selectivity – Page 2 – Communicable Diseases Research

Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide-Based Hybrid Compounds against SARS-CoV-2 and Cancer

SARS-CoV-2 및 암에 대한 아르테미시닌/합성 과산화물 기반 하이브리드 화합물의 합성 및 시험관 내 연구

Article

Published on 2022-05-042022-09-11
Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제,

Comparative Greenness Metric Estimates for Content Uniformity Testing of Anti-Cov-2, GS-5734 in Commercial Vials: Validated Micellar Electrokinetic Chromatographic Assay

상업용 바이알에서 Anti-Cov-2, GS-5734의 함량 균일성 테스트에 대한 비교 녹색도 측정법 추정: 검증된 미셀 동전기 크로마토그래피 분석

Article

Published on 2022-04-272022-09-11
Journal: Journal of AOAC International [Category] 치료기술, 치료제,

[키워드] Analysis Antiviral antiviral drug antiviral properties antiviral property applied approved borate borate buffer can be used clinical trials Community Comparative content coronavirus correlation coefficient COVID-19 drug Drug administration Ebola Ebola virus effective estimate food green GS-5734 harmonization International Conference linear metric pandemic pharmaceutical industry phosphoramidate positive Remdesivir selectivity sensitivity silica sodium sodium dodecyl sulfate solvent sulfate Testing treat Treatment U.S. Food and Drug Administration uniformity urge viruses was used widespread
[DOI] 10.1093/jaoacint/qsac001 PMC 바로가기 [Article Type] Article

Rapid Detection of Anti-SARS-CoV-2 Antibodies with a Screen-Printed Electrode Modified with a Spike Glycoprotein Epitope

스파이크 당단백질 에피토프로 변형된 스크린 인쇄 전극을 사용한 항 SARS-CoV-2 항체의 신속한 검출

Article

Published on 2022-04-262022-09-11
Journal: Biosensors [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제,

[키워드] 2019 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody B-cell epitope capture caused Chagas disease Chikungunya Consequences coronavirus coronavirus disease COVID-19 cross-reaction Dengue detection diagnose diagnoses diagnosing Diagnostic method differentiation dilution factor electrochemical biosensor electrode epitope Final flexibility Health hydroquinone IgG immunocomplex Immunoglobulin Immunoglobulin G immunological immunological diagnostic individual Infection linear material Molecular biology non-infected other disease other diseases pandemic Pathogens patient sera point of care Rapid reaction required respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein SARS-CoV-2-specific IgG SARS-CoV-2-specific IgGs selectivity sera serological serum samples severe acute respiratory syndrome Coronavirus specificity spike spike glycoprotein Spike protein Spread synthesis the SARS-CoV-2 the spike protein variants of SARS-CoV-2 Volume was measured was selected
[DOI] 10.3390/bios12050272 PMC 바로가기 [Article Type] Article

Dual-site ligation-assisted loop-mediated isothermal amplification (dLig-LAMP) for colorimetric and point-of-care determination of real SARS-CoV-2

실제 SARS-CoV-2의 비색 및 현장 진단을 위한 이중 사이트 결찰 보조 루프 매개 등온 증폭(dLig-LAMP)

Article

Published on 2022-04-052022-09-11
Journal: Mikrochimica Acta [Category] COVID19(2023년), SARS, 치료기술,

Label-free duplex SAMDI-MS screen reveals novel SARS-CoV-2 3CLpro inhibitors

라벨이 없는 이중 SAMDI-MS 화면은 새로운 SARS-CoV-2 3CLpro 억제제를 보여줍니다

Article

Published on 2022-04-012022-09-11
Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제,

[키워드] 3CLpro activities acute respiratory syndrome Analysis Anti-viral Antiviral compound Antiviral compounds assays biochemical assay cathepsin cathepsin L cellular cytotoxicity chymotrypsin completion coronavirus COVID-19 cysteine cysteine protease described dose response evaluated feature gold High-throughput screening Human rhinovirus inhibitor mass mass spectrometry matrix monolayer optimization protease Protease inhibitor Proteases required reveal rhinovirus rhinoviruses SARS-CoV-2 selective selectivity Severe acute respiratory syndrome small molecule specific inhibitor structure activity relationship therapeutic target
[DOI] 10.1016/j.antiviral.2022.105279 PMC 바로가기 [Article Type] Article

Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-α with in-vitro effective drug ivermectin

in-vitro 효과적인 약물 Ivermectin과 Covid-19 및 importin-α의 확인 된 단백질 표적에 대한 결합 메커니즘 및 구조적 통찰력

Article

Published on 2022-03-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제,

Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

천연물 갈린아미드 A 및 카텝신 L의 억제를 통한 유사체에 의한 강력한 항-SARS-CoV-2 활성

Article

Published on 2022-02-242022-09-11
Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

Bacterial ligands as flexible and sensitive detectors in rapid tests for antibodies to SARS-CoV-2

SARS-COV-2에 대한 항체에 대한 빠른 시험에서 유연하고 민감한 검출기로서의 박테리아 리간드

Research Paper

Published on 2022-02-112022-09-01
Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술, 치료법,

[키워드] 95% CI Abstract Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition alternatives analyzed anti-SARS-CoV-2 antibodies antibody applied Bacterial binding Broad-specific ligands cats conjugate Coronavirus-2 defined Design of experiment detectable Diagnosis diagnostic diagnostic methods diagnostic sensitivity Diseases experimental design flexibility flexible fraction gold Gold nanoparticle Gold nanoparticles human serum immune response immunoassay immunodominant Immunoglobulin Infectious diseases Lateral lateral flow immunoassay LFIA LFIAs Ligand molecular nucleocapsid protein Patient POCT point-of-care test point-of-care tests positive Protein protein A Proteins Rapid test reactivity respiratory robustness SARS-CoV-2 selective selectivity sensitivity serological Serological testing serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Streptococcal supplementary material Typical Viral viral antigens with COVID-19
[DOI] 10.1007/s00216-022-03939-2 PMC 바로가기 [Article Type] Research Paper

An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking

SARS-CoV-2 스파이크의 확장된 모티프는 역행 인신매매에서 숙주 코토머의 결합 및 방출을 조절합니다

Article

Published on 2022-02-082022-09-10
Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 변종,

Robust validation and performance comparison of immunogenicity assays assessing IgG and neutralizing antibodies to SARS-CoV-2

SARS-COV-2에 대한 IgG 및 중화 항체를 평가하는 면역 원성 분석의 강력한 검증 및 성능 비교

Research Article

Published on 2022-02-072022-09-10
Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,

[키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 anti-SARS-CoV-2 spike protein antibody Antibody titer Antibody titers approach Benchmarking calibrated convalescent coronavirus coronavirus disease Coronavirus disease 2019 correlation criteria cross-reactivity demonstrated domain donors ECL functional functional immune response human serum IgG immune response immune responses immunogenicity immunogenicity assay immunogenicity assays immunogenicity data Immunoglobulin Immunoglobulin G International international units Meso Scale Discovery microneutralization MNT MSD multiplex Neutralizing activity Neutralizing antibodies neutralizing antibody nucleocapsid outcome Precision Protein Quantitative RBD RBD protein RBD proteins reference standard regimens Reporting respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike SARS-CoV-2 vaccination scale seasonal coronaviruses selectivity sera serologic severe acute respiratory syndrome Coronavirus specificity spike and RBD proteins Spike protein tested the WHO vaccinated individuals vaccination Vaccine Vaccines virus were assessed
[DOI] 10.1371/journal.pone.0262922 PMC 바로가기 [Article Type] Research Article