 vaccine dose effective epitope Epitopes evaluated Evidence help Heterologous heterologous boosting homologous Humoral immunity Immune escape Immunity immunization strategy immunological in some inactivated Inactivated vaccine increase magnitude NAb NAbs natural infection Neutralizing Neutralizing antibodies neutralizing antibody neutralizing capacity omicron pandemic prime-boost strategy produced RBD IgG respiratory subunit Subunit vaccine Subunit vaccine. T cell T cell response T cells titre vaccination Vaccination strategies Vaccination strategy Vaccine Vaccine-induced immunity variant variants of concern waned [DOI] 10.1080/22221751.2022.2048969 PMC 바로가기 [Article Type] Article
Influenza and other respiratory viruses in children: prevalence and clinical featuresArticle Published on 2022-12-012022-11-15 Journal: European Journal of Clinical Microbiology & Infect [Category] 신종인플루엔자, 진단, 치료기술, [키워드] age ARI Asthma clinical feature clinical manifestation collected cough COVID-19 pandemic Epidemic Epidemics Epidemiology female H1N1 ICU Infection Influenza influenza A influenza B other respiratory virus Patient positive Prevalence prevalent real-time RT-PCR respiratory respiratory infection respiratory virus respiratory virus respiratory viruses rhinoviruses RNA extraction specimens study period surveillance. tested virus was performed [DOI] 10.1007/s10096-022-04515-3 PMC 바로가기
Binding and neutralizing abilities of antibodies towards SARS-CoV-2 S2 domainSARS-CoV-2 S2 도메인에 대한 항체의 결합 및 중화 능력Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.7 B.1.351 B.1.617.2 B.1.621 binding binding activity carried conserved convalescent patient coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 determined by domain ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated Evidence Immune escape immune protection mAb mAbs MERS MERS-CoV Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus molecular monoclonal antibodies monoclonal antibody N Terminal N terminal domain NAbs Neutralization assay neutralization assay. Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody NTD P.1 Protein pseudo-virus RBD Receptor binding domain reported Research respiratory Result S protein S proteins S2 protein S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S2 SARS-CoV-2 WT Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly specific antibodies subunit target targets terminal Vaccine design variant variants wild-type [DOI] 10.1080/21645515.2022.2055373 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with SofosbuvirArticle Published on 2022-11-032022-11-15 Journal: PLoS Biology [Category] SARS, 치료제, [키워드] accompanied Affect alleviate alteration Antiviral antivirals Brain brain organoid brain organoids cell death cells cellular coronavirus 2 coronavirus disease cortical COVID-19 death determine drug excitatory food infect inhibit SARS-CoV-2 neurological manifestation Neurological symptoms neuronal neurons Newborn pandemic phenotype promote replicate Replication rescued respiratory respiratory illnesses SARS-CoV-2 sofosbuvir Treatment underlie variety WHO World Health Organization [DOI] 10.1371/journal.pbio.3001845 PMC 바로가기
Serum neurofilament light chain levels in Covid-19 patients without major neurological manifestationsArticle Published on 2022-11-012022-11-15 Journal: Journal of Neurology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] absence Admission baseline Biomarker Blood Brescia C-reactive protein change controls correlated COVID-19 CRP D-dimer disease severity evaluated Evidence excluded explained fibrinogen healthy controls Hospital stay Hospitalized hypoxic Increased longitudinal measure Neuroaxonal damage neurofilament Neurofilament light chain (NFL) neurological manifestation neurological manifestations neurotoxic PaO2/FiO2 ratio parameters Patient patients plasma promote reported respiratory respiratory impairment SARS-CoV-2 scale serum serum creatinine serum CRP Serum level serum sample serum. significantly Simoa systemic inflammation Variation were measured White blood cell with mild disease [DOI] 10.1007/s00415-022-11233-5 PMC 바로가기
