Heterologous adenovirus-vector/messenger RNA regimen is associated with improved severe acute respiratory syndrome coronavirus 2 humoral response in liver transplant recipientsArticle Published on 2022-10-012022-11-15 Journal: Hepatology communications [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Analysis analyzed Anti-spike anti-Spike IgG Antibody Response AstraZeneca BBIBP-CorV BMI booster response ChAdOx1 Clinical data collected Combination Concentration Control coronavirus correlation different dose dose evaluate evaluated Future groups healthy volunteer Heterologous homologous humoral IgG immunized Immunoglobulin inactivated information liver LTR LTRs Messenger RNA MMF neutralizing antibody nucleocapsid protein Odds ratio positive positive serology Probability prospective cohort study R 2 receiving recipient reduced reduction regimen reported RNA SARS-CoV-2 SARS-CoV-2 anti-spike IgG Serious Adverse Event Side effects significant difference significantly significantly higher Sinopharm Vaccine vaccine dose vaccine platform [DOI] 10.1002/hep4.2034 PMC 바로가기
Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19Research article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory distress Affect Algorithm Analysis antiviral therapy Brain causes clinical study Col1a1 collagen Comorbidities Complication complications component Control coronavirus COVID-19 COVID-19 patients develop diagnostic drug drug repositioning FDA approved drug Genetic help immune system independent Infection Inflammation Inflammatory response Influenza involved kidneys Lungs machine learning methodology offer other organ pathway Pathways Patient performed principal Regulation response responsible Result reveal RSV SARS-CoV-2 SARS-COV-2 infection severity Side effect Side effects Small scale genetic signature susceptibility syndrome the disease the interferon Transcriptome transcriptomic transcriptomic analysis transcriptomic data virus replication [DOI] 10.1016/j.compbiomed.2022.106029 [Article Type] Research article
Patient preferences and current practice for adults with steroid-resistant ulcerative colitis: POPSTER mixed-methods studyArticle Published on 2022-10-012022-11-15 Journal: Health technology assessment (Winchester, England) [Category] 진단, [키워드] administration assessment carried Characteristics Consensus COVID-19 pandemic drug duration of symptom Effectiveness evaluate experiment experiments Factor Future greater Health personnel health-care highlight IMPROVE Inflammatory bowel disease influence information journal lack less library Necrosis NHS NIHR offered over Patient Patient preference patients per day predicted Prednisolone preference preferences Probability professional professionals qualitative research randomised controlled trial Randomised controlled trials recommendation Research respond risk sample sizes secondary care Selection bias severity Side effect Side effects subject surveys and questionnaires Symptoms technology therapeutic benefits Tofacitinib Treatment ulcerative ulcerative colitis ulcerative colitis. undergo website [DOI] 10.3310/RHXR5192 PMC 바로가기
Multiple sclerosis relapse after COVID-19 vaccination: A case report-based systematic reviewReview article Published on 2022-10-012022-10-05 Journal: Journal of clinical neuroscience : official journa [Category] 진단, [키워드] Abstract benefit booster dose Case report case sery concern COVID-19 COVID-19 vaccination COVID-19 vaccine disease dosage Efficacy eligible Exacerbation FIVE include Infection Multiple multiple sclerosis Patient patients Relapse reported Result risk searched second dose Side effects stimulate Symptom systematic review vaccination vaccination against COVID-19 Vaccine weakness Web of Science [DOI] 10.1016/j.jocn.2022.08.012 [Article Type] Review article
Neuroinflammation in Dementia-Therapeutic Directions in a COVID-19 Pandemic SettingArticle Published on 2022-09-222022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] activate Activation Affect cognitive complications Concentration COVID-19 cytokine production Dementia direction dysfunction Efficacy Factors Glia glial cell glial cells group of diseases heterogenous highlight human organism IL-1β immune response Inconclusive Inflammation Inflammatory Intervention molecular neurodegenerative Neuroinflammation Neuroinflammation. Neuron NSAID outcome pathology peripheral pro-inflammatory signaling provide resulting risk SARS-CoV-2 setting shown Side effects therapeutic approaches TNF TNF antagonist TNF antagonists while [DOI] 10.3390/cells11192959 PMC 바로가기
