Risk factors for COVID-19 case fatality rate in people with type 1 and type 2 diabetes mellitus: A nationwide retrospective cohort study of 235,248 patients in the Russian FederationObservational Study Published on 2022-08-092022-10-05 Journal: Frontiers in Endocrinology [Category] 임상, [키워드] 95% confidence interval absence age agonist anti-COVID-19 vaccination association atherosclerotic BMI body mass index cardiovascular disease Case fatality rate CFR Chronic kidney disease CKD clinical information Combination COVID-19 COVID-19 case database death diabete Diabetes Mellitus Dipeptidyl peptidase-4 disease Factor fatality Fatality rate Federation Glucose-lowering drug glucose-lowering therapy. group Increased inhibitor inhibitors insulin Laboratory male Observational cohort study Odds ratio Older age outcome Patient patients positive receptor Registered retrospective cohort study risk risk factor risk of death therapy type 2 diabete vaccination Vaccine was performed were used [DOI] 10.3389/fendo.2022.909874 PMC 바로가기 [Article Type] Observational Study
FURIN gene variants (rs6224/rs4702) as potential markers of death and cardiovascular traits in severe COVID-19심각한 COVID-19에서 사망 및 심혈관 특성의 잠재적 마커로서의 FURIN 유전자 변이체(rs6224/rs4702)Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] addition age allele association candidate Candidates cleaving COVID-19 COVID-19 patient COVID-19 patients death death case diabetes DNA variant DNA variants evaluated expression functional furin FURIN gene gene polymorphism Genotype genotyped Haplotype Homozygosis hypercholesterolemia hypercholesterolemia. hyperlipidaemia hypertension increased risk independent risk factor independent risk factors Infection infection cycle intensive care intensive care unit Logistic regression marker multiple logistic regression Odds ratio physiological protease regulate risk risk of death SARS-CoV-2 severe COVID-19 significantly significantly increased statistically susceptibility traits variant Viral protein Viral proteins virus [DOI] 10.1002/jmv.27748 PMC 바로가기 [Article Type] Article
Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patientsNF-κB 신호 전달 경로(NFKB1, NFKBIA, NFKBIZ)의 유전적 변이와 COVID-19 환자의 중대한 결과 위험Article Published on 2022-08-012022-09-11 Journal: Human immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Cohort component Control COVID-19 COVID-19 patient Critical D-dimer value Deceased explain form Gene polymorphisms genetic association Genetic variation Genotype healthy Homozygosis hyperinflammatory state ICU ICU admission implicated Inflammation insertion lower expression mice Mortality NF-κB NF-κB signaling NF-κB signaling pathway NFkB1 NFKBIA NFKBIZ NFKBIZ. outcome pathway Patient patients populations predisposition RATs Respiratory Support risk risk of death SARS-COV-2 infection Sepsis severe COVID-19 severe forms of COVID-19 significant effect Spanish patient Survivors the patient total blood transcript variant variants viral disease was increased [DOI] 10.1016/j.humimm.2022.06.002 PMC 바로가기 [Article Type] Article
Oral Janus kinase inhibitors for treating hospitalized patients with COVID-19: An updated systematic review and meta-analysis of randomized controlled trialsResearch article Published on 2022-08-012022-10-05 Journal: Journal of microbiology, immunology, and infection [Category] 신약개발, 임상, 치료제, [키워드] 28-day mortality 95% CI 95% confidence interval addition adverse event Analysis article Clinical efficacy control group Controlled COVID-19 database exhibited hospitalized patient investigated Janus kinase inhibitor Janus kinase inhibitors mechanical ventilation Meta-analysis Mortality objective oral patients with COVID-19 Randomized controlled trial RCTs receiving reduce Result risk risk of death searched significantly significantly lower systematic review the study group tolerable Treatment with COVID-19 [DOI] 10.1016/j.jmii.2022.08.005 [Article Type] Research article
COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults폴란드의 두 가지 유행성 전염병의 COVID-19 심각도 및 사망률과 입원한 젊은 성인의 SARS-CoV-2 감염의 나쁜 결과 예측Article Published on 2022-07-312022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] addition Adults adults hospitalized albumin Alpha Alpha variant analyzed blood cell blood cell counts C-reactive protein calcium Characteristics Clinical characteristics Comorbidities COVID-19 COVID-19 severity creatine creatine kinase creatinine D-dimer debatable decrease disease severity Factors filtration rate global public health glomerular filtration rate had no hematocrit hemoglobin Hospitalization identify increase in intensive care intensive care unit treatment interleukin interleukin-6 investigated Laboratory Lactate lactate dehydrogenase Leukocytosis Logistic regression lung involvement lymphocyte lymphopenia mechanical ventilation Mortality Myoglobin neutrophil Neutrophil-to-lymphocyte ratio neutrophilia no increase non-survivor obesity outcome pandemic Patient peptide performed Poland Poor predictor predictors procalcitonin red blood cell Retrospective study risk of death SARS-CoV-2 SARS-CoV-2 variants second wave severe COVID-19 severity survivor Treatment troponin I urea variant Vitamin Vitamin D3 Wave with COVID-19 young adults [DOI] 10.3390/v14081700 PMC 바로가기 [Article Type] Article
