Concordance of B- and T-cell responses to SARS-CoV-2 infection, irrespective of symptoms suggestive of COVID-19Article Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, [키워드] absence Analysis anti-IgG antibodies antibody Antibody titer Cellular immune response cellular immunity Cohort correlated correlated strongly COVID COVID-19 COVID-19 pandemic ELISA Evidence Final First wave IgG individual pandemic participant positive antibody response Regulatory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV2 infection spike Symptom symptom response. symptomatic and asymptomatic T cell T-cell T-cell Response TwinsUK were assessed [DOI] 10.1002/jmv.28016 PMC 바로가기
A fast and sensitive absolute quantification assay for the detection of SARS-CoV-2 peptides using parallel reaction monitoring mass spectrometry병렬 반응 모니터링 질량 분석을 사용한 SARS-CoV-2 펩타이드 검출을 위한 빠르고 민감한 절대 정량 분석Article Published on 2022-08-152022-09-11 Journal: Journal of proteomics [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] Absolute quantification Clinical diagnosis clinics COVID-19 Ct values Early detection enrichment heat heat-inactivated high resolution high viral load investigated mass mass spectrometry Nasopharyngeal swab nasopharyngeal swab sample Orbitrap pandemic Patient peptide peptides positive positive patient positive patients PRM Protein quantification required RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid SARS-CoV-2 peptide sensitivity speed Surveillance swab samples the disease Viral load Viral protein Viral proteins [DOI] 10.1016/j.jprot.2022.104664 PMC 바로가기 [Article Type] Article
Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID장기간 코로나바이러스에 감염된 혈청 음성 환자의 이전 SARS-CoV-2 감염의 증거Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute illness antibody assay Cambridge Cohort Consensus COVID COVID-19 illness Definition detectable Diagnosis diagnostic Evidence evidence of IFN-γ IL-2 Immunity infected with SARS-CoV-2 Innovation Long Long COVID Medical Research Council MRC NHSBT NIHR non-hospitalised Patient patients peptides positive PCR test Research reveal SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 peptides seronegative patient seronegative patients supported Symptoms T cell T cell response T cell responses T cells tested Trust United Kingdom Wellcome Trust [DOI] 10.1016/j.ebiom.2022.104129 PMC 바로가기 [Article Type] Article
T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article
Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다Article Published on 2022-06-282022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used [DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article
Rituximab Impairs B Cell Response But Not T Cell Response to COVID-19 Vaccine in Autoimmune Diseases리툭시맙은 자가면역 질환에서 COVID-19 백신에 대한 B 세포 반응을 손상시키지만 T 세포 반응을 손상시키지 않습니다Article Published on 2022-06-012022-09-12 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence activated anti-spike antibody response anti-Spike IgG Antibody Response Autoimmune disease autoimmune disease patient BNT162b2 CD4 CD8 CD8 T cell cellular response control group COVID-19 COVID-19 vaccine cytokine dose flow cytometry functional healthy control healthy controls humoral Immunosuppressant immunosuppressants interferon-γ Messenger RNA mRNA Necrosis Neutralization assay neutralizing antibody not different Patient patients patients treated performed Pfizer-BioNTech proportion Responder response rituximab RTX SARS-CoV-2 peptide SARS-CoV-2 spike peptide shown staining T cell response the healthy the vaccine time treated vaccine dose [DOI] 10.1002/art.42058 PMC 바로가기 [Article Type] Article
High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escapeMHC II 펩티드 제시 능력의 고해상도 프로파일링으로 SARS-CoV-2 CD4 T 세포 표적 및 면역 탈출 메커니즘 밝혀Article Published on 2022-04-292022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alleles alteration arising CD4 comprehensive analysis effective response epitope High-resolution HLA class II HLA class II alleles Immune escape immune evasion in silico in viral limitation mammalian mass spectroscopy mechanism MHC MHC allele MHC alleles MHC class MHC class II MHC II MHC II alleles Mutation peptide peptides physiological function physiological functions platform Precision provide reduced reveal SARS-CoV-2 SARS-CoV-2 peptide sensitivity silico predictions strain T cell T cells target therapeutic use threat Threats throughput understanding viral strains [DOI] 10.1126/sciadv.abl5394 PMC 바로가기 [Article Type] Article
Immunogenic SARS-CoV-2 S and N Protein Peptide and Cytokine Combinations as Biomarkers for Early Prediction of Fatal COVID-19치명적인 COVID-19의 조기 예측을 위한 바이오마커로서의 면역원성 SARS-CoV-2 S 및 N 단백질 펩티드 및 사이토카인 조합Article Published on 2022-03-212022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, 치료법, [키워드] Activation analyzed Biomarker Biomarkers chemokines clinical outcomes convalescent COVID-19 patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 sera cytokine Cytokine activation Cytokines demonstrated difference fatal fatal COVID-19 fatality higher risk highest humoral immune response IgG IgM IgM antibody improve clinical outcomes indication knowledge likelihood longitudinal analysis marker N protein nucleocapsid Nucleocapsid phosphoprotein Patient peptide peptides prediction pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines quantified reactivity risk S protein SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 S selected serum serum sample serum samples severe coronavirus disease Surface glycoprotein Treatment [DOI] 10.3389/fimmu.2022.830715 PMC 바로가기 [Article Type] Article
Heterologous Immunity Between SARS-CoV-2 and Pathogenic BacteriaImmunology Published on 2022-01-272022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation acute respiratory syndrome Asymptomatic Bacterial bacterial pathogen bystander CD69 Cell co-culture coronavirus coronavirus disease COVID-19 cross-reactive cross-reactivity cytokine production Donor Effect elicited explain extension Heterologous heterologous immunity high variability IFN-γ IL-2 Immunity in silico in vitro individual induce mechanism memory T memory T cell non-structural protein offered outcome outcomes pathogen pathogenic bacteria peptide peptides proliferation recall recognize response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 vaccination SARS-CoV-2 vaccine sequence homology severity Spike protein T cell T cell response tested the SARS-CoV-2 the spike protein TNF vaccination [DOI] 10.3389/fimmu.2022.821595 PMC 바로가기 [Article Type] Immunology
Selection and T-cell antigenicity of synthetic long peptides derived from SARS-CoV-2Animal Published on 2022-01-112022-10-30 Journal: The Journal of General Virology [Category] COVID-19, [키워드] activate Activation Alpha Antigen antigenicity approach autologous beta coronavirus caused CD4+ CD8+ T cell Cluster conserved coronavirus demonstrated dendritic cell effective vaccine epitope HLA class I immunogenic in vitro individual induce leucocyte mononuclear cell other coronavirus outbreak pandemic PBMC peptide Peripheral blood Protein proteome Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 peptides Selection T-cell T-cell Response T-cells the SARS-CoV-2 the Spike Vaccine variants of SARS-CoV-2 virus [DOI] 10.1099/jgv.0.001698 PMC 바로가기 [Article Type] Animal