Do preexisting antibodies against seasonal coronaviruses have a protective role against SARS-CoV-2 infections and impact on COVID-19 severity?계절성 코로나바이러스에 대한 기존 항체가 SARS-CoV-2 감염에 대한 보호 역할을 하고 COVID-19 중증도에 영향을 줍니까?Commentary Published on 2022-01-232022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] antibody COVID-19 Cross-protectivity Preexisting immunity protective role SARS-CoV-2 SARS-COV-2 infection sCoV seasonal coronavirus [DOI] 10.1016/j.ebiom.2022.103831 PMC 바로가기 [Article Type] Commentary
Seasonal Betacoronavirus Antibodies’ Expansion Post-BNT161b2 Vaccination Associates with Reduced SARS-CoV-2 VoC NeutralizationBNT161b2 백신 접종 후 계절 베타 코로나바이러스 항체의 확장은 SARS-CoV-2 VoC 중화 감소와 관련이 있습니다.Original Article Published on 2022-01-092022-09-10 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accompanied addition Alpha antibodies antibody Antigen Associate Asymptomatic Beta beta VoCs betacoronavirus binding binding and neutralizing antibodies BNT162b2 Cohort collected COVID-19 delta VoCs disease epidemiological Evidence expansion Health care Health care worker health care workers HKU1 IgG IgG response IgG responses induce Laboratory Mild NAb NAbs naïve naïve vaccinees neutralization neutralization ability neutralize Neutralizing antibodies neutralizing antibody OC43 protein domain Rapid recognize reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination seasonal seasonal coronavirus Serological assay serological assays Spike protein subject subsequent subunit subunits supplementary material the Spike vaccination Vaccine variants variants of concern virus VOCs Wuhan Wuhan-Hu-1 [DOI] 10.1007/s10875-021-01190-5 PMC 바로가기 [Article Type] Original Article
Estimating the duration of seropositivity of human seasonal coronaviruses using seroprevalence studiesResearch Article Published on 2021-12-212022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] acute respiratory syndrome antibody catalytic Catalytic model children circulating coronavirus Endemic epidemiological estimate FIVE force of infection human coronavirus Immunity Infection majority offer Older persistence Reinfection SARS-CoV-2 seasonal seasonal coronavirus seasonal coronavirus Seroconversion Seroprevalence viruses waning immunity [DOI] 10.12688/wellcomeopenres.16701.3 PMC 바로가기 [Article Type] Research Article
How immunity from and interaction with seasonal coronaviruses can shape SARS-CoV-2 epidemiology404 Published on 2021-12-032022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] 95% CI acute respiratory syndrome affected age Alter children circulating contribute coronavirus coronavirus Coronaviruses COVID-19 cross-protection determine distribution early phase England Epidemics explain First wave Frequency human coronavirus Immunity infections Interaction magnitude mathematical pandemic projection reduced SARS-CoV-2 SARS-CoV-2 epidemiology SARS-COV-2 infection SARS-CoV-2 transmission seasonal coronavirus seasonal coronaviruses Significance surveillance data susceptibility Testing Transmission Transmission model [DOI] 10.1073/pnas.2108395118 PMC 바로가기 [Article Type] 404
Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra LeoneansSierra Leoneans의 Covid-199 혈액 샘플에서 SARS-COV-2 및 MERS-COV에 대한 교차 반응성 항체Article Published on 2021-11-212022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age American Americans antibodies binding antibody binding Blood donors blood sample Blood samples collected Contact contribute coronavirus coronavirus Coronavirus-2 country COVID-19 COVID-19 case COVID-19 caseloads and deaths cross-protective immunity cross-react death Ebola enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes had more healthy blood donor healthy blood donors humans induce infect Lassa fever MERS-CoV MERS-CoV pseudovirus middle Middle Eastern respiratory syndrome coronavirus neutralized Neutralizing antibodies neutralizing antibody not differ pandemic pre-existing immunity pre-existing immunity to coronaviruses presence of antibody Protein pseudovirus neutralizing antibodies recombinant antigens reduced Region reported Reporting respiratory respiratory syndrome coronavirus response Result Sample SARS-CoV SARS-CoV-2 SARS-CoV-2 pseudovirus seasonal coronavirus seasonal coronaviruses Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Sex sub-Saharan Africa subject survivor The United States United States were assessed [DOI] 10.3390/v13112325 PMC 바로가기 [Article Type] Article
Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization기존 교차 반응성 항체 반응은 비활성화된 COVID-19 백신 유도 중화에 큰 영향을 미치지 않습니다Immunology Published on 2021-11-192022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome analyzed antibody Antibody Response collected conserved CoV COVID-19 COVID-19 vaccine cross-reactive antibody cross-reactive antibody immunity distribution dose epitope Evidence fluorescence intensity greater healthy volunteer Humoral immunity IgG and IgM Immunity immunization Impact inactivated Inactivated vaccine increase in intensity linear neutralization not differ participant peptide peptides pre-vaccination previous study produced Protective provide recent Region Research response responses responses against S2 subunit SARS-CoV-2 SARS-CoV-2 vaccine seasonal coronavirus seasonal coronavirus sera significantly stimulate the S protein vaccinee whole-virion SARS-CoV-2 vaccine [DOI] 10.3389/fimmu.2021.772511 PMC 바로가기 [Article Type] Immunology
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2기존의 중합효소 특이적 T 세포가 혈청 음성 반응을 일으키지 않는 SARS-CoV-2에서 확장Article Published on 2021-11-102022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] abortive infection accumulate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody binding Cell clades clearance of SARS-CoV-2 Cohort complex conserved contribute Coronaviridae coronavirus Coronavirus infection Coronavirus infections cross-protective detectable develop Endemic epitope expand exposure to HCoV HCW HCWs healthcare worker highlight IFI27 Immunological memory in vivo increase in individual Infection memory response memory T memory T cell Neutralization assay neutralization assays pandemic PCR refs Region Replication respiratory response responses RNA polymerase robust RTC SARS-CoV-2 SARS-COV-2 infection seasonal coronavirus Sequence conservation Seroconversion seronegative severe acute respiratory syndrome Coronavirus subclinical infection Support T cell T cells target targets tested the strongest these cell These cells transcribed Transcription Vaccine variant Viral viral control [DOI] 10.1038/s41586-021-04186-8 PMC 바로가기 [Article Type] Article
Humoral response to SARS‐CoV‐2 and seasonal coronaviruses in COVID‐19 patientsCOVID-19 환자의 SARS-CoV-2 및 계절성 코로나바이러스에 대한 체액 반응Research Article Published on 2021-11-082022-09-10 Journal: Journal of medical virology [Category] MERS, SARS, 치료법, [키워드] 229E acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody levels Antibody Response Antibody responses association both groups Cohort control group convalescent plasma coronavirus Coronaviruses correlated correlation COVID COVID‐19 patient Definition disease severity Donor elevated Evidence evidence of HCoV HCoV 229E high responder human coronavirus human coronaviruses humoral humoral immune response Humoral response immunoassay in both group individual Infection lead levels of antibodies levels of antibody no evidence of nucleocapsid Postinfection predisposition Prevalence Protein respiratory SARS‐CoV‐2 SARS‐CoV‐2 antibodies SARS‐CoV‐2 antibody SARS‐CoV‐2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus significantly symptom onset tested while [DOI] 10.1002/jmv.27427 PMC 바로가기 [Article Type] Research Article
Development of a rapid point-of-care test that measures neutralizing antibodies to SARS-CoV-2Article Published on 2021-11-042022-10-04 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, [키워드] ACE2 angiotensin-converting enzyme 2 assays baseline binding Blood COVID-19 COVID-19 vaccine demonstrated development dose individual individuals infected individual infected individuals Infection lateral flow lateral flow assay measure microneutralization mRNA vaccine neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody non-infected Patient patients with COVID-19 plasma point-of-care RBD receiving recipient respiratory virus Result ROC Curve SARS-CoV-2 SARS-CoV-2 microneutralization assay seasonal coronavirus second dose semi-quantitative sera tested the receptor-binding domain vaccine dose vaccine doses Whole blood [DOI] 10.1016/j.jcv.2021.105024 PMC 바로가기 [Article Type] Article
Coronavirus seasonality, respiratory infections and weatherResearch Article Published on 2021-10-262022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] ambient association average children Climate condition coronavirus coronavirus Coronavirus infection country COVID-19 database distribution driver England Epidemic exceeded immunological increase in Increased Infection influenza A introduced less measure occur occurred pandemic parameter Radiation reduce reduced respiratory respiratory infection respiratory viruses Result SARS-CoV-2 seasonal seasonal coronavirus seasonality significantly more specimen supplementary material Surveillance survival susceptible System temperature Transmission Travel viral infection Virus Disease Virus survival weather [DOI] 10.1186/s12879-021-06785-2 PMC 바로가기 [Article Type] Research Article