Serum amyloid P component is an essential element of resistance against Aspergillus fumigatusArticle Published on 2021-06-182022-10-04 Journal: Nature Communications [Category] 진단, [키워드] A. fumigatus activate Activation administration amyloid Aspergillus fumigatus Bacterial infection cascade classical pathway complement conidia death dependent on ENhance Evidence fungal Fungal infection Genetic variation Host humoral Immunosuppressed in vivo Infection Innate immune cells Innate immunity invasive involved Lungs mice neutrophil Neutrophils pathogen Pathogens phagocytosis PROTECT recruitment Regulation serum amyloid susceptibility tissue remodeling [DOI] 10.1038/s41467-021-24021-y PMC 바로가기 [Article Type] Article
Hypothesis: AA amyloidosis is a factor causing systemic complications after coronavirus disease가설: AA 아밀로이드증은 코로나바이러스 질병 후 전신 합병증을 유발하는 요인입니다Article Commentary Published on 2021-04-202022-09-10 Journal: Prion [Category] 바이오마커, [키워드] AA amyloidosis amyloid A amyloidosis Biomarker cause chronic inflammation clinical picture Complication consequence coronavirus coronavirus disease Course COVID-19 COVID-19 infection cytokine cytokine production Cytokines Factor form Hypothesis induce Inflammation mind occur organ organs overproduction Protein provoke SAA serum amyloid serum amyloid A severe COVID-19 shown thrombosis tissues variety [DOI] 10.1080/19336896.2021.1910468 PMC 바로가기 [Article Type] Article Commentary
Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort studyCOVID-19 유무에 관계없이 ICU 환자의 숙주 내피, 상피 및 염증 반응의 비교: 전향적 관찰 코호트 연구Observational Study Published on 2021-04-192022-09-11 Journal: Critical Care [Category] MERS, 바이오마커, 임상, [키워드] Acute kidney injury acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amyloid A angiopoietin biological pathway Biomarker Blood both groups cause cell injury characteristic collected Concentration coronavirus COVID-19 Critical Critical illness Critically ill demographics diagnose diagnoses end products endothelial Endothelial dysfunction enrolled epithelial epithelial cell evaluate followed by groups Host host response ICU admission ICU patient ICU Patients in both group in-hospital mortality Inflammation Inflammatory biomarker Inflammatory response interleukin interleukin 6 Invasive mechanical ventilation involved marker Mortality Necrosis Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients not different Pathways Patient plasma biomarker Pneumonia positive proportion prospective observational cohort Protein receptor respiratory respiratory distress Respiratory distress syndrome Respiratory failure Result resulting SAA SARS-CoV-2 SARS-COV-2 infection Sepsis serum amyloid severe acute respiratory syndrome Coronavirus severe COVID-19 significantly higher significantly lower sTNFR study enrollment supplementary material syndrome target targets Therapeutics Tumor tumor necrosis tumor necrosis factor Viral viral infection while [DOI] 10.1186/s13054-021-03547-z PMC 바로가기 [Article Type] Observational Study
Complement C3 identified as a unique risk factor for disease severity among young COVID-19 patients in Wuhan, ChinaArticle Published on 2021-04-122022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] 95% CI adverse outcome age Analysis analyzed C-reactive protein (CRP Characteristics clinical Clinical characteristics Clinical outcome collected Comorbidities Complement C3 covariate COVID-19 patient COVID-19 patients Critical disease course disease severity Diseases Elderly patient elderly patients elevated Factor female Gender independent influence influences interquartile range laboratory data lactate dehydrogenase LDH Logistic regression Lymphocyte count median age medical records Mild multivariable analysis Odds ratio Patient patients performed proportion random risk risk factor Risk factors SAA serum amyloid severe COVID-19 severe disease course significantly higher single hospital statistically student suggested the mean Treatment unique variable Wuhan, China [DOI] 10.1038/s41598-021-82810-3 PMC 바로가기 [Article Type] Article
Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patientsCOVID-19 환자의 SARS-CoV-2 특이 항체의 혈청 수준에 대한 비만의 영향Research Article Published on 2021-03-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 바이오마커, 진단, [키워드] (C-reactive protein) (nonesterified fatty acids) acute respiratory syndrome amyloid A antibody Blood BMI Body body mass body mass index C-reactive protein chronic systemic inflammation condition Corona coronavirus coronavirus disease COVID-19 COVID-19 obese patient COVID-19 obese patients COVID-19 patient COVID-19 patients CRP evaluated exacerbated expected ferritin help Humoral immunity Hypothesis identify IgG antibodies immune dysfunction Immunity IMPROVE index individual inflammaging Inflammatory inflammatory conditions inflammatory markers Inflammatory response influence marker mass NEFA nonesterified fatty acids obese obese patients obesity Predictive Predictive value pro-inflammatory Protein pulmonary inflammation reduced respiratory Result risk SAA SARS-CoV-2 SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG secretion serum amyloid serum amyloid A protein Serum level serum levels Severe Acute Respiratory Syndrome Corona Virus Severe acute respiratory syndrome corona virus-2 shown specific IgG antibodies systemic inflammation [DOI] 10.1371/journal.pone.0245424 PMC 바로가기 [Article Type] Research Article
