A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike공개 항체 클래스는 SARS-CoV-2 스파이크의 개방형 구조에 노출된 S2 에피토프를 인식합니다.Article Published on 2022-08-042022-09-12 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] antibody approved average B cell benefit Complete conformation Critical elicited epitope flow cytometry fraction help individual memory memory B cell phenotype pre-fusion receptor recognize S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccines Sequencing single-cell target the SARS-CoV-2 vaccination Vaccine [DOI] 10.1038/s41467-022-32232-0 PMC 바로가기 [Article Type] Article
Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infectionOmicron BA.1 돌발성 감염 후 기존 교차 반응성 B 세포 기억 회상Article Published on 2022-07-292022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody Response B cell B cell memory B cell response Breakthrough infection characterized conserved coronavirus cross-reactive Donor donors facilitate feature Heterologous immune response immune responses immunodominance Infection memory B cells Messenger RNA Neutralizing antibodies neutralizing antibody omicron Preexisting immunity proportion RBD Receptor binding domain Recognition respiratory S2 subunit SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shift understanding Vaccines VOCs [DOI] 10.1126/sciimmunol.abq3511 PMC 바로가기 [Article Type] Article
Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome Research Published on 2022-07-192022-10-05 Journal: Nature Communications [Category] 바이오마커, 임상, [키워드] antibody Antibody titer baseline binding booster vaccination clinical trial conducted coronavirus epitope Epitopes evaluate exploratory expressing homologous humoral responses identify IgG immunization immunogenic Increased magnitude MERS-CoV Middle East neutralization Neutralizing pandemic participant Phase 1 RBD respiratory syndrome coronavirus responses S2 subunit Safe spike glycoprotein Support syndrome the receptor-binding domain trial participant trials two-dose regimen vaccination vaccine candidate [DOI] 10.1038/s41467-022-31557-0 [Article Type] Research
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses치명적인 COVID-19 결과는 풍토성 코로나바이러스와 공유되는 에피토프를 표적으로 하는 항체 반응과 관련이 있습니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Adaptive immunity antibody Antibody Response Antibody responses antigenic beta-coronavirus characteristic conservation coronavirus coronavirus disease Coronavirus disease 2019 correlated strongly correlation COVID-19 cross-reactive disease Disease progression domain Endemic epitope Epitopes fatal COVID-19 full-length spike protein highest ICU immune response immune responses immunology Imprinting individual Infection Infectious disease intensive care intensive care unit less magnitude not significantly different nucleocapsid outcome outcomes proportion Protective Region respiratory Respiratory Coronavirus response S2 subunit SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein severe acute respiratory coronavirus Spike protein Spike proteins subunits the antibody response the SARS-CoV-2 variable regions [DOI] 10.1172/jci.insight.156372 PMC 바로가기 [Article Type] Article
Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2Omicron BA.1 및 BA.2에 효과적인 강력한 인간 SARS-CoV-2 중화 IgA 및 IgG 항체Article Published on 2022-07-042022-09-11 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] animal models antibody Antibody Response Antibody responses Antiviral B-cell boost breadth candidate Cell cellular contribute convalescent COVID-19 demonstrated Diversity effective effector elicited functions Humoral immunity IgA IgA antibodies IgA antibody IgG antibodies IgG antibody immune protection memory B memory B cell memory B-cell monoclonal antibody mucosal tissue mucosal tissues Neutralizing omicron potent prevented provided Receptor-binding domain S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant serological severe COVID-19 Spike protein the receptor-binding domain the SARS-CoV-2 therapeutic efficacy Treatment Wuhan [DOI] 10.1084/jem.20220638 PMC 바로가기 [Article Type] Article
Self-derived peptides from the SARS-CoV-2 spike glycoprotein disrupting shaping and stability of the homotrimer unitSARS-CoV-2 스파이크 당단백질의 자가유래 펩타이드가 동종삼량체 단위의 형태와 안정성을 방해Article Published on 2022-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] approach binding binding affinity blocker blockers conformation COVID dataset destabilized develop disrupting domain exhibited functional higher affinity homotrimer host cell host cell receptor instability linear Linear motif molecular molecular dynamics monomer motif mutated Mutation opposite peptide peptides Protein protein structure RBD Region regions responsible resulting S protein S1 and S2 S1 and S2 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 S Self-derived peptides shown spike spike glycoprotein stability Structural folding structure-based design subunit Support the S protein the SARS-CoV-2 Vaccine Vaccine design variant wild type β-coronavirus [DOI] 10.1016/j.biopha.2022.113190 PMC 바로가기 [Article Type] Article
