Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, BrazilArticle Published on 2022-10-212022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] addition affected age Brazil caused concern COVID-19 COVID-19 case COVID-19 cases death deaths disease epidemiological fluctuation Gamma Gender genetic variants Host Impact individual men nasopharynx P.1 pandemic Patient replaced replacement SARS-CoV-2 SARS-CoV-2 lineage significant increase study period symptomatic the patient the SARS-CoV-2 variant variant of concern Viral load VoC [DOI] 10.3390/v14102314 PMC 바로가기
Immune Response after the Fourth Dose of SARS-CoV-2 mRNA Vaccine Compared to Natural Infection in Three Doses’ Vaccinated Solid Organ Transplant RecipientsArticle Published on 2022-10-192022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration analyzed booster booster dose booster doses Breakthrough infection cellular response CLIA Cohort COVID-19 dose Efficacy ELISA ELISpot assay fourth dose General population humoral IgA IgA level IgG immune immune response IMPROVE in both group Infection mRNA mRNA vaccine natural natural infection new SARS-CoV-2 no difference Organ transplant Patient positive recipient recipients repeated response SARS-CoV-2 SARS-COV-2 infection secretion serum IgG severe COVID-19 significant increase significantly increased Solid solid organ transplant Solid organ transplant recipients Still T cell T-cell T-cell Response Transplant vaccination Vaccine vaccine-induced immune response variants of concern [DOI] 10.3390/v14102299 PMC 바로가기
Non-steroidal anti-inflammatory drugs and clinical outcomes in patients with COVID-19Article Published on 2022-10-172022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] meta-analysis, [키워드] 28-day mortality Analysis analyzed Anti-inflammatory anti-inflammatory drug benefit Clinical outcome clinical outcomes clinical status coronavirus disease COVID-19 COVID-19 pandemic decrease discharge Evidence hazard ratio hospital discharge Hospitalized hospitalized patient In-hospital medication Meta-analysis Mortality non-steroidal anti-inflammatory drug Nonsteroidal anti-inflammatory drugs NSAID NSAIDS outcome Patient patients with COVID-19 performed post-hoc question raised receive risk Safe severe COVID-19 severity significant increase survival Treatment Trial two group with COVID-19 [DOI] 10.3389/fcimb.2022.935280 PMC 바로가기
Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 studyArticle Published on 2022-10-102022-11-15 Journal: Respiratory Research [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute phase addition affected Analysis biological marker CD3+ cells CD4 CD8 Cell cell population central memory Central memory T cells control group control patient controls COVID-19 COVID-19 diagnosis cross-sectional decrease described differential expression disease early phase effector effector memory Effector memory T cells flow cytometry group homeostasis hospital Hospital admission immune increase interstitial interstitial lung involvement interstitial pneumonia lymphocyte subpopulation Lymphocyte subpopulations memory memory T memory T cells Patient patients with pneumonia performed Peripheral blood peripheral lymphocyte Pneumonia positive pre-existing T-cell protocol reactivity recruited Research Respiratory disease SARS-CoV-2 SARS-CoV-2 PCR severe COVID-19 patients significant decrease significant increase study participant study period subpopulations subset T cell T-cell therapeutic viral respiratory infections were assessed [DOI] 10.1186/s12931-022-02190-8 PMC 바로가기
MIS-C: A COVID-19-as sociated condition between hypoimmunity and hyperimmunityArticle Published on 2022-10-032022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] activated Activation acute phase Admission Analysis ATM Autoimmune Autoimmune disease Autoimmune diseases autoimmune pathogenesis autoinflammatory disease Autoinflammatory diseases B cell cellular Characteristics children clearance complication of COVID-19 contribute Critical cytokine response Cytokine storm Cytokines Cytometry demonstrated develop diagnostic biomarker DOCK8 event FCN3 Flow flow cytometry Genetic Genetic variant healthy control help heterogeneity Hospital admission identified variant IFN IFN-α IFN-β IFN-γ IFNγ IL-10 IL-12p70 IL-17A IL-6 immune dysregulation immunodeficiency immunological induce Inflammatory inflammatory pathway involved knowledge lymphocyte lymphopenia management MCM4 MIS-C MOST multisystemic mutated NCF1 NGS NOD2 organ Pathogenesis pathway Patient patients Population PRF1 reduction serum serum cytokine significant increase syndrome Th1 the disease therapeutic Therapies tissue damage TNF Type variant was increased [DOI] 10.3389/fimmu.2022.985433 PMC 바로가기