Extended coagulation profile of children with Long Covid: a prospective studyArticle Published on 2022-11-012022-11-16 Journal: Scientific Reports [Category] SARS, 치료기술, [키워드] activated acute SARS-CoV-2 infection Adults age analyzed Antigen Biomarker case-control study change characterized children Coagulation cofactor Cohort control group controls D-dimer level D-dimers Diagnosis eight endothelial damage endotheliopathy enrolled explained Extended females fibrinogen Follow-up FVIII Infection initial International IQR ISARIC Italy Long majority microbiologically no significant difference normalized pediatric plasma profile profiles proportion Prospective Study Prothrombin time respiratory Sample SARS-COV-2 infection Symptom Symptoms the median the SARS-CoV-2 von Willebrand factor vWF [DOI] 10.1038/s41598-022-23168-y PMC 바로가기
COVID-19 vaccine effectiveness against hospitalization due to SARS-CoV-2: A test-negative design study based on Severe Acute Respiratory Infection (SARI) sentinel surveillance in SpainArticle Published on 2022-11-012022-11-16 Journal: Influenza and Other Respiratory Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Acute respiratory infection Admission age ARI Characteristics circulation COVID-19 COVID-19 hospitalization COVID-19 vaccine decrease Delta Effectiveness epidemiological estimate Evidence hospital Hospitalization hospitals Influenza mRNA vaccine mRNA vaccines no difference Older primary care respiratory SARI surveillance SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 Spain Spanish Surveillance surveillance network System test-negative design vaccination Vaccine vaccine effectiveness. [DOI] 10.1111/irv.13026 PMC 바로가기
Meta-analysis of the microbial biomarkers in the gut-lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infectionsArticle Published on 2022-11-012022-11-15 Journal: Letters in Applied Microbiology [Category] 바이오마커, [키워드] applied Biomarker Biomarkers Candida catastrophic cause Classifier Clostridium Clostridium difficile community-acquired pneumonia correlation COVID-19 COVID-19 infection data set Diversity Escherichia Faecalibacterium Gut gut-lung axis Health healthy Infection interplay lung Lungs metagenome microbial microbiota Mortality normalized offer organs pandemic processed profile prognostic biomarker progression random random forest classifier. respiratory Staphylococcus the disease the gut-lung axis trauma [DOI] 10.1111/lam.13798 PMC 바로가기
Pandemic driven innovation: A pilot evaluation of an alternative respiratory pathogen collection deviceArticle Published on 2022-11-012022-11-16 Journal: The American journal of emergency medicine [Category] SARS, 유전자 메커니즘, [키워드] absence All participant amplification communicable disease COVID-19 demonstrated determine diagnostic enrolled evaluated faster favor feedback fused gold standard identify inhibitor Innovation Interpretation invasive mechanism nasopharyngeal Nasopharyngeal swab nucleic acids participant Patient PCR PCR cycle PCR testing pilot study polymerase chain positive producing real-time reverse transcriptase receiving respiratory respiratory pathogen respiratory virus Result resulting RNase P RNAseP RT-qPCR Self-collection respiratory pathogen device. specimen study participant TaqPath tested threshold [DOI] 10.1016/j.ajem.2022.08.047 PMC 바로가기
Low Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission by Fomites: A Clinical Observational Study in Highly Infectious Coronavirus Disease 2019 PatientsArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] acute respiratory syndrome addressed baseline carrier Cell culture clinical coronavirus 2 coronavirus disease Coronavirus-2 coughing COVID-19 COVID-19 patient Culture Cycle threshold value evaluate fomite transmission Hospitalized Infectious virus initiated Intensive laboratory parameter occur oropharyngeal swab pandemic Patient polymerase chain positive Quantitative respiratory risk Saliva SARS-CoV-2 SARS-CoV-2 transmission Sequencing single-center stability surface stability. Swab Transmission unlikely Viral load viral ribonucleic acid virus virus transmission [DOI] 10.1093/infdis/jiac170 PMC 바로가기