Noradrenergic Add-on Therapy with Extended-Release Guanfacine in Alzheimer’s Disease (NorAD): study protocol for a randomised clinical trial and COVID-19 amendments알츠하이머병(NorAD)에서 연장 방출 구안파신을 사용한 노르아드레날린성 추가 요법: 무작위 임상 시험 및 COVID-19 수정안에 대한 연구 프로토콜Article Published on 2022-08-012022-09-11 Journal: Trials [Category] 임상, [키워드] activities activity Add-on therapy addition Adrenergic receptor affected Alzheimer's disease Alzheimer’s disease approved assessment Attention attention deficit baseline Brain burden cholinesterase inhibitor clinical trial Cognition cognitive Combination combination therapy COVID-19 Daily daily living determine disease disorder double-blind dysfunction evaluate Evidence executive Follow-up function Guanfacine Guanfacine. hyperactivity IMPROVE include interview inventory involved locus measure Mild mild to moderate moderate modulating Neuropsychiatric NorAD noradrenergic observation outcome participant pathological change pathological changes pathway Pathways Placebo placebo group placebo-controlled Primary outcome randomised receive receptor Regulation secondary Secondary outcomes Study protocol Symptom symptomatic synergistic synergistic effect Test the placebo group thought Treatment treatment group Trial [DOI] 10.1186/s13063-022-06190-3 PMC 바로가기 [Article Type] Article
A Randomized Controlled Trial of Internet-Based Self-Help for Stress During the COVID-19 PandemicRandomized Controlled Trial Published on 2022-08-012022-10-05 Journal: The Journal of adolescent health : official public [Category] 임상, [키워드] Anxiety appear assigned cognitive-behavioral therapy college Controlled COVID-19 COVID-19 pandemic Depression Efficacy evaluated Follow-up greater group healthcare Mental moderate not differ pandemic participant Positive psychology predicted Primary outcome Randomly receive recruited reduction reductions in Resilience Secondary outcomes self-help significantly Stress Stressor Support Symptom Treatment usual care were assessed [DOI] 10.1016/j.jadohealth.2022.01.227 PMC 바로가기 [Article Type] Randomized Controlled Trial
Efficacy and effectiveness of SARS-CoV-2 vaccines for death prevention: A protocol for a systematic review and meta-analysis사망 예방을 위한 SARS-CoV-2 백신의 효능 및 효과: 체계적인 검토 및 메타 분석을 위한 프로토콜Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, meta-analysis, SARS, [키워드] adverse event all-cause mortality analyzed approved assessment Bia calculated case-control studies case-control study Cohort controlled trials COVID-19 death deaths effective Effectiveness Efficacy Egger eligible Evidence exploratory for inclusion forest plot forest plots funnel plot hazard hazard ratios heterogeneity Hospitalization incident independent intervals Intervention Meta-analysis Mortality Observational data outcome Placebo Prevent Primary outcome PROSPERO protocol Publication bia publication bias randomized control trial Randomized controlled trials RCT Record reducing Registered risk reduction SARS-CoV-2 vaccine SARS-CoV-2 vaccines Secondary outcomes Severe case severe cases statistical statistical test systematic review the vaccine the vaccines university vaccination Vaccination Status Vaccine visual inspection York [DOI] 10.1371/journal.pone.0265414 PMC 바로가기 [Article Type] Article
Are micro enemas administered with a squeeze tube and a 5 cm-long nozzle as good or better than micro enemas administered with a 10 cm-long catheter attached to a syringe in people with a recent spinal cord injury? A non-inferiority, crossover randomised controlled trial Research Published on 2022-07-272022-10-05 Journal: Spinal cord [Category] 임상, [키워드] 95% confidence interval Administered assigned blind blinded bowel Care Complete determine hospital non-inferiority non-inferiority margin objective outcome Primary outcome Quality of life randomised controlled trial Randomly reflected reported Result secondary secondary outcome Secondary outcomes sequence setting Spinal cord injury Treatment Treatment effectiveness were measured [DOI] 10.1038/s41393-022-00835-5 [Article Type] Research
Favipiravir and/or nitazoxanide: a randomized, double-blind, 2×2 design, placebo-controlled trial of early therapy in COVID-19 in health workers, their household members, and patients treated at IMSS (FANTAZE)Favipiravir 및/또는 nitazoxanide: IMSS(FANTAZE)에서 치료를 받는 의료 종사자, 가족 구성원 및 환자를 대상으로 한 COVID-19 조기 치료에 대한 무작위, 이중 맹검, 2x2 설계, 위약 대조 시험Randomized Controlled Trial Published on 2022-07-222022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 1:1 2×2 design absence Admission antimicrobial Antimicrobials Antiviral effect antiviral therapy Antiviral treatment antivirals appear assigned Asymptomatic blinded to treatment combination therapy Comorbidities Comorbidity Controlled trial COVID-19 COVID-19 disease disease double-blind early disease early phase early treatment example Favipiravir followed by Gender Genetic genetic mutation Health high risk Hospitalization Hypothesis in some include individuals Infection Inflammatory Influenza intensive care investigator investigators later phase morbidity and mortality Mutation mutation rate nitazoxanide obesity older patient outcome pandemic participant patients treated pharmacokinetics phase phase IIa Placebo placebo-controlled placebo-controlled clinical trial placebo-controlled trial positive presence or absence Prevent Primary outcome progression protocol randomised randomised controlled trial Randomized receive replicates SARS-CoV-2 secondary Secondary outcomes security Sepsis severe disease smoking status Social Security Stratification symptomatic symptomatic COVID-19 Symptoms tested the disease therapy those with comorbidity Toxicity treatment allocation Trial upper respiratory tract Viral load virus [DOI] 10.1186/s13063-022-06533-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Safety