IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2기억 B 세포에서 파생된 IgM 항체는 SARS-CoV-2의 강력한 교차 변형 중화제입니다Article Published on 2022-09-052022-09-11 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 변종, 진단, [키워드] affinities affinity Antigen B cell receptor convalescent convalescent sera domain Donor donors Efficacy Epitopes highlight Humoral immunity IgG IgG antibodies IgG antibody IgM IgM antibody immune memory Immunity mAb mAbs memory memory B cell memory B cells monoclonal antibody monomeric neutralizing antibody neutralizing capacity pathogen polyclonal sera responsible retained SARS-CoV-2 SARS-CoV-2 viral therapeutic potential variant Viral while [DOI] 10.1084/jem.20220849 PMC 바로가기 [Article Type] Article
Application of Statistical Learning to Identify Omicron Mutations in SARS-CoV-2 Viral Genome Sequence Data From Populations in Africa and the United StatesArticle Published on 2022-09-012022-11-15 Journal: JAMA Network Open [Category] SARS, 변종, 치료기술, [키워드] application applied assist averaged case sery collected detect detectable disease distribution effort evaluate exceeded Genome sequences genomic sequence help IMPROVE individual investigated learning Lineage OCP omicron outcome percentage Population SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral sequence South Africa statistical suggested Surveillance the United State The United States threshold variant viral sequences [DOI] 10.1001/jamanetworkopen.2022.30293 PMC 바로가기
Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical TrialArticle Published on 2022-09-012022-11-15 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis antibody blinded clinical COVID-19 Delta diagnosed Diagnosis double-blind Efficacy Elecsy evaluate evaluated had no higher odd immunoassay increase in Infection Infectious disease injection median Moderna mRNA-1273 occurred Odds ratio Older omicron participant PCR PCR-confirmed COVID-19 phase Phase 3 Placebo placebo recipient placebo-controlled polymerase chain Randomized risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Seroconversion serum sample severe COVID-19 Swab tested The United States Treatment Trial vaccination Vaccination Status Vaccine vaccinee [DOI] 10.7326/M22-1300 PMC 바로가기
Performance of 22 Rapid Lateral Flow Tests for SARS-CoV-2 Antigen Detection and Influence of “Variants of Concern”: Implications for Clinical UseArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome Alpha Antigen clinical collected coronavirus Cutoff cycle threshold detect detection evaluate evaluated exhibited false-positive result False-positive results Flow head-to-head assessment influence Lateral lateral-flow tests less majority NAAT nucleic acid amplification Occurrence Omicron variant Omicron variants other variants Paris performance proportion ranged Rapid reduced required SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 viral sensitivity Sensitivity and specificity specificity symptom onset Test tested variants variants of concern Viral load Viral variants virus VoC [DOI] 10.1128/spectrum.01157-22 PMC 바로가기
Genetic Surveillance of SARS-CoV-2 Mpro Reveals High Sequence and Structural Conservation Prior to the Introduction of Protease Inhibitor PaxlovidArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CLpro acute respiratory syndrome Analysis analyzed Antiviral antiviral drug Antiviral treatment antivirals baseline binding circulating cleavage clinical response conservation conserved Contact Coronaviral Coronaviridae family coronavirus COVID-19 COVID-19 pandemic Critical database determine drug target effort Emergency use authorization enzyme escape mutation EUA Evolution expected Genetic genomic GISAID globe health emergency implication inhibitor inhibitors initiative introduced isolate isolates M pro motifs MPro Mutation Nirmatrelvir pandemic progresse Paxlovid protease purifying selection raise reference sequence Region remained residue retrieved robust SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 Mpro SARS-CoV-2 viral selective sequence Sequencing starting point Surveillance the SARS-CoV-2 the spike protein Treatment unique variants variants of SARS-CoV-2 virus widespread Wuhan-Hu-1 [DOI] 10.1128/mbio.00869-22 PMC 바로가기