Antibody titers among healthcare workers for coronavirus disease 2019 at 6 months after BNT162b2 vaccinationArticle Published on 2022-09-162022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] acute respiratory syndrome age Analysis analyzed Anti-spike antibody antibody level Antibody titre BNT162b2 BNT162b2 vaccine Care conducted coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 decrease dose Factor female females healthcare healthcare worker Healthcare workers hospital IgG IgG antibody Japanese negative correlation participant Participants preserved Prospective Study Protein Regression SARS-CoV-2 side Side effects tested the vaccine vaccination vaccination. were infected [DOI] 10.1016/j.vaccine.2022.08.035 PMC 바로가기
Transcriptomics, Cheminformatics, and Systems Pharmacology Strategies Unveil the Potential Bioactives to Combat COVID-19Article Published on 2022-09-132022-11-16 Journal: Molecules [Category] SARS, 유전자 메커니즘, [키워드] addition analysis analyzed approach caused Cheminformatics co-expression combat Complete COVID-19 determine disease drug candidate Efficiency Features functional Genetic higher efficiency identify immune immune gene Infection Laboratory lack mechanism molecular molecular docking molecular docking analysis Mutation pathway enrichment pharmacological Pharmacology Phytocompounds plant plants Potential Prevalence Regulation required SARS-CoV-2 selected Side effects Signaling Strategy System systems pharmacology. the SARS-CoV-2 virus therapeutic these compound transcriptomics transmission rate treat unique unique genes Vaccinations viral disease [DOI] 10.3390/molecules27185955 PMC 바로가기
Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2′-O-ribose methyltransferasesArticle Published on 2022-09-012022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 치료제, [키워드] AHCY Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral drug antivirals attenuation Concomitant COVID-19 COVID-19 treatments Drug screening DZNep enzyme Ex vivo exhibit functional Host host-directed hyperinflammation identify Immune escape immunomodulatory effect in silico in vitro in vivo independent Infection Inflammation inhibitor Interaction Lung fibrosis marker Methylation methyltransferase methyltransferase. pathogen reduce SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Side effects Stage suppresse Treatment Viral RNA virus replication [DOI] 10.15252/embj.2022111608 PMC 바로가기
Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine in people living with HIV: A cross-sectional studyHIV 보균자에서 비활성화된 SARS-CoV-2 백신의 면역원성과 안전성: 단면 연구Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis antibody Antiretroviral therapy appear ART CD4+ T cell CD4+ T cells CD4+ T-cell chemiluminescence Chinese control group COVID-19 COVID-19 vaccine cross-sectional delta variant Delta variants detect Efficacy and safety enzyme enzyme immunoassay healthy individual Human immunodeficiency virus IgG IgM antibodies IgM antibody immunoassay immunodeficiency immunogenicity inactivated indicated individual Mild multivariable analysis NAb Neutralizing neutralizing antibody Odds ratio PLWH proportion Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific IgG self-limiting seropositive Seropositivity serum IgG serum levels Side effect Side effects side effects. significantly higher T cells titers vaccination was used wild-type SARS-CoV-2 with HIV [DOI] 10.1002/jmv.27872 PMC 바로가기 [Article Type] Article
Current status of antihistamine drugs repurposing for infectious diseasesReview article Published on 2022-09-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, [키워드] active against Anti-infective Antihistamines applicability article Blood brain barrier Candida carried Chemical library clinical trial clinical trials cross current determine dose drug Ebola virus Efficacy English eventual need FIVE Google Scholar Government groups growth Health hepatitis C IC50 identify in vitro activity in vitro data in vivo Infectious disease information inhibited intrinsically lack Leishmania objective off-label Pathogens pharmacological Plasmodium repurposing Research Result rodents Side effects Staphylococcus aureus Staphylococcus epidermidis Support suppressed Trial Trypanosoma virus [DOI] 10.1016/j.medidd.2022.100140 [Article Type] Review article