Prognostic value of heparin-binding protein for mortality in severe COVID-19 pneumoniaArticle Published on 2022-09-012022-11-15 Journal: Biomarkers in Medicine [Category] 바이오마커, [키워드] analyzed Biomarkers control group COVID-19 cutoff value defined Diagnosis died emergency medicine group healthy control Heparin-binding protein Infection Inflammation investigated Mortality Patient patients with COVID-19 Pneumonia Prognosis Protein sensitivity serious COVID-19 Severe COVID-19 pneumonia significantly higher specificity statistically statistically significant survived the patient [DOI] 10.2217/bmm-2022-0265 PMC 바로가기
DOCK2 is involved in the host genetics and biology of severe COVID-19 Research Published on 2022-08-082022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, [키워드] age Analysis Biomarker characterized chromosome Cohort collected conducted controls COVID-19 decreased expression DOCK2 downregulation dysregulated East Asian Europeans expression Factor Genetic Genome-wide association study GWAS highlighting Host host genetics Host immune response identifying individual individuals initial involved Japanese less lung Macrophage Non-classical monocytes oedema pandemic Patient Peripheral blood Pneumonia populations prevalent recruitment responses risk allele RNA-sequencing SARS-COV-2 infection Severe case severe COVID-19 Severe COVID-19 pneumonia severity specimen suppressed therapeutic target type I interferon variant viral loads weight loss younger patients [DOI] 10.1038/s41586-022-05163-5 [Article Type] Research
Therapeutic anticoagulation using heparin in early phase severe coronavirus disease 2019: A retrospective studyObservational Study Published on 2022-08-012022-10-05 Journal: The American journal of emergency medicine [Category] 임상, [키워드] administration adverse event Anticoagulant anticoagulation association Care Characteristics Coronavirus disease 2019 COVID-19 Critical care disease early administration early phase ECMO Effect extracorporeal membrane oxygenation group groups heparin hospital ICU in-hospital mortality in-hospital mortality rate intensive care intensive care unit Japan mechanical ventilation multivariate model outcome Oxygen therapy Patient Pneumonia retrospective Retrospective study secondary outcome severe coronavirus disease severe COVID-19 patient Severe COVID-19 pneumonia significantly significantly lower systemic anticoagulation therapeutic therapeutic anticoagulation therapy unfractionated heparin ventilator-free day VFD [DOI] 10.1016/j.ajem.2022.05.031 PMC 바로가기 [Article Type] Observational Study
Incidence and Clinical Features of Pneumomediastinum and Pneumothorax in COVID-19 PneumoniaObservational Study Published on 2022-08-012022-10-05 Journal: Journal of Intensive Care Medicine [Category] 임상, [키워드] affected air leak Case series Chest clinical Complication complication of COVID-19 COVID-19 CPAP CRP death described Deterioration develop Evidence Features greater IMV incidence increase in lower risk median NHS occurred outcome Patient patients with COVID-19 Pneumomediastinum Pneumonia Pneumothorax positive pressure ventilation Respiratory Support retrospective risk risk factor severe COVID-19 disease Severe COVID-19 pneumonia severe disease thought Trust vaccination West zone [DOI] 10.1177/08850666221091441 PMC 바로가기 [Article Type] Observational Study
High-flow nasal oxygen in severe COVID-19 pneumonia and tocilizumab중증 COVID-19 폐렴 및 토실리주맙에서의 고유량 비강 산소Comment Published on 2022-08-012022-09-12 Journal: Infectious diseases now [Category] 진단, [키워드] Abstract COVID-19 COVID-19 pneumonia High-flow nasal oxygen nasal nasal oxygen Severe COVID-19 pneumonia Tocilizumab [DOI] 10.1016/j.idnow.2022.04.008 PMC 바로가기 [Article Type] Comment
Rotational thromboelastometry in patients with type 2 diabetes and mild COVID-19 pneumonia: A pilot prospective studyObservational Study Published on 2022-07-012022-10-05 Journal: Medicine [Category] 임상, [키워드] Blood donors blood sample changes in complex consecutive patient control group COVID-19 demonstrated diabete Diabetic enrolled healthy healthy donors Hemostasis higher risk Mild no significant difference not affected parameter Patient performed Pneumonia Prospective Study reagents Severe COVID-19 pneumonia significant difference T2D tested thromboembolic complications type 2 diabete Whole blood [DOI] 10.1097/MD.0000000000029738 PMC 바로가기 [Article Type] Observational Study
Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trialRandomized Controlled Trial Published on 2022-07-012022-10-04 Journal: Intensive care medicine [Category] COVID19(2023년), SARS, 임상, [키워드] active smoker Acute respiratory failure Administered Adverse affected artificial assessment assigned Care conducted confidence interval coronavirus disease COVID-19 Critically ill patient daily dose days alive dose double-blind Efficacy and safety event France function intensive care unit intensive care units Invasive mechanical ventilation IQR mechanical ventilation median men Mortality multicentre Nicotine Nicotinic receptor not differ Odds ratio on mechanical ventilation Organ failure Patient Placebo placebo-controlled placebo-controlled trial Pneumonia Primary outcome Randomized randomized trial Randomly receive receiving reduce renal replacement therapy secondary outcome Severe COVID-19 pneumonia significantly smoker stratified symptomatic patient the median the placebo group Trial two group two groups vasopressor support Ventilation ventilator-free day with COVID-19 [DOI] 10.1007/s00134-022-06721-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
A pilot phase Ib/II study of whole-lung low dose radiation therapy (LDRT) for the treatment of severe COVID-19 pneumonia: First experience from AfricaClinical Trial Published on 2022-07-012022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] 24 hour absence benefit cellular proliferation clinical benefit clinical trial Complete condition conducted COVID-19 CRP Cytokine storm D-dimer Day death defined demonstrated died discharge discharged dose Efficacy elevated enrolled feasibility feasible fraction High-resolution HRCT identify Inflammatory marker inhibit investigator-initiated Kenya low dose lung management mechanical ventilation median time on mechanical ventilation oxygen Oxygen requirement Oxygenation Patient patients PCR Pneumonia polymerase chain primary endpoint progressed radiation therapy remained resources SAE Safe secondary endpoint Sepsis severe COVID-19 Severe COVID-19 pneumonia the patient therapy Toxicity treat treated Treatment Trial university Vaccine were excluded [DOI] 10.1371/journal.pone.0270594 PMC 바로가기 [Article Type] Clinical Trial
Tocilizumab therapy in SARS-CoV-2 pneumonia: A matched retrospective cohort analysisSARS-CoV-2 폐렴에서 토실리주맙 요법: 일치된 후향적 코호트 분석Case Reports Published on 2022-06-242022-09-12 Journal: Medicina clínica [Category] COVID19(2023년), SARS, 진단, [키워드] age all-cause mortality Analysis baseline benefit C-reactive protein Clinical improvement Clinical practice Cohort cohort analysis Comorbidities consecutive patient coronavirus disease COVID-19 death decrease English Estudio de cohortes pareadas Evolución group hospital discharge immunomodulatory therapy intravenous tocilizumab Invasive mechanical ventilation Matched Matched cohort study no significant difference outcome Patient rapid normalization receiving retrospective retrospective cohort SARS-CoV-2 severe COVID-19 Severe COVID-19 pneumonia SOC Spanish Standard of care symptoms onset TCZ therapy Tocilizumab Tratamiento inmunomodulador. treated [DOI] 10.1016/j.medcli.2021.06.014 PMC 바로가기 [Article Type] Case Reports
Impaired Kallikrein-Kinin System in COVID-19 Patients’ SeverityObservational Study Published on 2022-06-222022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] Accuracy ACE2 Admission analyzed Bradykinin (BK) C1 esterase inhibitor cascade characterized clinical laboratory Coagulation Combination Concentration consecutive patient control group COVID-19 CPN1 cutoff value D-dimer D-dimer level disease disease severity dysregulated dysregulation enzyme Factor healthy subject ICU ICU admission Impaired independent independent predictor Inflammation intensive care involved Kallikrein-kinin system KLKB1 lymphopenia multivariate multivariate logistic regression multivariate model NLRP3 NLRP3 inflammasome Observational cohort study Odds ratio pathophysiology patients with COVID-19 peptide plasma concentration plasma protein Protein reported retained Severe COVID-19 pneumonia severity subunit System Thromboinflammation vascular homeostasis was related [DOI] 10.3389/fimmu.2022.909342 PMC 바로가기 [Article Type] Observational Study