and efficacy of mesenchymal stem cells in severe/critical patients with COVID-19: A systematic review and meta-analysisArticle Published on 2022-07-092022-10-06 Journal: EClinicalMedicine [Category] 진단, [키워드] 95% CI adverse event AEs applied benefit cellular therapy China Chinese CNKI Cochrane Library control group Coronavirus disease-19 (COVID-19) COVID-19 Critical database Descriptive analysis development disease category dose doses Efficacy Efficacy and safety Egger Free heterogeneity in-hospital mortality in-hospital mortality rate Innovation less Mesenchymal stem cells Meta-analysis mortality rate MSC MSCs optics original Patient patients with COVID-19 Placebo plan Primary outcome Program reduce mortality Safe Safety Science searched Secondary outcomes significant difference small sample size standard care standard treatment stem cell stromal cell subgroup analysis Support systematic review technology the disease Tianjin Trade Treatment Trial two groups Valley was performed were used Wuhan [DOI] 10.1016/j.eclinm.2022.101545 PMC 바로가기 [Article Type] Article
Sofosbuvir with daclatasvir and the outcomes of patients with COVID-19: a systematic review and meta-analysis with GRADE assessmentdaclatasvir와 Sofosbuvir 및 COVID-19 환자의 결과: GRADE 평가를 통한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-012022-09-11 Journal: Postgraduate medical journal [Category] 임상, [키워드] Admission certainty of evidence chance clinical clinical pharmacology clinical recovery clinically control group Controlled trial COVID-19 daclatasvir database databases death defined estimate evaluate the effect ICU ICU admission IMV inception increase in Infectious diseases intensive care intensive care unit internal medicine intervention group Invasive mechanical ventilation lower mortality Meta-analysis moderate Mortality mortality rate outcome Patient patients with COVID-19 performed Primary outcome randomised controlled trial reduce mortality rate reduced reported risk ratio risk ratios risk reduction RRs secondary outcome Secondary outcomes sofosbuvir sofosbuvir/daclatasvir Standard of care systematic literature search systematic review Virology [DOI] 10.1136/postgradmedj-2021-140287 PMC 바로가기 [Article Type] Meta-Analysis
Safety and efficacy of convalescent plasma for severe COVID-19: a randomized, single blinded, parallel, controlled clinical study중증 COVID-19에 대한 회복기 혈장의 안전성 및 효능: 무작위, 단일 맹검, 병렬, 대조 임상 연구Randomized Controlled Trial Published on 2022-06-272022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI adjusted Admission anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 S1 IgG antibodies antibody antibody levels assigned benefit blinded clinical clinical study clinical trial conducted controlled clinical study convalescent plasma coronavirus disease Coronavirus disease 2019 COVID-19 CP plus standard therapy discharge dose early stage early stages Efficacy Estimated evaluate evaluated Follow-up hospital Hospitalization IgA IgA antibodies IgA antibody IgG increase in intensive care intensive care unit admission less mechanical ventilation Mortality MOST pandemic participant Patient patients per-protocol analysis plasma Primary outcome Primary outcomes Randomized receive reduce reduction reduction in S1 IgG Safe Safety SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants secondary outcome Secondary outcomes Seven severe coronavirus disease severe COVID-19 ST alone ST group Standard therapy symptoms onset the disease the SARS-CoV-2 the WHO therapeutic option titers transfused transfused plasma transfusion treat Variability variant Viral Viral load viral load reduction was obtained [DOI] 10.1186/s12879-022-07560-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
Protecting the mental and physical well-being of frontline health care workers during COVID-19: Study protocol of a cluster randomized controlled trialCOVID-19 기간 동안 최전선 의료 종사자의 정신적, 육체적 웰빙 보호: 클러스터 무작위 통제 시험의 연구 프로토콜Article Published on 2022-06-012022-09-11 Journal: Contemporary clinical trials [Category] COVID19(2023년), SARS, 임상, [키워드] acceptability addition AID anxiety symptoms assigned Burnout Cluster Controlled trial COVID-19 COVID-19 pandemic Depression disorder distress Effectiveness eight Evidence feasibility first aid HCW Health care Health care worker health care workers health center Healthcare workers hospital implementation include initial Injury Intervention Mental mental health Moral distress pandemic physical Posttraumatic Stress posttraumatic stress disorder Primary outcome Primary outcomes problems Protecting protocol Psychological Psychological distress Randomized controlled trial Randomly recruit Resilience Result risk secondary outcome Secondary outcomes selected Stress Support turn usual care Well-being [DOI] 10.1016/j.cct.2022.106768 PMC 바로가기 [Article Type] Article
Point-of-Care Ultrasound Predicts Clinical Outcomes in Patients With COVID-19현장 진료 초음파로 COVID-19 환자의 임상 결과 예측Article Published on 2022-06-012022-09-11 Journal: Journal of Ultrasound in Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] 24 hour 24 hours Admission Adult patients appear blinded clinical clinical implications Clinical outcome clinical outcomes collected conducted confidence interval consolidation consolidations COVID-19 criteria Critically ill critically ill patients detect discharge evaluate hospital ICU ICU admission inclusion criteria intensive care intensive care unit intubation less lung manifestation Mortality Odds ratio outcome outcomes oxygen Patient patients patients hospitalized POCUS predict Predictive Primary outcome prospective cohort study Protective protocol risk stratification secondary Secondary outcomes supplemental oxygen symptom onset Ultrasound [DOI] 10.1002/jum.15818 PMC 바로가기 [Article Type] Article