Development of a cost-effective ovine antibody-based therapy against SARS-CoV-2 infection and contribution of antibodies specific to the spike subunit proteinsSARS-CoV-2 감염에 대한 비용 효율적인 양 항체 기반 요법의 개발 및 스파이크 소단위 단백질에 대한 항체의 기여Article Published on 2022-07-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] affinity antibodies antibody Antibody titre antibody-based therapy Antigen approval approved B.1.1.529 complement complement fixation convalescent plasma COVID-19 demonstrated development evaluated fixation generate highly active Immunoglobulin in vitro Neutralising activity omicron performed phagocytosis plasma polyclonal antibodies polyclonal antibody protective immunity Protein provide raised Regulatory S1 and S2 S2 subunit SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection sheep Spike protein subunit therapy therapy for COVID-19 variant virus was collected widespread [DOI] 10.1016/j.antiviral.2022.105332 PMC 바로가기 [Article Type] Article
Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern우려되는 SARS-CoV-2 변이체에 대한 융합 억제 리포펩티드의 효능Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] affected antibodies antiviral efficacy Beta causative agent concern conformational conserved convalescent COVID-19 cross-protective described dimeric doses effective Efficacy elicited evade expected ferret ferrets FIVE Frequency fusion inhibitor Immunity in vitro in vivo Infection Intervention less lipopeptide mechanism of action monoclonal antibody monoclonal antibody therapy monomeric neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody peptide peptides postvaccination postvaccine sera potency Protein Receptor binding Receptor-binding domain reported resulting S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2 variant selective selective pressure selective pressures sera Seven shown spike Spike protein Spread strain the receptor-binding domain therapeutic therapy vaccination Vaccine variant Viral viral entry viral evolution viral infection virus virus neutralization assays VoC VOCs Waves [DOI] 10.1128/mbio.01249-22 PMC 바로가기 [Article Type] Article
Seasonal coronaviruses and SARS-CoV-2: effects of preexisting immunity during the COVID-19 pandemic계절성 코로나바이러스 및 SARS-CoV-2: COVID-19 전염병 동안 기존 면역의 영향Article Published on 2022-06-152022-09-11 Journal: Journal of Zhejiang University. Science. B [Category] COVID19(2023년), SARS, 치료법, [키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADE Affect antibody Antibody-dependent enhancement antigenic B cell B cells Consequences coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 pandemic death Disease progression drug Effect Effects Epidemic Evidence evidence of followed by help HKU1 humans Immune cell immune cells immune response individuals likelihood memory T nucleocapsid OAS OC43 outcomes pandemic positive Post-infection Preexisting immunity Prevalence PROTECT Protein reduce Region Research rising S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection seasonal seasonal coronaviruses severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severity of COVID-19 suggested T cell T cells target Treatment vaccination rate vaccination rates Vaccine Vaccine development [DOI] 10.1631/jzus.B2200049 PMC 바로가기 [Article Type] Article
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 Research Published on 2022-05-092022-10-05 Journal: Nature metabolism [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accompanied antiviral activity bind Blood cause cellular entry Comorbidity contribute COVID-19 COVID-19 pathogenesis diabete Diabetes Mellitus Diabetic diabetic patient disease severity effective healthy individual identify inhibit mechanism membrane fusion metabolite mice Mortality much higher patients patients with diabete patients with diabetes reduce respiratory tissue S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication serum severe COVID-19 severity significantly lower Spike protein susceptibility the SARS-CoV-2 undergo viral infection Viral load wild-type [DOI] 10.1038/s42255-022-00567-z [Article Type] Research