Cross-Reactivity of SARS-CoV-2 Nucleocapsid-Binding Antibodies and Its Implication for COVID-19 Serology TestsArticle Published on 2022-09-142022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] Adequate Analysis analyzed antibody antibody tests B.1 can be used caused characterized conserved convalescent sera COVID-19 COVID-19 patient cross-reactive cross-reactivity diagnostic domain ELISA test epitope global pandemic Humoral immunity immunogenic Infection magnitude new coronavirus SARS-CoV-2 nucleocapsid Nucleocapsid phosphoprotein patients positive correlation Protein raised RBD Recombinant protein reduced SARS-CoV-2 SARS-CoV-2 strain selective sensitivity sera serology test serology tests spike Spread Test the SARS-CoV-2 Vaccine variants of concern virus VoC VOCs [DOI] 10.3390/v14092041 PMC 바로가기
A Glycosylated RBD Protein Induces Enhanced Neutralizing Antibodies against Omicron and Other Variants with Improved Protection against SARS-CoV-2 InfectionArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] Affect antibody production B.1.1.529 B.1.1.7 lineage B.1.351 B.1.427 B.1.429 B.1.617.2 Beta coronavirus COVID-19 COVID-19 vaccine Delta delta variant demonstrated develop disease severity domain effective effective vaccine Effectiveness Efficacy elicited enhanced enhanced protection epitope Epsilon Gamma global public health highlight human ACE2 immunized immunized mice immunodominant IMPROVE Improved improved neutralizing activity induce Lineage mice mutant mutated Mutation Neutralizing Neutralizing activity neutralizing antibody Neutralizing antibody titer Numerous omicron Omicron and other variants Other P.1 pandemic Prevent probe protection Protective Protein pseudotyped pseudovirus RBD RBD protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants shown significantly Strains subunit Subunit vaccine the receptor-binding domain threat Transmissibility Vaccine variant variants weight loss [DOI] 10.1128/jvi.00118-22 PMC 바로가기
Factors associated with neutralizing antibody levels induced by two inactivated COVID-19 vaccines for 12 months after primary series vaccinationArticle Published on 2022-09-092022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] age analyzed anti-SARS-CoV-2 antibody BBIBP-CorV blood sample booster dose booster doses change Chi-square China convalescent convalescent sera CoronaVac COVID-19 COVID-19 vaccine cross-sectional Cytopathic effect dose enrolled evaluated Factor Factors FIVE geometric mean concentration geometric mean titer GMC GMT immune immune persistence immunogenicity Immunoglobulin inactivated individual Influencing factors linear models Logistic regression NAb neutralizing antibody NIBSC nine number ranged real-world data recipient recipients sample sizes SARS-CoV-2 SARS-CoV-2 strain seropositive Seropositivity Sex Standard subject understanding vaccination Vaccine Vaccines Vero Cell were measured WHO Zhejiang [DOI] 10.3389/fimmu.2022.967051 PMC 바로가기
Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-viralsArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 binding affinity angiotensin-converting enzyme 2 Anti-viral antivirals binding biosynthetic build candidate Cell D614G mutation displaying dissemination EC50 EC50 value fusion protein generate hamsters high stability in vitro Infection Interaction mitigate motif nasal nasal epithelium neutralisation activity neutralization neutralized Omicron variants overlapping promote Protein protein sequence proximal RBD Receptor binding domain recognizing reduced Replication SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants selected targeting the RBD the SARS-CoV-2 trivalent virus virus entry [DOI] 10.1371/journal.ppat.1010799 PMC 바로가기
Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19Research article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] association B.1 lineage candidate gene case-control study CCL2 cohort of patient contribute COVID-19 COVID-19 case COVID-19 severity Cytokine storm examined genetic loci genetic marker Genetic variant Genome Genome-wide association study genotyped Germany GWAS healthy control Hospitalization Hospitalized Host Host genetic factor host genetics investigated Lineage LZTFL1 MOST objective Pathogenesis patients with COVID-19 phenotype Phylogeny polygenic risk score predict reached reconstructed Result risk risk score SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 strain sequenced severity severity of COVID-19 significantly single nucleotide polymorphisms susceptibility the SARS-CoV-2 genome variant with COVID-19 [DOI] 10.1016/j.ijid.2022.06.030 [Article Type] Research article
