Expecting individuals’ body reaction to Covid-19 based on statistical Naïve Bayes techniqueResearch article Published on 2022-08-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 변종, [키워드] Accuracy affected average binary classification Classifier collected competing complications compose COVID-19 dataset diagnosing drastic Efficiency expectation feature Fisher Gray hybrid Improved include Infection introduced mutated virus Naïve Bayes occur optimization outlier outperform phase Precaution Precision predict prediction provide Prudential Expectation reached recall rejection routine blood test score selected Selection statistical Strategy subset training data virus Wolf Wrapper [DOI] 10.1016/j.patcog.2022.108693 [Article Type] Research article
Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infectionSARS-CoV-2 감염 진단을 위한 신속한 현장 진료 항원 검사Review Published on 2022-07-222022-09-11 Journal: The Cochrane database of systematic reviews [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval absence access Accuracy age Antigen antigen test antigen tests approach assays Asymptomatic average Bern bioRxiv brand can not carried Chain Reaction Characteristics checked CIs Cohort Compliance conducted COVID-19 COVID-19 pandemic COVID-19 testing criteria criterion Data collection database demonstrated described detect diagnosis of SARS-CoV-2 diagnostic Diagnostic accuracy diagnostic tests Effectiveness eligible epidemiological estimate Europe evaluate evaluated Evidence exposure to False positive False positives global health groups Health Organization healthcare help heterogeneity highest include independent indication Infection Interpretation investigated logistic regression models management Mass screening measure medRxiv molecular test National Open Access Other participant Participants Patient care point-of-care polymerase chain polymerase chain reaction population groups Positive predictive value positive result PPV Predictive value presence or absence Prevalence produced public health QUADAS-2 random-effect ranged Rapid rapid antigen test Rapid antigen tests Rapid diagnostic test reduce reducing reference reference standard Reference standards repeated reported Research respiratory respiratory sample resulting reverse transcription reverse transcription polymerase chain reaction RT-PCR RT-PCR testing SARS-CoV-2 SARS-COV-2 infection Schools screened screening procedure screening programmes searched second Selection sensitivities sensitivity Sensitivity and specificity Seven Signs and symptoms Source Specificities specificity study cohort Study design Symptom symptom onset symptom status symptomatic symptomatic and asymptomatic symptomatic participant symptomatic participants symptomatic people symptoms of COVID-19 test negative test result Testing to define Transmission Triage unique University of Bern variable Viral Viral load viral loads website were used WHO World Health Organization [DOI] 10.1002/14651858.CD013705.pub3 PMC 바로가기 [Article Type] Review
Causal Modeling to Mitigate Selection Bias and Unmeasured Confounding in Internet-Based Epidemiology of COVID-19: Model Development and ValidationCOVID-19의 인터넷 기반 역학에서 선택 편향과 측정되지 않은 교란을 완화하기 위한 인과 관계 모델링: 모델 개발 및 검증Article Published on 2022-07-212022-09-11 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] age applied approach Bia bias Causal Causality collected Community compatibility conditions Confounding confounding factors COVID-19 COVID-19 symptoms Critical cumulative demographic characteristics demographics design detect determine develop development Diagnosis Epidemic epidemiologic research design epidemiological Epidemiological study Epidemiology estimate Health status household infection implementation Infection infection rate internal and external Mechanical mechanism method mitigate Model modeling MTurk New New York New York City omicron Omicron variants problem protocol public health Qualtrics recent reported Research Research design response Selection selection bia Selection bias sensitivity sensitivity analysis skewed state subject Surveillance the disease Threats utility validation Validation. Validity variant [DOI] 10.2196/31306 PMC 바로가기 [Article Type] Article
In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance렘데시비르 내성 SARS-CoV-2의 체외 선택은 내성에 대한 높은 장벽을 보여줍니다Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] 50% effective concentration active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 barrier coronavirus in vitro increase in introduced Lineage Nsp12 Nsp12 polymerase nsp12 protein passage polymerase Protein remained Remdesivir resistance resistance. SARS-CoV-2 SARS-CoV-2 virus Selection [DOI] 10.1128/aac.00198-22 PMC 바로가기 [Article Type] Article
An Electrostatically-steered Conformational Selection Mechanism Promotes SARS-CoV-2 Spike Protein Variation정전기로 조종되는 구조적 선택 메커니즘은 SARS-CoV-2 스파이크 단백질 변이를 촉진합니다Article Published on 2022-07-152022-09-11 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 amino acids Analysis analyzed collected conformational conformational change conformational changes COVID-19 COVID-19 pandemic Critical Cross-species transmission epidemiological epidemiological surveillance Evolution fusion global public health global public health emergency HADDOCK heterogeneity host cell host cell receptor hydrophobicity identify immune evasion IMPROVE local interaction local interactions MOST outbreak promote Protein protein–protein interactions protein–protein interactions. Recognition recorded reducing Region replacing risk S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Selection sequence variation spike Substitution substitutions Surveillance the S protein trimer vaccination Vaccine development variant [DOI] 10.1016/j.jmb.2022.167637 PMC 바로가기 [Article Type] Article