A SARS-CoV-2 oral vaccine development strategy based on the attenuated Salmonella type III secretion systemArticle Published on 2022-10-012022-11-15 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] administration Analysis antibody Antigen antigens attenuated Salmonella ΔhtrA-VNP Bacterial caused CD44 CD69 COVID-19 vaccine cytometric cytosol delivery effective element elicited Express expression Flow fluorescence microscopy Heterologous IgA IgG in vitro increase in Macrophage mixed bacterial preparations. mutant N-protein NTD Oral vaccine pathogenicity phenotype Plasmid promoter RBD S-protein Safe Salmonella SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine screened secrete secretion shown Significance Significant significant increase SPI-2 strain T-cell activation T3SS the vaccine type III Vaccine was used [DOI] 10.1111/jam.15720 PMC 바로가기
Redox imbalance in COVID-19 pathophysiologyArticle Published on 2022-10-012022-11-16 Journal: Redox Biology [Category] 치료기술, [키워드] alteration Analysis antioxidant Ascorbate association biochemical assay Blood circulating Clinical outcome contributing to control subject COVID COVID-19 COVID-19 infection Diagnosis electron Electron paramagnetic resonance enrichment analysis enrolled EPR evaluate greater ICAM-1 ICU indicated Inflammation Inflammatory intensive care marker Mortality mRNA Multiplex assay multivariate non-ICU non-specific Oxidant oxidative stress parameter pathophysiologic pathophysiology pathway performed Peripheral blood positive predict predicted quantified redox Redox imbalance reducing reduction in repetition required SARS-CoV-2 Sequencing serum Serum level significant increase subject subjects therapeutic strategy Topic transcriptomics TSLP uric acid Vascular VCAM-1 Virus Disease was performed [DOI] 10.1016/j.redox.2022.102465 PMC 바로가기
Induction of Hypoxic Response in Caco-2 Cells Promote the Expression of Genes Involved in SARS-CoV-2 Endocytosis and TranscytosisArticle Published on 2022-10-012022-11-16 Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 analyzed Caco-2 Caco-2 cell downregulation elevated endocytosis expression expression level expression of gene hypoxia hypoxic include increase in induction intestine involved LDL LDLR low-density LRP1 LRP4 LRP5 manuscript mechanism miRNA mRNA oxyquinoline receptor response RNA sequencing SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 viral particles significant increase TFRC Transcriptome transcytosis Transport treated upregulation [DOI] 10.1134/S1607672922050118 PMC 바로가기
Performance assessment and improvement of a care unit for COVID-19 patients with resilience engineering and motivational factors: An artificial neural network methodResearch article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] 변종, [키워드] Algorithm Analysis Artificial neural network asked Care Combination Complete COVID-19 COVID-19 patient Data envelopment analysis detrimental disease evaluate healthcare providers Healthcare system hospital Hospital staff IMPROVE indicated investigated Job satisfaction motivational factor New coronavirus performance Performance evaluation performed physical questionnaire required Resilience Resilience engineering sensitivity analysis significant increase statistical statistical test Threats was determined [DOI] 10.1016/j.compbiomed.2022.106025 [Article Type] Research article
Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Biochimie [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Admission association Biomarker circulating Comorbidities Course COVID-19 COVID-19 patient COVID-19 patients D-dimer Diabetes Mellitus disease disease severity early phase effective ELISA healthy controls host receptor hypertension increase in Infection investigated involved marker membrane moderate outcome plasma Plasma level positive correlation sACE2 SARS-CoV-2 Severe case shown significant increase soluble ACE2 the SARS-CoV-2 was determined was obtained was performed [DOI] 10.1016/j.biochi.2022.06.005 PMC 바로가기