Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates Research Published on 2022-06-022022-10-05 Journal: Nature biotechnology [Category] Coronavirus, 진단, [키워드] administration Alzheimer’s disease amyloid precursor protein approved Cell cell types Central nervous system CNS conjugate Efficacy evaluated hepatocyte intranasal intravitreal knockdown liver lung non-human primate organs physiological Region resulting RNA RNA interference rodent Safe siRNA siRNAs specificity sustained target gene therapeutic Therapeutics tissue [DOI] 10.1038/s41587-022-01334-x [Article Type] Research
Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition virus VSV-GFP [DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article
Improving siRNA design targeting nucleoprotein gene as antiviral against the Indonesian H5N1 virusArticle Published on 2022-03-012023-06-22 Journal: Journal of veterinary science [Category] 조류인플루엔자, [키워드] Antiviral agents H5N1 subtype Indonesia influenza in birds RNA interference [DOI] 10.4142/jvs.21174 PMC 바로가기
Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 InfectionResearch Article Published on 2022-02-152022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] N-glycosylation Ablation acute respiratory syndrome Antiviral agents B.1.1.7 B.1.351 B.1.617.2 Beta binding block Cell conditions coronavirus Coronavirus-2 COVID-19 Critical Delta FDA-approved drugs Gamma glycan glycosylate glycosylation Host host cell host immunity host receptor immunotherapies Infection inhibition inhibitors Invasion investigated modulate N -glycosylation P.1 pathway predicted produced Protein reduced RNA interference SARS-CoV-2 SARS-CoV-2 N Spike proteins Spread Treatment Vaccine variant viral infection virion [DOI] 10.1128/mbio.03718-21 PMC 바로가기 [Article Type] Research Article
In Silico Prediction and Selection of Target Sequences in the SARS-CoV-2 RNA Genome for an Antiviral AttackArticle Published on 2022-02-142022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), Fulltext, SARS, [키워드] 229E alternative methods analyzed Antiviral antiviral drugs Antiviral strategies antiviral strategy approaches attack conserved contribute Coronaviruses COVID-19 CRISPR-Ca CRISPR-Cas13d effective HKU1 human coronavirus humans MERS-CoV Molecular biology NL63 nucleotide OC43 omicron outbreak Pandemics performed prediction protective vaccine provide related viruses replicate RNA RNA interference Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 isolates SARS-CoV-2 pandemic screened Selection sequence target the SARS-CoV-2 the SARS-CoV-2 genome unique variant [DOI] 10.3390/v14020385 PMC 바로가기 [Article Type] Article
The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion ReleaseResearch Article Published on 2022-02-012022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] acute respiratory syndrome autophagy cellular membranes complex coronavirus dependent on E3 ligase ENhance enzyme Golgi apparatus Interaction Ligase maturation membrane protein Modification molecular mechanism performed regulate Release residue RNA interference RNF5 SARS-CoV-2 ubiquitin ubiquitination viral envelope protein viral particle virion virus virus-like particles [DOI] 10.1128/mbio.03168-21 PMC 바로가기 [Article Type] Research Article
Knockdown of FLT4, Nup98, and Nup205 Cellular Genes Effectively Suppresses the Reproduction of Influenza Virus Strain A/WSN/1933 (H1N1) In vitroArticle Published on 2022-01-012023-06-23 Journal: Infectious disorders drug targets [Category] 신종인플루엔자, [키워드] Genes influenza A virus Messenger RNA RNA interference small interfering RNAs transfection [DOI] 10.2174/1871526522666220325121403
SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes407 Published on 2021-12-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Argonaute basic BATF2 cell lines cellular cellular RNA component conserved contribute coronavirus coronavirus disease COVID-19 described detect expresse Factor Health Host host gene host miRNA identify independent individuals interferon signaling investigated micoRNA microRNA miRNA moderate Nasopharyngeal swab noncoding RNA ORF7a pathway Population Protein regulate repress RNA RNA interference SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis sequence Significance target therapeutic intervention transcripts Zipper [DOI] 10.1073/pnas.2116668118 PMC 바로가기 [Article Type] 407
Targeting Inflammasome Activation in COVID-19: Delivery of RNA Interference-Based Therapeutic MoleculesReview Published on 2021-12-032022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] absence Activation approach clinical outcomes clinical trial complications Consequences COVID-19 COVID-19 patient COVID-19 patients Critical delivery dependent on Drug efficacy dysregulation effective Efficacy immune dysregulation Inflammasome inflammasome activation mechanisms microRNA modulating Molecular targets molecule morbidity NLRP3 NLRP3 inflammasome non-coding RNA Non-coding RNAs Numerous pathogenesis of COVID-19 potential therapeutic target pro-inflammatory cytokine pro-inflammatory mediator reduce Research RNA RNA interference RNAs significantly targeting the cytokine storm therapeutic agent Therapeutic molecule Treatment Treatment strategies Vaccines variants of SARS-CoV-2 vector with COVID-19 worsened [DOI] 10.3390/biomedicines9121823 PMC 바로가기 [Article Type] Review