Detection of SARS-CoV-2 clade B.1.2 in three snow leopardsArticle Published on 2022-09-012022-11-15 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Analysis basic reproduction number clade Clinical sign coronavirus correlated detection event excluded faece help hosts humans infect influenza viruses Lineage pandemic Panthera uncia Pathogenesis reservoirs SARS-CoV-2 SARS-CoV-2 strain Seven snow leopard Strains Testing Transmission viral shedding virus [DOI] 10.1111/tbed.14625 PMC 바로가기
Importance of external quality assessment for SARS-CoV-2 antigen detection during the COVID-19 pandemicCOVID-19 전염병 동안 SARS-CoV-2 항원 검출을 위한 외부 품질 평가의 중요성Article Published on 2022-09-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome analysed Antigen antigen test antigen tests approval automated circulating Combination concentrations country COVID-19 COVID-19 pandemic COVID-19 testing dataset datasets Deletion evaluate False negative false negatives Genetic immunoassays Importance in viral inactivated increase in independent Laboratory Lateral mutant Panel participant point-of-care test Quality Quality assurance rapid antigen test Registered Regulatory reported required respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variants sensitivity Severe acute respiratory syndrome shown strain Support Surveillance variants variants of concern Viral viral loads VOCs [DOI] 10.1016/j.jcv.2022.105222 PMC 바로가기 [Article Type] Article
Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster modelsArticle Published on 2022-09-012022-11-15 Journal: EBioMedicine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Alpha variant Anti-vector immunity applicability benefit cellular immunity coronavirus COVID-19 vaccine Dual vaccine Efficacy evaluated Fever hamster hamsters highly pathogenic humoral Immunity induce Infection interfere Liver disease mice platform pre-existing immunity PROTECT resulting SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 vaccines single dose subsequent vaccination Vaccine vaccine candidate Vaccines Viral vector vaccine virus virus infection yellow fever Yellow fever vaccine. [DOI] 10.1016/j.ebiom.2022.104240 PMC 바로가기
RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC ChallengeArticle Published on 2022-08-312022-11-15 Journal: mSphere [Category] SARS, 변종, 진단, [키워드] alleviate alum aluminum Antigen approved Beta Brain challenge Combination composed contributed country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines cross-reactive demonstrated development distribution dose Efficacy evaluated functional HBsAg help hepatitis B hydroxide immunization immunized immunogenic Inflammation K18-hACE2 K18-hACE2 mice lung mice mRNA mRNA vaccination mRNA vaccine neutralizing antibody offer pandemic Pfizer platform profile PROTECT protein subunit vaccine provided RBD RBD IgG RBD-VLP Receptor binding domain SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SpyCatcher SpyTag survival SWE Vaccine Vaccines Viral RNA VLP VLP vaccine VoC Wuhan [DOI] 10.1128/msphere.00243-22 PMC 바로가기
A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 InfectionSARS-CoV-2 감염에 대한 항바이러스제의 효능을 평가하기 위한 SCID 마우스 모델Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug antiviral drugs antiviral efficacy antivirals B.1.351 B.1.351 variant BALB/c Beta Beta variant binding C57BL/6 CAGE coronavirus Culture drug hamsters Infection infectious virus titer infectious virus titers Infective dose inhibitors intrinsic lack log lung Lung pathology Lungs male mice Model moderate molnupiravir mouse mouse model Mouse models Nirmatrelvir offer Postinfection reagent receptor reduced replicate Replication reported SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain SARS-CoV2 SCID significantly TCID These data tissue tissue culture twice a day Validity variant variants variants of concern Viral load virus virus strain wild-type [DOI] 10.1128/jvi.00758-22 PMC 바로가기 [Article Type] Article