Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection Research Published on 2022-07-252022-10-05 Journal: Nature chemical biology [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] alleviate approach can be used cathepsin L Cell CRISPR decrease expression Host host protease in vivo infected with SARS-CoV-2 inhibitor interstitial inflammation knockdown Lower lung Messenger RNA mice mRNA pathological changes Potential treatment Prevent proinflammatory protease reduced reported SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis severity survival treat Treatment unique virus [DOI] 10.1038/s41589-022-01094-4 [Article Type] Research
Phylogenetic analysis and comparative genomics of SARS-CoV-2 from survivor and non-survivor COVID-19 patients in Cordoba, Argentina아르헨티나 코르도바에서 생존자와 비생존자 COVID-19 환자의 SARS-CoV-2 계통발생 분석 및 비교 유전체학Article Published on 2022-07-142022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis association B.1 both groups carried Clinical characteristics Clinical outcome clinical outcomes Comorbidities Comorbidity Comparative Comparative genomics Complete Córdoba coronavirus cough COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patient COVID-19 patients Dyspnea Epidemiological study Evolution Evolution of SARS-CoV-2 Fever First wave functional Future Genes genome sequence Genome sequences genomes Genomic analysis genomic data groups Hospitalization in both groups incidence Infectious diseases Lineage majority Molecular epidemiology Mutation nasopharyngeal specimen Next-generation sequencing nine non-survivor Non-survivors Nsp3 outcomes pandemic Patient patients performed phylodynamic Prevalence Protein repertoire Research respiratory responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation SARS-CoV-2 pathogenesis SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variants SARS-CoV-2 virus Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 South America Specific specific mutation specific mutations Spike protein Spread survivor Survivors Symptom Symptoms the SARS-CoV-2 the Spike variant Variation was performed [DOI] 10.1186/s12864-022-08756-6 PMC 바로가기 [Article Type] Article
Whole-genome analysis and mutation pattern of SARS-CoV-2 during first and second wave outbreak in Gwangju, Republic of Korea대한민국 광주에서 1차 및 2차 유행 중 SARS-CoV-2의 전체 게놈 분석 및 돌연변이 패턴Article Published on 2022-07-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis analyzed Cell culture circulating clade clinical clinical samples collected conducted Culture Deletion deletions determine dominant feature genetic diversity genomic genomic alteration high viral load in-depth analysis indicate Missense mutated Mutation Next-generation sequencing nucleic acid Nucleic acid purification outbreak Pathogenesis pathogenesis of SARS-CoV-2 Patient phylogenetic analyses Phylogenetic analysis Point mutation Proteins Region regions Research SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolates SARS-CoV-2 pathogenesis second wave significant difference South Korea statistical analysis therapeutic Viral load was performed whole genome [DOI] 10.1038/s41598-022-14989-y PMC 바로가기 [Article Type] Article
Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and TherapeuticsCOVID-19의 기계론적 모델: 질병 진행, 백신 및 치료제에 대한 통찰력Review Published on 2022-07-012022-09-11 Journal: International journal of antimicrobial agents [Category] 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] adaptive antiviral therapeutics antiviral therapy COVID-19 COVID-19 pandemic COVID-19 vaccines Critical develop Effectiveness global effort health system health systems Immunity Immunomodulatory agents impacted IMPROVE Infection innate and adaptive immunity insight mechanism Model outcome pandemic provided Quantitative quantitative systems pharmacology SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variants Significant Therapeutics Transmission Vaccine Vaccines viral dynamics Viral dynamics models. [DOI] 10.1016/j.ijantimicag.2022.106606 PMC 바로가기 [Article Type] Review
Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding regionACE2 결합 영역의 돌연변이에 의해 설계된 강력한 펩티드에 의한 SARS-CoV-2 발병 억제Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding allergenicity angiotensin Angiotensin-converting enzyme antiviral peptide binding energy complex Computational approaches COVID-19 COVID-19 treatment criteria deaths determined by Diagnosis docked domain Drug development effective inhibitor entry inhibitors Final host receptor identify information inhibition inhibitor inhibitory action initial Interaction mechanism molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation OSPREY outbreak pandemic peptide Peptide design Peptide inhibitor Peptide Inhibitors peptides provided RBD RBD binding RBD residue RBD residues RBD-ACE2 Receptor-binding domain residue residues SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 pathogenesis screened Spike protein spread of COVID-19 targeting Template the RBD Therapeutics Treatment vaccination variant Viral entry inhibitors. viral infection virus was determined [DOI] 10.1016/j.compbiomed.2022.105625 PMC 바로가기 [Article Type] Article
Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and OutcomeCOVID-19 사망률 환자의 상부 기도에서 증가된 Achromobacter xylosoxidans 및 Bacillus cereus는 질병 심각도 및 결과에서 공동 감염의 역할을 나타냅니다.Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] abundance Achromobacter Actinomyce Alter Analysis Antibiotic therapy approaches Bacillus cereus Bacterial bacterial species bacterial specy Care clinical manifestation Co-infection complementary complications of COVID-19 contribute COVID-19 COVID-19 patient current disease disease outcome disease pathology disease severity disease sub-phenotype Exacerbation Factor feature functional groups highlight Holo-Seq hospital host-pathogen interactions Increased Inflammatory response Inflammatory responses Integrative analysis investigated involved isolate isolates Leptotrichia mechanism Medical care metabolic pathways microbe microbial Mild mild COVID-19 patients moderate modulate modulating Mortality nasopharyngeal nasopharyngeal RNA outcome parameters pathogen pathogen genomics Patient patients phenotype Phenotypes Phylogenetic analysis progression provide question recovered patient recovered patients reported respiratory virus respiratory virus oligo panel (RVOP) role SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 pathogenesis Sequencing severe COVID-19 severe disease severity susceptibility Symptoms the disease the patient transcript transcriptionally transcriptionally active microbial isolates. Transmissibility upper vaccination variants variants of concern VoC window [DOI] 10.1128/spectrum.02311-21 PMC 바로가기 [Article Type] Article
SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral ReplicationSARS-CoV-2 N 단백질은 바이러스 복제를 촉진하기 위해 G3BP와 상호작용하여 스트레스 과립 조립 및 IFN 생산을 길항합니다Article Published on 2022-06-222022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] A549 cell line A549 cell lines Antiviral assembly betacoronaviruses bind causative agent contribute coronavirus disease Coronavirus disease 2019 COVID-19 Evidence G3BP1 G3BP2 global health Granule Health IFN in vitro in vivo Innate immunity interferon knockout mice knowledge live SARS-CoV-2 lung viral load mechanism mice N protein nucleocapsid nucleocapsid protein pandemic pathogenic pathogenicity Production Protein provide recent SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N SARS-CoV-2 pathogenesis SARS-CoV-2 virus SARS-CoV-2 virus infection SFTPC significantly higher Stress stress granule suppress the SARS-CoV-2 viral genome viral infection viral particle viral RNA genome virus infection viruses wild-type [DOI] 10.1128/jvi.00412-22 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic OptionsSARS-CoV-2 회피의 특성화: 인터페론 경로 및 치료 옵션Review Published on 2022-06-082022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antagonism Antiviral antiviral therapy characterization characterized circumvent contribute Control Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 patients Critical critical state drug dysregulated Efficacy evade explain expression Factor helping host innate immunity IFN IFN response IFN signaling pathway IFN-III IFNs in some individual Infection inhibit innate immune innate immune response Innate immunity interferon interferon-stimulated gene ISG mechanism new SARS-CoV-2 option pathogenicity Pathways pro-inflammatory cytokine responsible robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 the disease therapy treat Vaccines variant virus virus–host interactions [DOI] 10.3390/v14061247 PMC 바로가기 [Article Type] Review
The SARS-CoV-2 main protease doesn’t induce cell death in human cells in vitroSARS-CoV-2 주요 프로테아제는 시험관 내에서 인간 세포에서 세포 사멸을 유도하지 않습니다Article Published on 2022-05-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus addition analyzed antiviral therapies Apoptosis Cell cell death cell line cell lines contribute coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus replication COVID-19 Cytopathic effect cytotoxicity detect develop effective enzyme expression homologous human cell human cell lines in vitro inactivated induce molecular mechanism molecular mechanisms morphology multifunctional Pathogenesis protease Protein proteolytic activity required SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Spread the SARS-CoV-2 therapeutic target unlikely variant viability viral infection [DOI] 10.1371/journal.pone.0266015 PMC 바로가기 [Article Type] Article
Computational prediction of the molecular mechanism of statin group of drugs against SARS-CoV-2 pathogenesisSARS-CoV-2 병인에 대한 약물의 스타틴 그룹의 분자 메커니즘의 컴퓨터 예측Article Published on 2022-04-142022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] antiviral efficacy binding affinity Clinical data Clinical outcome complex computational analysis contribute COVID-19 patient COVID-19 patients Critical Delta docking docking score docking tool drug fluvastatin functional protein Helicase highest affinity indicated inhibit SARS-CoV-2 mechanism molecular dynamics Molecular dynamics simulation molecular mechanism Mortality mutant mutant proteins mutants Pathogenesis performed pitavastatin predict protease Protein protein complex Proteins reduction in risk RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 pathogenesis Spike proteins spike variants statin statins target protein target proteins the Spike therapy VOCs wild type [DOI] 10.1038/s41598-022-09845-y PMC 바로가기 [Article Type] Article