Identification of conserved regions from 230,163 SARS-CoV-2 genomes and their use in diagnostic PCR primer design230,163 SARS-CoV-2 게놈에서 보존 영역 식별 및 진단 PCR 프라이머 디자인에서의 사용Article Published on 2022-08-012022-09-11 Journal: Genes & genomics [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] addition Alpha amplification approach Beta bioinformatics can be used candidate Candidates characteristic conserved Coverage dataset Delta Diagnosis diagnostic Epsilon Eta evaluated exhibited False negative full-length Gamma genome sequence genomes genomic sequence GISAID GISAID EpiCoV database identification identify in silico Intensive Iota Multiple Multiple sequence alignment multiple sequence alignments NCBI nine NSP2 orf3a gene Outbreaks pandemic PCR PCR primer primer primer set primer sets Primers qPCR RdRP Region removal retrieved RNA sample RNA samples RT-qPCR S gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant sequence Sequence alignment target viral genome viral sequences was reduced Zeta [DOI] 10.1007/s13258-022-01264-7 PMC 바로가기 [Article Type] Article
The short-term effect of different chlorhexidine forms versus povidone iodine mouth rinse in minimizing the oral SARS-CoV-2 viral load: An open label randomized controlled clinical trial studyRandomized Controlled Trial Published on 2022-07-292022-10-05 Journal: Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] ARMS assigned baseline collected conducted control group Controlled clinical trial COVID-19 E gene Efficiency evaluated form four group group Intervention less male open label P-value participant Patient povidone randomization Randomized real time PCR recruited reduction S gene Saliva salivary SARS-CoV-2 SARS-CoV-2 viral second significant decrease statistically significant difference subject the SARS-CoV-2 threshold Viral load was collected was recorded [DOI] 10.1097/MD.0000000000028925 PMC 바로가기 [Article Type] Randomized Controlled Trial
Smartphone-Based SARS-CoV-2 and Variants Detection System using Colorimetric DNAzyme Reaction Triggered by Loop-Mediated Isothermal Amplification (LAMP) with Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)Article Published on 2022-07-262022-11-16 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accuracy acute respiratory syndrome affected blind Cas9 clinical samples clinical sensitivity coronavirus COVID-19 COVID-19 patient CRISPR CRISPR-Cas9 D614G detection diagnosed Diagnosis diagnostic disease Diseases eliminated expected False-positive isothermal amplification machine learning Mutation Omicron variant Palindromic palindromic repeat patients Protein raised reaction Repeat S gene SARS-CoV-2 SARS-CoV-2 delta sensitivity Smartphone specificity System T478K the SARS-CoV-2 triggered variant variants [DOI] 10.1021/acsnano.2c04840 PMC 바로가기
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera쥐 감염 및 인간 면역 혈청 탈출에 중요한 SARS-CoV-2 스파이크 돌연변이의 특성화Article Published on 2022-07-072022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] (alpha ACE-2 Alpha angiotensin angiotensin converting enzyme B.1.1.529 B.1.1.7 B.1.351 Beta cause characterization convalescent disease Efficiency enzyme Gamma genetic background H655Y immune infect Infection insertion Lineage lineages lung mice Mild Mild disease morbidity murine Mutation N genes N501Y neutralization not affect obese omicron Omicron variants P.1 post vaccination receptor Receptor binding domain S gene S protein SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 Spike mutation SARS-CoV-2 variant SARS-CoV-2 variants sera Transmissibility USA-WA1/2020 variants virus viruses VOCs wild type [DOI] 10.1038/s41467-022-30763-0 PMC 바로가기 [Article Type] Article