Detection of SARS-CoV-2 in Cancellous Bone of Patients with COVID-19 Disease Undergoing Orthopedic Surgery: Laboratory Findings and Clinical ApplicationsArticle Published on 2022-08-252022-11-15 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] absence aerosol analyzed application bone Cancellous cancellous bone clinical collected data conducted consecutive patient COVID-19 COVID-19 disease cycle detection equipment laboratory finding nasal swab Nasopharyngeal swab operative operative room orthopedic orthopedic surgery Patient PCR-based assays positive PPE Prevalence produced prospective observational study PROTECT recovered patients respiratory tract risk risk of infection RNA RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral suffered surgeon threshold tissue Tissue Bank viral genome was determined with COVID-19 [DOI] 10.3390/ijerph191710621 PMC 바로가기
Allelic Variations in the Human Genes TMPRSS2 and CCR5, and the Resistance to Viral Infection by SARS-CoV-2인간 유전자 TMPRSS2 및 CCR5의 대립형질 변이와 SARS-CoV-2에 의한 바이러스 감염에 대한 내성Article Published on 2022-08-152022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] addition age allelic variant allelic variants analyzed CCR5 CCR5 gene Clinical course close contact Comorbidities Comorbidity conditions contact with correlation COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 infection demonstrated described determinant Disease progression disease severity Europe explain First wave Gender Genetic polymorphism genetic variability highest Human human genes human populations identify Italy life cycle male mortality rate mortality rates old age performed polymorphism predisposition progression resistance rs12329760 rs333 rs35074065. SARS-CoV-2 SARS-CoV-2 first wave infection SARS-COV-2 infection SARS-CoV-2 viral Sicily subject subjects TMPRSS2 TMPRSS2 gene viral infection virus virus infection with COVID-19 [DOI] 10.3390/ijms23169171 PMC 바로가기 [Article Type] Article
Risk Factors for Slow Viral Decline in COVID-19 Patients during the 2022 Omicron Wave2022년 오미크론 파동 동안 COVID-19 환자의 느린 바이러스 감소에 대한 위험 요소Article Published on 2022-08-042022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] Adult patients age Analysis Chronic kidney disease conducted COVID-19 Ct value Decline declined delta variant determine Factor Geriatrics highest hospitalised hyperlipidaemia hypertension independent risk factor Isolation Kidney disease Kinetics knowledge lowest Multivariate analysis Older age omicron Omicron variant Patient PSO remained retrospective cohort study risk factor Risk factors SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 viral shedding slow statistically significant termination the timing Univariate analysis vaccination variant Viral load viral shedding Wave [DOI] 10.3390/v14081714 PMC 바로가기 [Article Type] Article
Treatment with metformin glycinate reduces SARS-CoV-2 viral load: An in vitro model and randomized, double-blind, Phase IIb clinical trial메트포르민 글리시네이트로 치료하면 SARS-CoV-2 바이러스 부하 감소: 시험관 내 모델 및 무작위, 이중 맹검, IIb상 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] adaptive aligned Alpha caused Cell Clinical data clinical trial conducted control group coronavirus disease COVID-19 COVID-19 patients COVID-19 treatment dose doses double-blind drug effort Epsilon evaluate exposure to Health Health crisis highlight highlighting identify IIb in vitro in vitro model in vitro result in vitro study in vivo increased survival indicate inhibit metformin Metformin glycinate New coronavirus new coronavirus SARS-CoV-2 new treatment strategy new virus oxygen phase Randomized reduce reduced SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 viral load severe disease supplementary oxygen tested the SARS-CoV-2 therapeutic option treated Treatment Treatment effectiveness triggered variant variants of interest Vero E6 VERO E6 cells viral infection Viral load viral replication [DOI] 10.1016/j.biopha.2022.113223 PMC 바로가기 [Article Type] Randomized Controlled Trial
TMED3 Complex Mediates ER Stress-Associated Secretion of CFTR, Pendrin, and SARS-CoV-2 SpikeTMED3 복합체는 CFTR, Pendrin 및 SARS-CoV-2 스파이크의 ER 스트레스 관련 분비를 매개합니다Article Published on 2022-08-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis CFTR complex conditions Critical cystic fibrosis ER stress Evidence expression fibrosis gene silencing improves involved mechanism membrane protein Membrane proteins pathway pendrin pendrin. plasma membrane Protein Proteins recognize reduce reduces SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 viral secretion spike syndrome TMED TMED10 TMED2 TMED3 TMED9 transmembrane transmembrane protein Transport UPS [DOI] 10.1002/advs.202105320 PMC 바로가기 [Article Type] Article