SARS-Arena: Sequence and Structure-Guided Selection of Conserved Peptides from SARS-related Coronaviruses for Novel Vaccine DevelopmentSARS-Arena: 새로운 백신 개발을 위한 SARS 관련 코로나바이러스에서 보존된 펩티드의 서열 및 구조 유도 선택Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] 3D structure affected against SARS-CoV agent analysis approach can be used case study caused CD8 computational method Computational methods conserved contribute coronavirus COVID-19 disease cross-reactive database development envelope proteins help HLA HLA-Arena HLA-B7 Human human leukocyte antigen humoral Humoral response immune response less leukocyte mitigate MOST Multiple sequence alignment N protein Notebook novel nucleocapsid nucleocapsid protein pandemic peptide peptides pHLA scoring Practitioner practitioners Prevent Protein protein regions protein sequence protein sequence alignment protein sequences Proteins Region related viruses responsible SARS-CoV SARS-CoV viruses SARS-CoV-2 SARS-CoV-2 virus Selection selection pressure Sequence alignment Spike protein structural modeling. susceptible T-cell T-cells target the disease the N protein the SARS-CoV-2 virus the spike protein therapy Vaccine development Vaccines variants viral envelope protein viral strains viruses widespread [DOI] 10.3389/fimmu.2022.931155 PMC 바로가기 [Article Type] Article
Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID-19 Trial of NirmatrelvirNirmatrelvir의 중요한 COVID-19 시험을 가속화하고 알리기 위한 혁신적인 무작위 1상 연구 및 투여 요법 선택Clinical Trial Published on 2022-07-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] COVID19(2023년), SARS, 신약개발, 임상, 진단, 치료제, [키워드] accelerated Antiviral antiviral activity Clinical efficacy clinical trial Cohort cohorts Concentration Coronaviridae family coronavirus disease Coronavirus disease 2019 COVID-19 death decrease demonstrated dose Dosing double-blind enhancer evaluated FIVE half-life Hospitalization in vitro inhibitor M pro MAD modeling Nirmatrelvir PF-07321332 pharmacokinetic pharmacokinetic data phase Phase I Placebo placebo-controlled Prevent Quantitative Randomized regimen required Ritonavir Safe Safety safety profile SARS-CoV-2 SARS-CoV-2-infected patient SARS-CoV-2-infected patients seamless Selection Severe acute respiratory syndrome severe disease significantly suggested supported Tolerability Trial Viral load viral replication [DOI] 10.1002/cpt.2603 PMC 바로가기 [Article Type] Clinical Trial
Effect of Pulmonary Rehabilitation Approaches on Dyspnea, Exercise Capacity, Fatigue, Lung Functions, and Quality of Life in Patients With COVID-19: A Systematic Review and Meta-analysisReview article Published on 2022-07-012022-10-05 Journal: Archives of physical medicine and rehabilitation [Category] 임상, [키워드] 6-minute walk test 6MWT6-minute walk test 95% CI acute COVID-19 appear Capacity chronic obstructive pulmonary disease Controlled trial COPDchronic obstructive pulmonary disease COVID-19 COVID-19 patients database Dyspnea Effect effective evaluate the effect evaluated exercise Exercise capacity extraction fatigue feasible forced vital capacity functions FVCForced vital capacity independent indicate Intervention life lung Lung function mean difference Mild mild symptoms objective outcome outcome measure participant Patient patients with COVID-19 PRpulmonary rehabilitation pulmonary pulmonary rehabilitation QoLquality of life Quality Quality of life random effect Randomized controlled trial RCT RCTrandomized controlled trial RCTs review risk of bia Safe searched Selection severe symptoms SFShort-Form Health Survey SGRQSt. George's Respiratory Questionnaire Short-Form Health Survey significantly SMD Source St. George's Respiratory Questionnaire synthesis ventilatory Web of Science [DOI] 10.1016/j.apmr.2022.06.007 [Article Type] Review article
Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineagesOmicron 하위 계통을 포함하여 다양한 SARS-CoV-2 변이체에 대해 매우 효과적인 3회 용량 백신의 강력한 광범위 중화 항체의 선택 및 구조적 기반Article Published on 2022-07-012022-09-11 Journal: Cell Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] base effective neutralizing antibody omicron SARS-CoV-2 variants Selection vaccinee [DOI] 10.1038/s41422-022-00677-z PMC 바로가기 [Article Type] Article
Decoding clinical biomarker space of COVID-19: Exploring matrix factorization-based feature selection methodsCOVID-19의 임상 바이오마커 공간 디코딩: 매트릭스 인수분해 기반 특징 선택 방법 탐색Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] MERS, 바이오마커, 진단, [키워드] ABG Algorithm approach arterial arterial blood arterial blood gas Biomarker blood gas blood test blood tests C-reactive protein C-reactive protein (CRP Characteristics classification clinical Clinical biomarker clinical evidence Clinical management complex disease complex diseases COVID-19 COVID-19 crisis COVID-19 patient Critical Critical care CRP determine Dimensionality reduction Diseases Feature selection forest former global pandemic identify matrix Matrix factorization. morbidity path Patient patients performed poor prognosis Predictive Quantitative Random forest reveal saturation Selection unmet need [DOI] 10.1016/j.compbiomed.2022.105426 PMC 바로가기 [Article Type] Article