SARS-CoV-2 virus label-free electrochemical nanohybrid MIP-aptasensor based on Ni 3(BTC) 2 MOF as a high-performance surface substrate고성능 표면 기판으로 Ni 3(BTC) 2 MOF 기반 SARS-CoV-2 바이러스 표지 없는 전기화학 나노하이브리드 MIP-aptasensorArticle Published on 2022-07-192022-09-11 Journal: Mikrochimica Acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] aptamer BTC carbon Concentration Detection limit Dopamine electrochemical biosensor facilitated growth In situ Ni3(BTC)2 MOF increase in linear relationship MIP MOF molecular Molecularly imprinted polymer Polymer S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus SARS-CoV-2, covid 19. Screen selective the SARS-CoV-2 virus transfer virus [DOI] 10.1007/s00604-022-05357-8 PMC 바로가기 [Article Type] Article
Comparative evaluation of flavonoids reveals the superiority and promising inhibition activity of silibinin against SARS-CoV-2플라보노이드의 비교 평가는 SARS-CoV-2에 대한 silibinin의 우수성과 유망한 억제 활성을 나타냅니다Article Published on 2022-07-012022-09-11 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] amino acids antiviral activity binding binding affinity Comparative Compound enzyme Enzyme inhibition evaluated exhibited FDA-approved drug flavonoid flavonoids followed by highest highest binding affinity in silico in silico study in vitro in vitro evaluation in vitro study indicated inhibition activity inhibition assay Interaction interfere key amino acid key amino acids M pro mammalian cell mapping molecular docking plant plants protease Protein RdRP Replication reveal S protein Safe SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein SARS-CoV-2 S protein Screening selectivity index Serine significantly silibinin silibinin. systematic literature search targets TMPRSS2 transmembrane serine protease virucidal was tested [DOI] 10.1002/ptr.7486 PMC 바로가기 [Article Type] Article
Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization인간 또는 동물 ACE2 매개 바이러스 진입 및 중화에 대한 우려의 SARS-CoV-2 변이체에서 스파이크 돌연변이의 영향Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal animals antibodies antibody Antibody neutralization antibody neutralization activity Beta caused cell entry cell line cell lines circulating common strain comparable concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Delta determine Effect Effectiveness Efficiency Express expressing global health Health host range Human human ACE2 Impact infect infecting information mink MOST Mutation neutralization neutralizing antibody Neutralizing titer neutralizing titers nine omicron Omicron variant over pandemic parental Protein pseudovirus pseudoviruses public policy reduced respiratory reveal S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significantly socioeconomics spike spike mutations Spread Substitution substitutions Support susceptible tested the S protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic therapeutic antibodies Transmissibility Transmission Vaccine variant variants variants of concern variety Viral viral cell viral entry viral neutralization virulence virus virus entry virus replication Virus replication. VoC VOCs zoonotic [DOI] 10.1128/spectrum.01789-21 PMC 바로가기 [Article Type] Article
Intranasal immunization with avian paramyxovirus type 3 expressing SARS-CoV-2 spike protein protects hamsters against SARS-CoV-2 Research Published on 2022-06-282022-10-05 Journal: NPJ Vaccines [Category] 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome Administered Beta clinical development controls coronavirus current domain dose Express expressing hamster hamsters Human IgA response Immunity immunization immunized immunogenic intranasal lack Lineage Lower respiratory tract Lung inflammation neutralized pre-existing immunity prefusion conformation proline substitution PROTECT Protective Protein replicated Replication respiratory tract response S-2P SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S protein SARS-CoV-2 spike protein serum IgG Serum neutralizing antibody stability stimulate the S protein the SARS-CoV-2 undetectable upper respiratory tract Vaccine vaccine candidates variants of concern WA1/2020 weight loss [DOI] 10.1038/s41541-022-00493-x [Article Type] Research
Human Intramuscular Hyperimmune Gamma Globulin (hIHGG) Anti-SARS-CoV-2-Characteristics of Intermediates and Final Product인간 근육내 과면역 감마 글로불린(hIHGG) 항-SARS-CoV-2-중간체 및 최종 제품의 특성Article Published on 2022-06-172022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-N antibodies anti-RBD anti-SARS-CoV-2 antibody Antibody titer Concentration convalescent convalescent plasma COVID-19 defined determine enzyme Final four-parameter nonlinear regression Gamma gamma globulin Globulin Human human intramuscular hyperimmune gamma globulin anti-SARS-CoV-2 (hIHGG anti-SARS-CoV-2). hyperimmune IgA IgG IgM immunoassay inactivated inactivation intermediate intramuscular material NAb Neutralization assay neutralization titer neutralizing antibody plasma product pseudovirus Result Sample SARS-CoV-2 SARS-CoV-2 S protein significantly stability undetectable was reduced were expressed [DOI] 10.3390/v14061328 PMC 바로가기 [Article Type] Article
