Small molecule inhibitors – Page 2 – Communicable Diseases Research

Identification of potent small molecule inhibitors of SARS-CoV-2 entry

SARS-CoV-2 진입의 강력한 소분자 억제제의 식별

Article

Published on 2022-01-012022-09-11
Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 변종, 신약개발, 치료제,

Phosphatidylserine receptors enhance SARS-CoV-2 infection

포스파티딜세린 수용체는 SARS-CoV-2 감염을 강화합니다

Research Article

Published on 2021-11-192022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 치료기술,

[키워드] Ablation ACE2 adhere airway apoptotic apoptotic bodies bemcentinib Betacoronavirus binding cathepsin Cell cell line cell surface receptor cell surface receptors cells contrary coronavirus correlated detect detectable Endosomal acidification ENhance entry of SARS-CoV-2 evaluated Evidence Express expressed expression facilitate facilitated Host human lung identify Infection inhibit SARS-CoV-2 inhibited inhibitor inhibitors Interaction internalization knockout Liposome mechanism MHV mouse hepatitis mouse hepatitis virus murine mutant observation pandemic coronavirus Phosphatidylcholine Phosphatidylserine pseudovirion purified receptor receptors reduce reduced SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 virions Signaling small molecule small molecule inhibitor Small molecule inhibitors Support TAM the SARS-CoV-2 therapeutic potential Vero E6 Vero E6 cell VERO E6 cells virion virus virus entry virus infection viruses
[DOI] 10.1371/journal.ppat.1009743 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs

SARS-CoV-2 감염은 여러 기관의 다른 세포에서 인터루킨-17이 풍부한 전사 반응을 시작합니다

Comparative Study

Published on 2021-08-192022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus analyzed approach CCL20 cellular Computational biology and bioinformatics concerning coronavirus CXCL1 CXCL3 CXCL8 cytokine Cytokine storm Data analysis different cell different cells etiology global public health identify IL-17 immunology Infection infections Infectious diseases Inflammation information initiate Innate immunity interleukin lung molecular molecular mechanism multiple organ Other respiratory viruses pandemic pathogenic pathway Pathways potential therapeutic target potential therapeutic targets predict regulate respiratory RNA-seq dataset SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway small molecule Small molecule inhibitors Systems biology the cytokine storm therapeutic intervention therapeutic interventions transcriptional response transcriptomic upregulated virus
[DOI] 10.1038/s41598-021-96110-3 PMC 바로가기 [Article Type] Comparative Study

SARS-CoV-2: Origin, Evolution, and Targeting Inhibition

SARS-CoV-2: 기원, 진화 및 표적 억제

Review

Published on 2021-06-172022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 진단,

[키워드] (RdRp ACE2 acute respiratory diseases acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed angiotensin angiotensin converting enzyme antibodies antibody bind carried caused China comparison complex structure coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G described drug effective enzyme Evolution help host cell in viral Infection inhibit inhibition inhibitor Invasion involved mechanism MPro mutant Neutralizing antibodies neutralizing antibody non-structural proteins origin outbreak pandemic pathogenic pathogenic mechanism physiological protease Protein proteolytic RdRP receptor recognize Replication respiratory respiratory diseases responsible RNA-dependent RNA polymerase S protein SARS-CoV-2 second wave severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 small molecule small molecule inhibitor Small molecule inhibitors Spread Structure targeting targeting inhibition therapeutic target transcription processes Viral viral genome replication viral invasion Viral RNA Wuhan
[DOI] 10.3389/fcimb.2021.676451 PMC 바로가기 [Article Type] Review

Small Molecule Compounds Identified from Mixture-Based Library Inhibit Binding between Plasmodium falciparum Infected Erythrocytes and Endothelial Receptor ICAM-1

혼합 기반 라이브러리에서 확인된 소분자 화합물이 말라리아 원충 감염 적혈구와 내피 수용체 ICAM-1 간의 결합을 억제한다.

Article

Published on 2021-05-262024-08-08
Journal: International Journal of Molecular Sciences [Category] 말라리아,

[키워드] combinatorial chemistry Drug discovery mixture-based libraries P. falciparum severe and cerebral malaria Small molecule inhibitors Solid-phase synthesis thiazoles
[DOI] 10.3390/ijms22115659 PMC 바로가기 [Article Type] Article

Suppression of SARS-CoV-2 infection in ex-vivo human lung tissues by targeting class III phosphoinositide 3-kinase

클래스 III 포스포이노시티드 3-키나아제를 표적으로 하여 생체 외 인간 폐 조직에서 SARS-CoV-2 감염 억제

Article

Published on 2021-04-012022-09-11
Journal: Journal of medical virology [Category] 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Antiviral effect approved ATG14 autophagolysosome autophagy Betacoronavirus canonical caused cellular class III PI3-K clinically complex component coronavirus coronavirus disease COVID-19 COVID-19 treatment Ex vivo ex vivo human lung tissues. examined Factor HCQ Host human lung human lung tissue Immunosuppression include Infection inhibit inhibited inhibiting inhibitor involved kinase Kinase inhibitor lysosomal novel Betacoronavirus pandemic pathway Prevent Previous studies previous study SARS-CoV-2 SARS-COV-2 infection small molecule small molecule inhibitor Small molecule inhibitors Small molecules suggested suppresse suppressed suppression tested therapeutic therapeutic target therapeutic targets tissues Transmissibility Treatment Ulk1 Vps34
[DOI] 10.1002/jmv.26583 PMC 바로가기 [Article Type] Article

Adaptation of advanced clinical virology assays from HIV-1 to SARS-CoV-2

HIV-1에서 SARS-CoV-2로의 고급 임상 바이러스 분석 적응

Review

Published on 2021-01-012022-09-11
Journal: Current opinion in HIV and AIDS [Category] 치료기술,

[키워드] adaptation analyses antiviral therapeutics applied approaches Blood conserved COVID COVID-19 pandemic disease severity Evidence genetic diversity Genetic variation HIV-1 HIV-1 infection IMPROVE infected individual infected individuals knowledge molecular Neutralizing antibodies nucleic acid outcome pandemic Pathogenesis Phylogenetic analysis plasma Precision Prognosis recent reverse transcriptase reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 sequencing sensitive sequence Sequencing shown small molecule small molecule inhibitor Small molecule inhibitors Stage susceptibility therapy Vaccines Viral viral replication Viral RNA viral RNA quantification
[DOI] 10.1097/COH.0000000000000656 PMC 바로가기 [Article Type] Review

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

Article

Published on 2020-12-212023-06-15
Journal: ACS Infectious Diseases [Category] MERS, SARS,

[키워드] autophagy coronavirus Cytopathic effect SARS-CoV-2 Small molecule inhibitors
[DOI] 10.1021/acsinfecdis.0c00349 PMC 바로가기 [Article Type] Article

Inhibition of SARS-CoV-2 Entry into Host Cells Using Small Molecules

Review

Published on 2020-12-082022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge

Review

Published on 2020-12-032022-10-30
Journal: Molecules [Category] COVID-19,