A retrospective study of clinical and laboratory features and treatment on cats highly suspected of feline infectious peritonitis in Wuhan, ChinaArticle Published on 2021-03-042022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] age Characteristics clinical manifestation Clinical signs clinically clinician correlated cured diagnosing diagnostic diagnostic value effusion fatal disease Feline infectious peritonitis GS-441524 highlight immunohistochemistry Increased Infectious-disease diagnostics laboratory abnormality laboratory feature lymphopenia male mortality rate onset of disease physical Retrospective study SAA serum amyloid significantly submitted treated Treatment viral disease Wuhan, China Zoology [DOI] 10.1038/s41598-021-84754-0 PMC 바로가기 [Article Type] Article
Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control studyResearch Article Published on 2021-02-242022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, [키워드] 2019-nCoV age C-reactive protein (CRP case control study change changes in Characteristics Chest CT China clinical Clinical characteristics clinical information coronavirus disease Coronavirus disease-19 cough Course COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient CRP defined disease severity elevated evaluate exhibited fatigue feature Features Fever human-to-human transmission infected patient Infection Mild mild in severity mild infection moderate morphology MOST Most patient no difference no statistical difference occurred outbreak oxygenation index oxyhemoglobin parameter Patient patients with COVID-19 Result SAA serum amyloid Severe case severe disease severity of COVID-19 Severity of infection Sex statistically significant difference Travel two group Wuhan [DOI] 10.1186/s12879-021-05897-z PMC 바로가기 [Article Type] Research Article
Circulating Exosomes Are Strongly Involved in SARS-CoV-2 InfectionMolecular Biosciences Published on 2021-02-222022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Activation addition Analysis approach AUC Biomarker Biomarkers C1r circulating Coagulation complement complement pathways component Course COVID-19 pathogenesis diagnostic Disease progression disease severity Exosome extracellular vesicle fibrinogen Host host cell host response host-response immune response Infection Inflammation investigated involved main mechanism modulate novel coronavirus SARS-CoV-2 organ dysfunctions plasma plasma exosomes presenting proteomic proteomics SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA serum amyloid shown Spread Therapeutic strategies tissue damage viral infection virus [DOI] 10.3389/fmolb.2021.632290 PMC 바로가기 [Article Type] Molecular Biosciences
Serum Amyloid A in Inflammatory Rheumatic Diseases: A Compendious Review of a Renowned Biomarker염증성 류마티스 질환의 혈청 아밀로이드 A: 저명한 바이오마커에 대한 포괄적인 검토Review Published on 2021-02-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] Activation acute phase amyloid A amyloidosis arising Arthritis autoinflammatory disease biological therapy Biomarker Biomarkers C-reactive protein C-reactive protein (CRP cascade clinical Clinical practice Clinical use clinical utility collected coronavirus disease Coronavirus disease 2019 COVID-19 database Disease activity disease severity erythrocyte sedimentation erythrocyte sedimentation rate ESR evaluated immune system Immunotherapy Inflammasome Inflammation Inflammatory interleukin interleukin 17 isoform lead management markers of inflammation mechanism Pathogenesis Patient patients producing Protein proteomic recent finding recruitment review rheumatic disease Rheumatic diseases rheumatic inflammatory disease rheumatoid arthritis SAA secondary amyloidosis sedimentation rate serum amyloid serum amyloid A severe coronavirus disease shown T helper cells target therapeutic strategy utility [DOI] 10.3389/fimmu.2020.631299 PMC 바로가기 [Article Type] Review
COVID-19 patients with hypertension are at potential risk of worsened organ injuryArticle Published on 2021-02-122022-10-04 Journal: Scientific Reports [Category] MERS, 바이오마커, 임상, [키워드] analyzed C-reactive protein cardiovascular disease chronic disease Chronic illness Cohort COVID-19 COVID-19 patient COVID-19 patients death described Deterioration diabete diagnosed with COVID-19 disease Disease progression dry cough dynamic enrolled epidemiological Epidemiology exhibited fatigue Health Hospital admission hypertension hypertensive patient illness onset increased risk indicated inflammatory reactions Laboratory less Lymphocyte count median age median time men neutrophil counts NT-proBNP observation organ injury outcome Patient patients positive RT-PCR potential risk radiological Retrospective study serum amyloid severe disease Spread Symptom viral infection with COVID-19 women worsened [DOI] 10.1038/s41598-021-83295-w PMC 바로가기 [Article Type] Article