An integrated understanding of the evolutionary and structural features of the SARS-CoV-2 spike receptor binding domain (RBD)Article Published on 2022-09-302022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis binding Clustering co-evolution Computational drug conformational flexibility Conventional COVID-19 Critical deep Deep mutation scan develop drug-target druggability Effect Evolution expected exploratory feature Fuzzy C-means clustering highlight impair Interaction machine machine learning molecular dynamic simulation Molecular simulation Mutation network analysis Protein Quantitative RBD Receptor binding domain Region SARS-CoV-2 sequence Sequence space analysis small molecule stability Structure Structure network analysis. the RBD the SARS-CoV-2 turn [DOI] 10.1016/j.ijbiomac.2022.07.022 PMC 바로가기
The regulation of ISG20 expression on SARS-CoV-2 infection in cancer patients and healthy individualsArticle Published on 2022-09-132022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] analyzed anti-SARS-CoV-2 anticancer Bone marrow Cancer cancer cell cancer cell lines cancer patient Cancer patients chemokine combating cordycepin cordycepin (CD). correlated COVID-19 COVID-19 pandemic domain exhibited expression functional healthy healthy individual highest immune Immune cell infiltration immune infiltration individuals information inhibit Invasion ISG20 ISG20 expression isoform less Lymphocytes lymphoid tissues marker Methylation MHC molecule mRNA expression mutant N6 N6-dimethyladenosine (m 6 2A) outcome overexpression promoter receptors Regulation SARS-CoV-2 SARS-COV-2 infection significantly significantly increased significantly lower small molecule survival survival rate susceptibility the median therapeutic potential tissue tissues traditional Chinese medicines treat tumorigenesis underlie virus were used [DOI] 10.3389/fimmu.2022.958898 PMC 바로가기
A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodiesArticle Published on 2022-09-122022-11-15 Journal: Journal of Biomedical Science [Category] SARS, 변종, 신약개발, 치료제, [키워드] abrogated acute respiratory syndrome addition Analysis antibodies antibody Antiviral antiviral drugs authorization BNT162b2 clinical benefits Clinical data clinical trial coronavirus COVID-19 Critical diagnostic distribution drug drugs Effect Effectiveness Efficacy effort Emergency global public health help Infection mRNA vaccines mRNA-1273 mutant strain Mutation Neutralizing antibodies neutralizing antibody neutralizing effect novel coronavirus disease omicron overcome pandemic presenting problems Regulatory SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant Scientific community shown small molecule Small molecule antiviral drugs small molecule drugs Support the spike protein therapeutic Therapeutics Treatment utility Vaccine Vaccine development Vaccines variant variants widespread [DOI] 10.1186/s12929-022-00852-9 PMC 바로가기
Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization ApproachArticle Published on 2022-09-122022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] agent antiviral property approach computational studies conjugate Conjugates cytotoxicity healthcare hybridization indole investigated molecular Molecular modeling Potential quinoline rhodanine. SAR-CoV-2 SARS-CoV-2 small molecule synthesis virus [DOI] 10.3390/molecules27185923 PMC 바로가기
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenalReview Published on 2022-09-062022-10-04 Journal: Journal of Biomedical Science [Category] SARS, 변종, 신약개발, [키워드] 3CLpro 3CLpro inhibitors accelerated ACE-2 ACE2 antibody anticipated Antiviral effect approach benefit composed Conjugates conserved Coronaviruses COVID-19 COVID-19 pandemic COVID19 drug Drug discovery effort Evidence FDA approval In-vitro inhibitor Medicinal chemistry monoclonal antibodies peptide-based peptides plethora PLPro PLpro inhibitors Predictive model Prevent Proteases Protein pursuit RdRP RdRp inhibitors Replication reported required researcher S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants small molecule small molecule drug Small molecule inhibitors targets therapeutic option TMPRSS2 TMPRSS2 drug repurposing TMPRSS2 inhibitors Treatment vaccination vaccine platform Vaccines viral entry viral replication [DOI] 10.1186/s12929-022-00847-6 PMC 바로가기 [Article Type] Review
Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methodsArticle Published on 2022-09-022022-11-16 Journal: Medicine [Category] SARS, 유전자 메커니즘, [키워드] A549 cell activated Activation acute respiratory syndrome addition Analysis Atypical candidate caused characterized CLC complications CoV COVID COVID-19 COVID-19 infection cytokine deaths DEGs Determining differentially expressed gene disease drug effective experimental validation Gene Expression Omnibus gene signatures Genomics GEO GSE147507 human-to-human transmission identify IFNβ IL-17 IL-1β Illumina in silico In silico method influenza A Interaction interferon beta interferon regulatory factor IRF3 IRF9 JQ1 knowledge mechanism Methylprednisolone mock-treated pathology pathway Pneumonia Prednisolone Quality control receptors RNA RNA sequencing RNA sequencing data SARS CoV-2 signaling pathway signaling pathways small molecule STAT2 the Coronaviridae the disease therapy Transcription Treatment underlying disease upstream Viral protein virus infection was used with COVID-19 Wuhan, China [DOI] 10.1097/MD.0000000000029554 PMC 바로가기
Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesisReview article Published on 2022-09-012022-10-05 Journal: Cell Calcium [Category] SARS, 신약개발, 임상, 치료제, [키워드] acting calcium Calcium signaling Clinical management clinical trial clinical trials coronavirus disease COVID-19 COVID-19 pathogenesis Critical curtail driving drug regimen Efficacy handling homeostasis host cell Host cell calcium dynamics identify impacted Infection interact management mechanisms molecular molecular mechanism pathway Potential Protein reducing Replication reported respiratory SARS-CoV-2 SARS-COV-2 infection severity Signaling signaling cascade small molecule the disease Transport vaccination [DOI] 10.1016/j.ceca.2022.102637 [Article Type] Review article
PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19PIKfyve 특정 억제제는 시험관 내에서 여러 코로나바이러스의 복제를 제한하지만 COVID-19의 쥐 모델에서는 제한하지 않습니다Article Published on 2022-08-122022-09-11 Journal: Communications Biology [Category] 비임상, 임상, 치료기술, 치료법, 치료제, [키워드] antiviral activity apilimod approved authorization cell line claimed Community Compound COVID-19 COVID-19 pandemic disease Efficacy effort Emergency Emergency use authorization Healthcare systems human coronaviruses in vitro inhibitor Medical countermeasures multiple coronaviruses murine model nucleoside pandemic Paxlovid phase PIKfyve PIKfyve inhibitor prophylactically Protease inhibitor Remdesivir Replication Research restrict small molecule tested the United State therapeutic Therapeutics these compound these compounds Treatment Trial trials United States Vaccine writing [DOI] 10.1038/s42003-022-03766-2 PMC 바로가기 [Article Type] Article
Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In VitroME/CFS가 있거나 없는 포스트 코로나19 증후군 환자의 혈청은 체외 내피 세포 기능에 차등적으로 영향을 미칩니다Article Published on 2022-08-022022-09-11 Journal: Cells [Category] 바이오마커, [키워드] Activation analysed Angiogenesis autoantibodies autoantibody binding Cell chronic fatigue syndrome compensatory mechanism COVID-19 Cytokines demonstrated develop Diagnostic Criteria dysregulated Effect Encephalomyelitis endothelial endothelial cells Endothelial dysfunction fatigue fatigue syndrome flow cytometry function functional groups healthy control healthy controls hypothesise in vitro investigated involved marker mechanism molecules Myalgic encephalomyelitis/chronic fatigue syndrome nitric oxide Patient patient cohort patient group patient groups patients post-COVID syndrome profile promoted proportion reduced screened secretion sera serum serum cytokines significantly significantly increased small molecule Small molecules syndrome vascular remodelling was measured while [DOI] 10.3390/cells11152376 PMC 바로가기 [Article Type] Article
A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2021약리학의 1년: 2021년 미국 식품의약국 승인 신약Review Published on 2022-08-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] 신약개발, 유전자 메커니즘, [키워드] aducanumab adverse effect antibody approval approvals approved Cancer cancers class contrary COVID-19 pandemic disease drug drugs Effects Evidence evidence of FDA First-in-class First-in-indication followed by food genetic alterations had no identify indication Innovation molecular mechanism New New drugs Next Next-in-class. small molecule Small molecules target Treatment US Food and Drug Administration [DOI] 10.1007/s00210-022-02250-2 PMC 바로가기 [Article Type] Review