SARS-CoV-2 peptides bind to NKG2D and increase NK cell activitySARS-CoV-2 펩타이드는 NKG2D에 결합하여 NK 세포 활성을 증가시킵니다Article Published on 2022-01-012022-09-12 Journal: Cellular immunology [Category] MERS, SARS, 진단, [키워드] Activation acute respiratory syndrome binding cells coronavirus coronavirus disease COVID-19 cytotoxicity dysregulation Genes IFN-γ in silico analysis induce innate immune cell innate immune system Interaction interferon gamma lung cancer modulation natural killer NK NK cell NK cells NKG2D Patient peptide peptides Phosphorylation receptor receptors response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 S protein screened severe lung inflammation stimulated therapeutic target [DOI] 10.1016/j.cellimm.2021.104454 PMC 바로가기 [Article Type] Article
SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patientsSARS-CoV-2 재조합 단백질은 COVID-19 회복기 환자의 샘플에서 뚜렷한 세포 및 체액 면역 반응 프로필을 자극합니다Original Article Published on 2021-11-232022-09-10 Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens blood sample Blood samples CD3+ cellular Cellular immune response cellular immune responses cellular immunity chemiluminescence Contact contact with convalescent convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient Determination domain Donor ELISA ELISAs examined groups humoral humoral immune response Humoral response IFN-γ IgG antibodies IgG antibody Immune profile immune response immune responses Immunity individual individuals investigated Lymphocytes membrane nucleocapsid overlapping Patient peptide peptide pool peptide pools peptides pool profile Proteins RBD Receptor-binding domain Recombinant protein recombinant proteins regions respiratory S1/S2 SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike sequence serum serum IgG antibodies serum IgG antibody severe acute respiratory syndrome Coronavirus shown stimulate Stimulation T cell T cells T lymphocyte T lymphocytes volunteers [DOI] 10.6061/clinics/2021/e3548 PMC 바로가기 [Article Type] Original Article
High Frequencies of Functional Virus-Specific CD4 + T Cells in SARS-CoV-2 Subjects With Olfactory and Taste DisordersImmunology Published on 2021-11-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute phase Anosmia CD4 CD4 and CD8 CD8 clearance clinically control group COVID - 19 COVID-19 develop disorder evaluated extension Frequency functional granzyme B help IFN gamma IFNγ immune response Increased individual individuals interferon Lower respiratory tract Mild Mild symptom nasopharyngeal Outpatient Patient patients with SARS-CoV-2 peptide megapool presenting symptom robust SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 positive patient SARS-CoV-2 protein SARS-CoV-2 RNA secretion serology serum severe COVID-19 severe disease Severe infection spike spike-specific IgG Swab Symptom symptomatic T cell T cell response T-cell activation T-cell Response Taste the disease thought virus specific T cells Virus-specific IgG [DOI] 10.3389/fimmu.2021.748881 PMC 바로가기 [Article Type] Immunology
Mass spectrometric identification of immunogenic SARS-CoV-2 epitopes and cognate TCRs면역원성 SARS-CoV-2 에피토프 및 동족 TCR의 질량 분석 식별420 Published on 2021-11-012022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach best binding affinities caused cell lines cells cellular immune responses conserved coronavirus COVID-19 COVID-19 infection Critical defined effective elicit epitope Epitopes Evidence expressing glycoprotein histocompatibility complex humoral Humoral response humoral responses immune immune protection immune responses immunogenic immunogenicity In silico method in vitro increasingly Infection infectious kill killing major histocompatibility complex malignant disease malignant diseases mass spectrometric mass spectrometry membrane membrane glycoprotein MGP MHC MHC peptide nsp13 peptide peptides predict processed Protein recognize recognizing Region reported respiratory robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-CoV-2 peptide SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance specificity T cell T cell epitope T cell epitopes T cell response T cell responses T cells tandem Tandem mass spectrometry target cells TCR TCR-T the disease the SARS-CoV-2 therapy to define Treatment variants [DOI] 10.1073/pnas.2111815118 PMC 바로가기 [Article Type] 420
Ensemble Machine Learning Model to Predict SARS-CoV-2 T-Cell Epitopes as Potential Vaccine TargetsArticle Published on 2021-10-262022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome amino acid sequence amino acids antigenic antigenic protein Area assessments AUC average candidate caused coronavirus coronavirus disease COVID-19 cross determinant determinants effective Ensemble learning epitope experiment f-score help identify IEDB immune Immune Epitope Database in vitro in vivo inactive less machine learning machine learning classifier Model outbreak peptide peptide vaccine peptide-based vaccines physicochemical property Potential Precision predicted Probability Random forest repeated Repository retrieved robust ROC Curve SARS-CoV-2 SARS-CoV-2 peptide Scientific community sensitivity single-stranded RNA virus specificity T-cell T-cell epitope T-cell epitopes target target pathogen time-consuming Treatment Vaccine vaccine candidate Vaccine development voting ensemble was recorded worldwide pandemic [DOI] 10.3390/diagnostics11111990 PMC 바로가기 [Article Type] Article
