Phase II/III trial of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy in severe COVID-19 patients: study protocol for a randomized controlled trialArticle Published on 2022-11-082022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] adaptive anti-COVID-19 IVIG antivirals clinical evidence clinical trial collected convalescent convalescent plasma COVID-19 cumulative death Efficacy eligibility criteria evaluate Health hyperimmune immunization immunomodulators intravenous Intravenous immunoglobulin low dose monoclonal antibodies Neutralizing non-specific novel Novel coronavirus outcome Passive passive immunization Patient phase Pneumonia polyclonal polyclonal antibodies Pooled convalescent plasma Potential treatment Randomized Randomized controlled trial receive Recovered COVID-19 patients reported SARS CoV-2 SARS CoV-2. SARS-CoV-2 sealed Secondary outcomes severe COVID-19 severe COVID-19 patient severe COVID-19 patients Standard of care Steroids Study protocol therapeutic option therapy treat Treatment Trial variant variants of concern virus virus particles World Health Organization [DOI] 10.1186/s13063-022-06860-2 PMC 바로가기
Intestinal Infarction in COVID-19 Pandemic: A Case SeriesOriginal Article Published on 2022-11-072022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] Abdominal CT Scan blood flow Clinical data coagulation disorder collected Complication coronavirus coronavirus disease COVID-19 described digestive system disrupt events Evidence headache Health Imam include Infection infection process intestinal Iran Ischemia Mashhad Medical Sciences mesenteric ischemia Necrosis novel operative organs pathological finding Patient patients hospitalized physician reported respiratory symptoms Reza risk factor Sery severe COVID-19 Severe COVID-19 Infection Severe COVID-19 pneumonia Spread suggested Symptom thrombosis university Vascular visceral with COVID-19 [DOI] 10.30699/IJP.2021.525280.2600 PMC 바로가기 [Article Type] Original Article
Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell deathArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] acid Alter alteration Biomarker caused cell death change circulating Cohort contribute COVID-19 COVID-19 patient disease dysfunction Europe exclusion FABP2 functional Gut immune include increase in Infection Inflammation Inflammatory responses inhibited marker median metabolites microbial product Mild moderate NMR outliers pathology Patient patients with moderate plasma Plasma marker positive correlation reduced reduction in route of infection SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severe group Severity of disease shown systemic [DOI] 10.1038/s41598-022-23282-x PMC 바로가기
High vaccine effectiveness against severe COVID-19 in the elderly in Finland before and after the emergence of OmicronArticle Published on 2022-11-052022-11-16 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] 95% CI Admission caused Cohort cohort analysis COVID-19 COVID-19 hospitalization COVID-19 vaccines dose doses Effectiveness elderly Elderly cohort evaluated Follow-up hazard ratio Heterologous homologous Hospitalization ICU ICU treatment Immunity individuals intensive care omicron outcome protection reduced remained restored SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Omicron variant severe COVID-19 vaccination Vaccine waned Waning vaccine effectiveness. [DOI] 10.1186/s12879-022-07814-4 PMC 바로가기
Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severityReview article Published on 2022-11-012022-10-05 Journal: Gene [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE1 ACE2 AGTR1 ApoE association Case-control CCR5 Clinical outcome contribute contributing to Control correlation country COVID-19 COVID-19 pandemic COVID-19 susceptibility Critical eligible Evidence exacerbated examined Factor Genes Genetic genetic determinant Genetic polymorphism Genetic variant greater Health Healthcare system Host host genetics human gene I/D identify IFITM3 implicated increased risk increasingly infected individual infected individuals Infection investigated magnitude manifestation Manifestations Meta-analysis meta-analysis mutations Patient performed polymorphism progression provide required Research rs2285666 SARS-CoV-2 severe COVID-19 severity Statistical power statistically significant susceptibility systematic review variant with COVID-19 [DOI] 10.1016/j.gene.2022.146790 [Article Type] Review article
TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, ThailandArticle Published on 2022-11-012022-11-16 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome cause contribute coronavirus coronavirus disease COVID-19 COVID-19 severity cytokine expression heterozygous immune responses Mutation Nonsense Patient produced respiratory infections resulting SARS SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severe COVID-19 T cell T cells Thailand TIGIT variant viruses zoonoses zoonoses. [DOI] 10.3201/eid2811.220914 PMC 바로가기
COVID-19 vaccine effectiveness against hospitalization due to SARS-CoV-2: A test-negative design study based on Severe Acute Respiratory Infection (SARI) sentinel surveillance in SpainArticle Published on 2022-11-012022-11-16 Journal: Influenza and Other Respiratory Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Acute respiratory infection Admission age ARI Characteristics circulation COVID-19 COVID-19 hospitalization COVID-19 vaccine decrease Delta Effectiveness epidemiological estimate Evidence hospital Hospitalization hospitals Influenza mRNA vaccine mRNA vaccines no difference Older primary care respiratory SARI surveillance SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 Spain Spanish Surveillance surveillance network System test-negative design vaccination Vaccine vaccine effectiveness. [DOI] 10.1111/irv.13026 PMC 바로가기
Mid-term pulmonary sequelae after hospitalisation for COVID-19: The French SISCOVID cohortResearch article Published on 2022-11-012022-10-05 Journal: Respiratory medicine and research [Category] 임상, [키워드] age Chest computed tomography clinical examination Clinical features Cohort complications consequence COVID-19 CT-scan described diffusing discharge Dyspnoea evaluated Follow-up French functional hospital discharge hospitalisation hospitalised ICU impairment Improved independent risk factor intensive care Invasive mechanical ventilation lung lung capacity Lung function mMRC multicentre nasal non-invasive ventilation observational study outcome Pathogenesis Patient Patient discharge Pneumonia Pulmonary function tests radiological Result sequelae severe COVID-19 significantly more therapeutic option ventilatory [DOI] 10.1016/j.resmer.2022.100933 [Article Type] Research article
Immunogenicity and efficacy of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysisArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] affected Antibody titer booster vaccination both groups Cochrane Library comparable COVID-19 COVID-19 vaccine COVID-19 vaccines effective Efficacy healthy controls healthy individuals HIV immunogenicity IMPROVE in healthy individuals inclusion criteria increased risk less Messenger RNA Meta-analysis participant patients PLWH random-effect reduced risk ratio SARS-CoV-2 SARS-CoV-2 antibody searched second dose Seroconversion severe COVID-19 significantly subject systematic review vaccination. vaccine dose was performed with HIV [DOI] 10.1016/j.ijid.2022.10.005 PMC 바로가기
Cardiac megakaryocytes in SARS-CoV-2-positive autopsiesArticle Published on 2022-11-012022-11-15 Journal: Histopathology [Category] SARS, 치료기술, [키워드] addition Autopsies Autopsy average cardiac Cell Cohort Comorbidity correlated Course COVID-19 COVID-19 cohort evaluated groups Increasing Infection inflammatory markers Inflammatory response Laboratory management megakaryocytes nonspecific parameter Patient performed Platelet Platelets platelets. precursor pulmonary disease Pulmonary emboli reported Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2-positive patient selected severe COVID-19 significantly higher statistically significant supported the disease thromboembolic thrombotic complication viral infections were assessed [DOI] 10.1111/his.14734 PMC 바로가기