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysisCOVID-19로 병원에 입원한 환자의 바리시티닙(RECOVERY): 무작위, 통제, 공개 라벨, 플랫폼 시험 및 업데이트된 메타 분석Meta-Analysis Published on 2022-07-302022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 28-day mortality 95% CI age-adjusted rate ratio allocation Baricitinib benefit by mouth cause Corticosteroid Corticosteroids COVID-19 COVID-19 therapy death deaths died discharge eight enrolled evaluate Evidence hospital hospitalised Including Infection inhibitor Innovation intention-to-treat population ISRCTN Jak JAK inhibitor jak inhibitors janus Janus kinase Medical Research Council Meta-analysis mouth nine Non-COVID-19 once daily Open-label outcomes Patient Platform trial Primary outcome Proportional reduction randomisation randomised randomised controlled trial Randomised Evaluation Randomly randomly assigned patient rate ratio receive receiving recorded recovery RECOVERY trial reduce mortality reduced reduction in mortality Registered risk of death significantly Standard of care suggested thrombosis Tocilizumab Treatment Trial trials usual care usual care alone usual care group was done with COVID-19 [DOI] 10.1016/S0140-6736(22)01109-6 PMC 바로가기 [Article Type] Meta-Analysis
Characterization of demographic data, clinical signs, comorbidities, and outcomes according to the race in hospitalized individuals with COVID-19 in Brazil: An observational studyObservational Study Published on 2022-07-252022-10-05 Journal: Journal of Global Health [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI 95%CI addition age Analysis Asian black Brazil Characteristics characterization Clinical signs clinical symptom Clinical symptoms Comorbidities contribute contributed country COVID-19 pandemic death demographic data demonstrated described Diabetes Mellitus disease disorder Down syndrome Dyspnoea epidemiological evaluated FIVE hematologic Hospitalized immunosuppressive disorder Indigenous peoples individual individuals individuals with COVID-19 intensive care invasive male mechanical ventilation Ministry of Health Neurological disorder Non-invasive Nosocomial infection obesity outcome outcomes oxygen saturation pandemic performed positive result predict predictor renal risk of death RT-PCR SARS-CoV-2 SARS-COV-2 infection white [DOI] 10.7189/jogh.12.05027 PMC 바로가기 [Article Type] Observational Study
Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis중증이 아닌 COVID-19에 대한 항바이러스제 치료: 체계적인 검토 및 네트워크 메타 분석Meta-Analysis Published on 2022-07-252022-09-11 Journal: CMAJ : Canadian Medical Association journal = jour [Category] COVID19(2023년), meta-analysis, SARS, 변종, 치료제, [키워드] 95% CI 95% confidence interval Admission Adult patients antiviral drug antiviral drugs antiviral treatments approach assessment certainty certainty of evidence conducted COVID-19 database death development drug effective Effectiveness Evidence Hospital admission Hospital admissions moderate molnupiravir MOST Network meta-analysis Nirmatrelvir no effect omicron Omicron variant Patient patients patients with COVID-19 performed Placebo randomized trial randomized trials reduce reduced risk reducing Remdesivir risk Risk of bias risk of death Ritonavir searched standard care systematic review tested Treatment Trial trials variants [DOI] 10.1503/cmaj.220471 PMC 바로가기 [Article Type] Meta-Analysis
Updated Living Systematic Review and Meta-analysis of Controlled Trials of Mesenchymal Stromal Cells to Treat COVID-19: A Framework for Accelerated Synthesis of Trial Evidence for Rapid Approval-FASTER ApprovalCOVID-19를 치료하기 위한 중간엽 간질 세포의 통제된 시험에 대한 업데이트된 살아있는 체계적인 검토 및 메타 분석: 신속한 승인-빠른 승인을 위한 시험 증거의 가속화된 합성을 위한 프레임워크Meta-Analysis Published on 2022-07-202022-09-11 Journal: Stem cells translational medicine [Category] 임상, [키워드] accelerate accelerated acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 appear approval ARDS Clinical studies clinical study conducted Consistency Control Controlled controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria Critical death Endpoint evaluate Evidence Exosomes Extracellular Extracellular vesicles facilitate framework heterogeneity Hospital stay identify IMPROVE ISCT Master protocol mean difference Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells Meta-analysis Microvesicles moderate Mortality MSC MSC-EVs exosomes MSCs non-randomized study outcome Oxygenation Patient Pneumonia PROSPERO protocol random-effect random-effects Random-effects meta-analysis Randomized controlled trial Rapid reduce reduce mortality Relative risk reported respiratory distress Respiratory distress syndrome review risk of bia risk of death RoB SARS-CoV-2 Sepsis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Society stromal cell stromal cells synthesis systematic review treat Treatment [DOI] 10.1093/stcltm/szac038 PMC 바로가기 [Article Type] Meta-Analysis
Interleukin-6 inhibitors reduce mortality in coronavirus disease-2019: An individual patient data meta-analysis from randomized controlled trialsInterleukin-6 억제제는 코로나바이러스 질병-2019의 사망률을 감소시킵니다: 무작위 대조 시험의 개별 환자 데이터 메타 분석Meta-Analysis Published on 2022-07-012022-09-11 Journal: European journal of internal medicine [Category] 임상, [키워드] 95%CI age Analysis confidence confidence interval coronavirus COVID-19 COVID-19 patients data extraction database death discharge discharge rate Efficacy eligible hazard hazard ratio hospitalized COVID-19 patient hospitalized COVID-19 patients IL-6 IL-6 inhibitor IL-6 inhibitors individual inhibitor inhibitors Inteleukin-6 intubation Kaplan-Meier curve meta-analyses Meta-analysis outcome Patient patient data patients Randomized control trials Randomized controlled trial randomized trial randomized trials Ratio RCTs reduce reduce mortality risk risk of death significantly SOC. Standard of care synthesis systematic review the mean the MEDLINE Trial two group two groups was performed [DOI] 10.1016/j.ejim.2022.04.004 PMC 바로가기 [Article Type] Meta-Analysis