The rapid replacement of the SARS-CoV-2 Delta variant by Omicron (B.1.1.529) in England영국에서 SARS-CoV-2 Delta 변종을 Omicron(B.1.1.529)으로 신속하게 대체Article Published on 2022-07-062022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected B.1.1.529 caused changes changes in Christma Christmas competition competitive advantage coronavirus Delta delta variant doubling elicited England Epidemics faster Frequency growth growth rate Hierarchical International Logistic long term mechanism omicron PCR tests peaked public health messaging Region replaced replacement replacing S gene S gene target failure SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus slowdown Spread Stage synchrony the SARS-CoV-2 Vaccine vaccine doses variant [DOI] 10.1126/scitranslmed.abo5395 PMC 바로가기 [Article Type] Article
Comparative analysis of SARS-CoV-2 quasispecies in the upper and lower respiratory tract shows an ongoing evolution in the spike cleavage site상부 및 하부 호흡기에서 SARS-CoV-2 유사종의 비교 분석은 스파이크 절단 부위에서 진행 중인 진화를 보여줍니다Article Published on 2022-07-022022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Cell cleavage site Comparative analysis coronavirus deep deep sequencing Deleterious mutations evidenced Evolution explained genomic humans incidence INDEL indels intensive care intensive care unit locus Lower respiratory tract LRT Macrophage Minority variants Mutation Next-generation sequencing Non-synonymous mutation Patient phagocytosis Quasispecies quasispecy Result S gene SARS-CoV-2 selective severe acute respiratory syndrome Coronavirus specimens spike Spike protein spillover the Spike upper and lower respiratory tract upper respiratory tract URT variant variants viral quasispecy virus was performed [DOI] 10.1016/j.virusres.2022.198786 PMC 바로가기 [Article Type] Article
Rampant C-to-U deamination accounts for the intrinsically high mutation rate in SARS-CoV-2 spike geneArticle Published on 2022-07-012023-07-09 Journal: RNA (New York, N.Y.) [Category] COVID19(2023년), [키워드] C-to-U deamination mutation rate S gene SARS-CoV-2 single-stranded RNA. [DOI] 10.1261/rna.079160.122
Detection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City뉴욕시에서 알파 및 엡실론 변이체로 중복 감염 중 SARS-CoV-2 숙주 내 재조합 검출Article Published on 2022-06-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] allele Alpha Alpha variant B.1.1.7 B.1.429 classic coding regions Coronavirus replication detection Diversity Epsilon feasible full genome sequencing functions generate genetic diversity Genome genome sequence genomes Haplotype Host identify independent individual infect New York City nucleocapsid Occurrence ORF pathogen Pathogens Recombination reveal S gene SARS-CoV-2 superinfection Support variant virus [DOI] 10.1038/s41467-022-31247-x PMC 바로가기 [Article Type] Article
Dynamics of SARS-CoV-2 Alpha (B.1.1.7) variant spread: The wastewater surveillance approachSARS-CoV-2 Alpha(B.1.1.7) 변종 확산의 역학: 폐수 감시 접근 방식Article Published on 2022-05-152022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Alpha VOC Analysis analyzed Antibody binding approach average B.1.1.7 circulating circulation Combination Complete dominant Dynamics Epidemiology Europe explained herd immunity identify Immunity initial Mutation N gene NGS offer other variant other variants Outcompetition rate parameter plant qPCR real-time qPCR RT-qPCR S gene S glycoprotein S477N SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants spike glycoprotein Spread statistically Surveillance the SARS-CoV-2 Transmissibility Treatment United Kingdom variant variant of concern VoC was determined wastewater Wastewater-based epidemiology [DOI] 10.1016/j.envres.2022.112720 PMC 바로가기 [Article Type] Article
Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variantsSARS-CoV-2 오미크론 및 델타 변이체에 대한 mRNA-1273의 효과Article Published on 2022-05-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus B.1.1.529 case-control study conducted coronavirus declined Delta delta variant determined by Effectiveness evaluate Hospitalization Immune escape Immunocompromised immunocompromised individuals Infection mRNA mRNA-1273 mRNA-1273 vaccine omicron S gene SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 study population variant variants [DOI] 10.1038/s41591-022-01753-y PMC 바로가기 [Article Type] Article