SARS-CoV-2 N – Page 2 – Communicable Diseases Research

Nucleocapsid protein of SARS-CoV-2 is a potential target for developing new generation of vaccine

SARS-CoV-2의 뉴클레오캡시드 단백질은 차세대 백신 개발을 위한 잠재적인 표적입니다

Article

Published on 2022-06-012022-09-11
Journal: Journal of Clinical Laboratory Analysis
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

SARS-CoV-2 and Mitochondrial Proteins in Neural-Derived Exosomes of COVID-19

코로나19 신경 유래 엑소좀의 SARS-CoV-2 및 미토콘드리아 단백질

Article

Published on 2022-06-012022-09-11
Journal: Annals of neurology
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료법,

[키워드] 12S rRNA acute COVID-19 anion ANN Astrocyte Biomarker Biomarkers calcium calcium channel CD81 Cell Central nervous system Complex I complex III controls COVID-19 Exosome extracellular vesicle Extracellular vesicles Frame healthy controls Human Humanin LETM1 leucine long-COVID manifestation marker MCU mechanism Mitochondria mitochondrial N-methyl-D-aspartate N-methyl-D-aspartate receptor Neuropsychiatric nucleocapsid PASC plasma Protein quantified resolved respiratory chain S1 protein SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 S1 significantly sodium subunit therapeutic therapeutic trials transmembrane trials VDAC1 was used
[DOI] 10.1002/ana.26350 PMC 바로가기 [Article Type] Article

Detection of SARS-CoV-2 Nucleocapsid, Spike, and Neutralizing Antibodies in Vaccinated Japanese

백신을 접종한 일본인에서 SARS-CoV-2 뉴클레오캡시드, 스파이크 및 중화 항체 검출

Article

Published on 2022-05-052022-09-11
Journal: Viruses
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody titers coronavirus correlated detection detection system Efficacy Efficiency Elecsy Elecsys evaluate evaluated Fujirebio healthy subject healthy subjects IgG investigated Japanese Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers nucleocapsid patients with COVID-19 respiratory Roche SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 N sensitivity sera serological test severe acute respiratory syndrome Coronavirus specificity spike vaccination vaccination. were assessed
[DOI] 10.3390/v14050965 PMC 바로가기 [Article Type] Article

Quantitative serology for SARS-CoV-2 using self-collected saliva and finger-stick blood

자가 채취한 타액과 손가락 채혈을 이용한 SARS-CoV-2의 정량적 혈청학

Article

Published on 2022-04-212022-09-12
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 진단,

A Simple and Universal Nucleic Acid Assay Platform Based on Personal Glucose Meter Using SARS-CoV-2 N Gene as the Model

SARS-CoV-2 N 유전자를 모델로 사용하는 개인 혈당 측정기를 기반으로 하는 간단하고 보편적인 핵산 분석 플랫폼

Article

Published on 2022-04-152022-09-11
Journal: Biosensors
[Category] COVID19(2023년), SARS, 치료기술, 치료제,

Plasma Biomarkers of Neuropathogenesis in Hospitalized Patients With COVID-19 and Those With Postacute Sequelae of SARS-CoV-2 Infection

입원한 COVID-19 환자 및 SARS-CoV-2 감염의 급성 후유증이 있는 환자의 신경병증 발생에 대한 혈장 바이오마커

Article

Published on 2022-03-072022-09-11
Journal: Neurology® neuroimmunology & neuroinflammation
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, 치료법,

[키워드] Acidic Activation addition Antigen antigenemia antigenic antigenic stimulation Anxiety assessments association biochemical evidence Blood calculated CNS cognitive concentrations coronavirus correlated COVID-19 COVID-19 disease detectable detection develop diagnosis of COVID-19 dysfunction Encephalopathy enrolled Evidence evidence of exhibited groups healthy control Hospitalization Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Infection initial Injury latent infection life light chain manifestation Measures Mild neurologic neuronal Neuropathogenesis Neuropsychiatric nucleocapsid antigen occur Older PASC pathogenic mechanism pathogenic mechanisms Patient patients patients hospitalized plasma plasma biomarker PNP presenting Protein recruited required respiratory Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 N Simoa Study participants subjects Symptom Symptoms symptoms onset These data were measured with COVID-19
[DOI] 10.1212/NXI.0000000000001151 PMC 바로가기 [Article Type] Article

Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 Infection

Research Article

Published on 2022-02-152022-10-29
Journal: mBio
[Category] COVID-19, MERS,

High level SARS-CoV-2 nucleocapsid refolding using mild condition for inclusion bodies solubilization: Application of high pressure at pH 9.0

고급 SARS-COV-2 NucleoCapsid 포함 물체 용량을위한 온화한 상태를 사용한 폴딩 : pH 9.0에서 고압의 적용

Research Article

Published on 2022-02-032022-09-10
Journal: PLoS ONE
[Category] COVID19(2023년), MERS, SARS, 진단, 치료법,

[키워드] aggregate alkaline antibody Antibody binding Antigen application association Bacterial best binding condition conserved Coronaviruses Culture culture media described Diagnosis dialysis Disulfide E . coli effective electrostatic repulsion ELISA expressed for inclusion fragment of Host hydrophobic Inclusion inclusion bodies ionic interaction kDa knowledge media Mild motif non-specific Patient presenting promote promoted Protein purification purity SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid sera solubilization tertiary structure Viral Viral protein western blotting yield
[DOI] 10.1371/journal.pone.0262591 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 N Gene G29195T Point Mutation May Affect Diagnostic Reverse Transcription-PCR Detection

SARS-CoV-2 N 유전자 G29195T 점 돌연변이가 진단 역전사-PCR 검출에 영향을 줄 수 있음

Observation

Published on 2022-01-122022-09-10
Journal: Microbiology Spectrum
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding CDC clinical sample clinical samples complementary coronavirus detection diagnostic diagnostic escape diagnostic test diagnostic tests false-negative G29195T genome position Laboratory Mutation N gene nucleic acid nucleic acid sequences occur Point Point mutation Potential primer Primers probe probes Rapid Region respiratory reverse transcription RT-PCR RT-PCR assays SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 RT-PCR SARS-CoV-2 variant sequence severe acute respiratory syndrome Coronavirus Surveillance undetectable Viral viral genome viral genomes whole-genome sequencing
[DOI] 10.1128/spectrum.02223-21 PMC 바로가기 [Article Type] Observation

SARS-CoV-2 N Protein Induces Acute Lung Injury in Mice via NF-ĸB Activation

SARS-CoV-2 N 단백질은 NF-ĸB 활성화를 통해 쥐의 급성 폐 손상을 유발합니다

Immunology

Published on 2021-12-072022-09-11
Journal: Frontiers in Immunology
[Category] SARS, 치료법,

[키워드] acute lung injury acute respiratory syndrome addition administration antibody blocked body fluid body fluids Bone marrow C57BL/6 cell count Contamination coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines denaturation elevated expression in vitro induce Infection inhibitor Injury intratracheal administration lipopolysaccharide LPS lung Lung injury Macrophage macrophage polarization macrophages mice N-protein neutrophil neutrophil infiltration NF- kappa B nuclear nucleocapsid (N) protein nucleocapsid protein p65 pathway Phosphorylation Polymyxin B produced Proinflammatory cytokine proinflammatory cytokines promoted Protein PYRROLIDINE pyrrolidine dithiocarbamate recombinant reported respiratory Result SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid therapeutic target therapeutic targets toxic Treatment triggered
[DOI] 10.3389/fimmu.2021.791753 PMC 바로가기 [Article Type] Immunology