Short-hairpin RNAs delivered by recombinant adeno-associated virus inhibited the replication of influenza A viruses in vitroArticle Published on 2021-12-012023-06-24 Journal: Virology [Category] 신종인플루엔자, [키워드] AAV influenza A virus Replication RNAi Short-hairpin RNAs. [DOI] 10.1016/j.virol.2021.10.002 PMC 바로가기
Specific delivering of RNAi using Spike’s aptamer‐functionalized lipid nanoparticles for targeting SARS‐CoV‐2: A strong anti‐Covid drug in a clinical case studyCase Report Published on 2021-11-242023-06-15 Journal: Chemical biology & drug design [Category] COVID19(2023년), MERS, SARS, [키워드] Antiviral aptamer inhalation Lipid nanoparticles RNAi SARS‐CoV‐2 [DOI] 10.1111/cbdd.13978 PMC 바로가기 [Article Type] Case Report
Dysregulation of RNA interference components in COVID-19 patientsCOVID-19 환자에서 RNA 간섭 성분의 조절 조절Research Note Published on 2021-10-292022-09-10 Journal: BMC Research Notes [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Ago2 Antiviral China component coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19patient COVID-19patients Defense defense mechanisms demonstrated DGCR8 Dicer Drosha dysregulated expression expression level Health healthy individuals healthy subjects inhibiting mechanism mRNA mRNAs Novel coronavirus objective Post-transcriptional gene silencing respiratory Respiratory illness Result RNA interference RNAi SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severe respiratory illness statistically suggested supplementary material Viral Viral proteins virus virus replication Wuhan [DOI] 10.1186/s13104-021-05816-0 PMC 바로가기 [Article Type] Research Note
SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatmentRNAi에 의한 SARS-CoV-2 표적화 및 숙주 보체 억제: COVID-19 치료를 위한 두 갈래의 속임수Review Published on 2021-10-132022-09-10 Journal: Immunity, Inflammation and Disease [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach C3a clinical manifestation clinical manifestations complement Complement inhibitor component conjunction coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patients curtail cytokine Cytokine storm degrade detrimental Disease progression disease progression and severity downstream effective Evidence exacerbate gene regulation processes globe Host immune responses infections information inhibitor knowledge lack less Local mitigate molecules ORF Perspective preventive measure preventive measures progression Proinflammatory cytokine protective immunity Replication required respiratory Result RNA interference RNAi robust SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Spread suppress symptomatic and asymptomatic systemic immune response systemic immune responses the cytokine storm transcript transmissible variant Treatment vaccinate Vaccine variants Viral viral spread viral/retroviral virus [DOI] 10.1002/iid3.549 PMC 바로가기 [Article Type] Review
Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader Sequence리더 서열을 표적으로하는 작은 간섭 RNA에 의한 SARS-COV-2 복제의 억제Article Published on 2021-10-082022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 신약개발, 진단, 치료제, [키워드] 5′-UTR 5′-untranslated region 5′-UTR acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed assays conserved coronavirus COVID-19 Cytopathic effect death delta variant eight family member genomic highly active homology inhibition initial leader sequence magnitude means prevented reduced replication Replication reporter respiratory retained RNA RNA interference RNAi RNAi therapy SARS-CoV virus SARS-CoV viruses SARS-CoV-1 SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 siRNA siRNAs subgenomic RNAs suppress target targeting the SARS-CoV-2 Treatment Vaccine development variant Viral viral infection viral infections viral replication virus virus replication viruses [DOI] 10.3390/v13102030 PMC 바로가기 [Article Type] Article
Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapyArticle Published on 2021-09-282023-07-01 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, [키워드] antiviral therapy bat CRISPR RNAi [DOI] 10.1073/pnas.2104759118 PMC 바로가기
Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch toleranceArticle Published on 2021-07-132022-10-04 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] antiviral drug antiviral therapeutics approach B.1.1.7 cellular circumvent CRISPR CRISPR-Cas systems D614G degrade demonstrated described dominant variant effector Efficiency genomic highlight host immunity impair Interaction mammalian cell mammalian cells molecular Mutagenesis mutant mutated pathogenic viruses Prevent Region replication-competent SARS-CoV-2 Resilience RNA RNA transcript RNAi RNAi therapy SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 replication SARS-CoV-2 strain SARSCoV-2 single-nucleotide specificity spike subgenomic RNAs suppress suppresse Synthetic biology the Spike Tolerance transcript variant variants of concern viral escape viral replication [DOI] 10.1038/s41467-021-24577-9 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19코로나19에 대한 SARS-CoV-2 표적 siRNA-나노입자 치료Article Published on 2021-07-072022-09-11 Journal: Molecular therapy : the journal of the American So [Category] SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered approach caused Combination conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease cure demonstrated disease effective encapsulation followed by greater humans in vivo Infection inhibit injection Lipid nanoparticle LNP lung Lungs mice Multiple organ Region RNA RNAi robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus screened severe acute respiratory syndrome Coronavirus siRNA siRNAs Small interfering RNA stealth survival the SARS-CoV-2 virus therapeutic Therapeutic approach therapy therapy for COVID-19 Therapy. treated treating COVID-19 Vaccine Vaccines virus [DOI] 10.1016/j.ymthe.2021.05.004 PMC 바로가기 [Article Type] Article
HBsAg, Subviral Particles, and Their Clearance in Establishing a Functional Cure of Chronic Hepatitis B Virus InfectionReview Published on 2021-06-112023-06-13 Journal: ACS Infectious Diseases [Category] B형 간염, [키워드] functional cure HBsAg immune inhibition integrated HBV DNA Nucleic acid polymers Quasispecies RNAi subviral particle. [DOI] 10.1021/acsinfecdis.0c00638 PMC 바로가기 [Article Type] Review
Roles of host small RNAs in the evolution and host tropism of coronavirusesArticle Published on 2021-03-162023-07-01 Journal: Briefings in Bioinformatics [Category] SARS, [키워드] adaptive mutation coronavirus host tropisms miRNA RNAi [DOI] 10.1093/bib/bbab027 PMC 바로가기