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation Research Published on 2022-06-082022-10-05 Journal: Nature chemical biology [Category] COVID19(2023년), SARS, 치료제, [키워드] Activation airways binding pocket canonical cleaved effort explain feature half-maximal inhibitory concentration host cell identify implicated Infection inhibit inhibitor mechanism membrane fusion nonspecific pathogenesis of SARS-CoV-2 protease Protease inhibitor Protein proteolytic activity provide S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 S protein serine 2 specificity spike Structure the SARS-CoV-2 TMPRSS2 TMPRSS2 protease viral entry X-ray [DOI] 10.1038/s41589-022-01059-7 [Article Type] Research
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Research Published on 2022-06-062022-10-05 Journal: Cell Discovery [Category] 변종, 치료제, [키워드] activated acute respiratory syndrome approach blocked cathepsin Cell cleavage site conformations conserved coronavirus CTSL CTSL cleavage demonstrated domain Effect Ex vivo exhibited experiment host protease human donor Infection inhibitor Live virus lung tissue mechanism membrane fusion mice mutated novel omicron Prevent promoted Protein pseudovirus RBD reduced S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants strain the S protein therapy Treatment treatment strategy Vaccine variant viral infection virus [DOI] 10.1038/s41421-022-00419-w [Article Type] Research
Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor팔미토일에탄올아미드(PEA)는 S 단백질 및 ACE-2 수용체와 상호작용하여 SARS-CoV-2 진입을 억제합니다Article Published on 2022-05-172022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 activate activated adjuvant therapy Antiviral antiviral agent antiviral drug antiviral drugs antiviral potency binding bioactive lipids cascade cause cellular clinical test Clinical tests clinical trial connection Coronaviruses counteract Course COVID-19 COVID-19 pandemic Degradation derangement Disruption drop droplets energy entry receptor event Evidence fatty Fatty acid generate glycoprotein Glycoproteins highlight Huh-7 cells humans in viral Infection Inflammation inflammatory stimuli lack life cycle Lipid lipid droplets lipid metabolism lipids mechanism of action mechanisms membrane metabolism nutraceutical palmitoylethanolamide Pathways PEA Prevent protective effect Protective effects recent replicate Replication Research RNA virus S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein second significantly Spike protein spike protein. the SARS-CoV-2 therapy Toxicity transcription factor Treatment Usage viral infection viral life cycle virus viruses VSV [DOI] 10.3390/v14051080 PMC 바로가기 [Article Type] Article
A database for retrieving information on SARS-CoV-2 S protein mutations based on correlation network analysis상관 네트워크 분석을 기반으로 SARS-CoV-2 S 단백질 돌연변이에 대한 정보를 검색하기 위한 데이터베이스Article Published on 2022-05-042022-09-11 Journal: BMC Genomic Data [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha alpha and delta variants Analysis analysis Atypical Characteristics Combination correlation Correlation network COVID-19 COVID-19 infection COVID-19 infections database Delta variants Evolution Frequency Genome include individual Infection information Local Mu variant Mutation mutations network network analysis over Phylogenetic tree provide recall S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2. South America the S protein These data Transmission dynamics variant variants virus [DOI] 10.1186/s12863-022-01052-y PMC 바로가기 [Article Type] Article
Differences in Characteristics of T-Cell Immunity to SARS-CoV-2 in Clinically Healthy Subjects임상적으로 건강한 피험자에서 SARS-CoV-2에 대한 T-세포 면역 특성의 차이Article Published on 2022-05-012022-09-11 Journal: Bulletin of experimental biology and medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Cell Characteristics clinically COVID-19 difference healthy volunteer Humoral immunity humoral immunity. IFNγ IgG IgG SARS-CoV-2 ORF3 overlapping peptide peptide pool peptide pools peptides Protein protein sequence S protein S protein peptide SARS-CoV-2 SARS-CoV-2 S protein Spike protein Stimulation subjects T cell T cells T-cell T-cell immunity the SARS-CoV-2 the spike protein three groups Viral protein Viral proteins virus [DOI] 10.1007/s10517-022-05508-0 PMC 바로가기 [Article Type] Article