Induction of High Levels of Specific Humoral and Cellular Responses to SARS-CoV-2 After the Administration of Covid-19 mRNA Vaccines Requires Several DaysImmunology Published on 2021-10-042022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] absence analyzed antibody B-cell BNT162b2 cellular cellular immune responses comparable COVID-19 cytokine Day disease effective Efficacy explain healthy humoral immune response Immunity immunization induce induction Infection infection risk Level medication Mortality mRNA mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine mRNA-vaccines objective pandemic Prevent Prophylactic Protective protective immunity provide receiving reduce required response Result robust SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2-specific T cell second dose secreted Specific specific humoral response Specific T-cell response spike-specific IgG T cell T-cell Response T-cell responses the disease the spike protein the vaccine Treatment unique vaccination vaccination schedule Vaccine Volunteer Whole blood [DOI] 10.3389/fimmu.2021.726960 PMC 바로가기 [Article Type] Immunology
Protein purification and crystallization of HLA-A∗02:01 in complex with SARS-CoV-2 peptidesSARS-CoV-2 펩타이드와의 복합체에서 HLA-A*02:01의 단백질 정제 및 결정화Article Published on 2021-09-172022-09-11 Journal: STAR protocols [Category] SARS, 치료법, [키워드] Antigen can be used Complete complex crystallization Crystallography expression HLA HLA class I HLA class I molecules Human Leukocyte Antigens immunology leukocyte nucleocapsid protein peptide peptides protein expression Protein expression and purification Protein purification protocol purification SARS-CoV-2 peptide T-cell Response T-cell responses the SARS-CoV-2 understanding viral peptide viral peptides X-ray X-ray crystallography [DOI] 10.1016/j.xpro.2021.100635 PMC 바로가기 [Article Type] Article
Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvementCOVID-19와 자가면역의 해결: 그럴듯한 표적의 식별은 다기관 관련을 시사합니다Article Published on 2021-09-012022-09-12 Journal: Molecular immunology [Category] MERS, SARS, 진단, [키워드] acting autoantibody autoantigen autoimmune condition autoimmune conditions Autoimmunity B cell epitope conserved COVID-19 COVID-19 patient demonstrated displaying distribution exacerbated explain homologous human protein Hypothesis identification Inflammation management manifestation mechanism molecular molecular mimicry multi Multi-organ damage Occurrence organ Region reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 proteins subsequent symptoms of COVID-19 target tissue triggering widespread [DOI] 10.1016/j.molimm.2021.06.021 PMC 바로가기 [Article Type] Article
Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individualsArticle Published on 2021-08-282022-11-01 Journal: Science Immunology [Category] COVID-19, MERS, SARS, [키워드] activated Activation activity Adults Amino acid amino acids CD4 CD8 Cell cell fate complex Control cytosolic deficiency Degradation effector T cell ENhance expression favor follicular Genes Immunity impair in vitro inactivation increased expression independent individual individuals Infection inhibiting late endosome leucine lysosomal lysosome Lysosomes mammalian memory T memory T cells mTORC1 negative feedback loop Older plasma membrane platform prevented proliferative Rapamycin recall reduced response responses resulting SARS-CoV-2 peptide SLC7A5 sustained T cell T cell activation T cell response T helper cell terminally differentiated TFEB transcription factor transfer VPS39 [DOI] 10.1126/sciimmunol.abg0791 PMC 바로가기 [Article Type] Article
PopCover-2.0. Improved Selection of Peptide Sets With Optimal HLA and Pathogen Diversity CoverageImmunology Published on 2021-08-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] allelic coverage Antigen approaches binding CD4 CD8 Coverage diagnostics Diversity effective epitope selection HIV HLA HLA allele frequencies HLA class I HLA class II identify immunogenic potential Improved information leukocyte offer pathogen pathogen coverage peptide peptide pool peptides polymorphism predicted rational epitope selection SARS-CoV-2 SARS-CoV-2 infected individuals SARS-CoV-2 peptide selected Selection subset T cell T cell epitope T cell response Vaccine Vaccine design variant whole protein [DOI] 10.3389/fimmu.2021.728936 PMC 바로가기 [Article Type] Immunology