spike glycoproteins – Page 2 – Communicable Diseases Research

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination

델타의 중화 감소 (B.1.617.2) 예방 접종 후 SARS-COV-2 우려 변형

Research Article

Published on 2021-12-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 변종, 진단,

Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity

선택된 SARS-CoV-2 신흥 변이체에 대한 단일 돌연변이의 기여는 항원성을 증가시킵니다.

Article

Published on 2021-11-012022-09-11
Journal: Virology
[Category] SARS, 변종,

Different dose regimens of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373) in younger and older adults: A phase 2 randomized placebo-controlled trial

청소년 및 노인의 SARS-COV-2 재조합 스파이크 단백질 백신 (NVX-COV2373)의 상이한 용량 요법 : 2 상 무작위 위약 대조 시험

Clinical Trial

Published on 2021-10-012022-08-13
Journal: PLoS Medicine
[Category] Biochemistry, MERS, SARS, 임상, 진단,

[키워드] 95% CI 95% confidence interval accumulate addition Administered Adults adverse events age Anti-spike Antibody Response assessments assigned composed conducted convalescent sera coronavirus Day dose dose regimen Efficacy Endpoint Enrollment exceeded Follow-up Formica Frequency full-length SARS-CoV-2 geometric mean geometric mean titer geometric mean titers GMTs group groups identify IgG immune persistence immune response immune responses immunogenic immunogenicity Immunoglobulin Immunoglobulin G include inhibitory concentration intensity intramuscular dose lack limitation Matrix-M1 adjuvant median Mild mild to moderate moderate neutralizing antibody Neutralizing antibody response neutralizing antibody responses NVX-CoV2373 occurred less Older Older adults participant Participants Phase 1 Phase 2 Placebo placebo-controlled placebo-controlled trial primary endpoints Protein Randomized randomized placebo-controlled trial Randomly reactogenicity receive Recombinant spike protein regimen researcher respiratory Respiratory Coronavirus robust safety follow-up SARS-CoV-2 second dose second vaccination secondary endpoint seroconversion rate seroconversion rates severity short duration spike glycoprotein spike glycoproteins Spike protein Support The United States These data Tolerability Treatment Trial Trial registration trimeric United States USA vaccination Vaccine vaccine group wild-type virus
[DOI] 10.1371/journal.pmed.1003769 PMC 바로가기 [Article Type] Clinical Trial

Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2

Accelerated Communication

Published on 2021-08-312022-10-30
Journal: The Journal of Biological Chemistry
[Category] COVID-19, MERS, SARS,

[키워드] ACE2 ACE2 receptor ACE2, angiotensin-converting enzyme 2 acquisition AEC, airway epithelial cell angiotensin-converting enzyme 2 B.1.1.7 biochemical BLI, biolayer interferometry bypassed coronavirus COVID-19 COVID-19 pandemic dissect domain effect of temperature functional glycoprotein Host host receptor Hypothesis Impact increase in Interaction ITC, isothermal titration calorimetry Lineage mAb, monoclonal antibody N501Y N501Y mutation neutralization outbreak pandemic RBD RBD-ACE2 RBD, receptor-binding domain RBM, receptor-binding motif reflect respiratory viral infection responsible resulting SARS-CoV-2 spike spike glycoproteins suggested temperature tested the RBD the Spike translated transmissibility of SARS-CoV-2 Transmission variants of concern viability virus VOC, variant of concern VOCs VOI, variant of interest WT, wild-type
[DOI] 10.1016/j.jbc.2021.101151 PMC 바로가기 [Article Type] Accelerated Communication

A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses

SARS-CoV-2 백신 BNT162b2의 단일 용량은 Fc 매개 항체 효과기 기능 및 T 세포 반응을 유발합니다

Article

Published on 2021-07-142022-09-11
Journal: Cell Host & Microbe
[Category] MERS, SARS, 변종, 진단,

[키워드] ADCC Administered analyzed antibody antibody immunity binding domain BNT162b2 BNT162b2 mRNA vaccine CD4 cellular condition contributing to coronavirus correlation COVID-19 dose doses effective Efficacy elicit elicited Fc-mediated effector function Fc-mediated effector functions function health authorities highlight humoral humoral responses include individual infected individuals mechanism mRNA mRNA vaccine neutralization Neutralizing activity public health authority raising regimen SARS-CoV-2 single dose spike glycoproteins Support T cell T cell response T cell responses T helper the SARS-CoV-2 vaccinate Vaccine vaccine efficacy variants variants. while
[DOI] 10.1016/j.chom.2021.06.001 PMC 바로가기 [Article Type] Article

In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity

인실리코 니겔리딘(N. sativa)은 ACE1/2, AT1/2의 바이러스 스파이크/활성 부위에 결합하여 COVID-19 유발 혈관 손상/혈관 손상/동반 질환을 예방합니다

Article

Published on 2021-06-012022-08-31
Journal: Vascular pharmacology
[Category] MERS, SARS, 신약개발, 진단, 치료제,

High-throughput detection of antibodies targeting the SARS-CoV-2 Spike in longitudinal convalescent plasma samples

종적 회복기 혈장 샘플에서 SARS-CoV-2 스파이크를 표적으로 하는 항체의 고처리량 검출

Clinical Trial

Published on 2021-05-012022-09-11
Journal: Transfusion
[Category] MERS, SARS, 임상, 진단, 치료기술, 치료제,

[키워드] 293T acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antibody responses approach cell line convalescent convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses correlated COVID-19 deaths Decline detect develop domain donors expressing flow cytometry full-length SARS-CoV-2 glycoprotein help High-throughput screening Humoral response humoral responses infecting Infection information longitudinal analysis Longitudinal studies longitudinal study observation pandemic performed persistence plasma post-symptom onset RBD RBD domain RBD-specific antibodies RBD-specific antibody Receptor-binding domain reduce respiratory responses Result SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severity of COVID-19 shown specific antibodies spike spike glycoproteins Spike glycoproteins. Spike-specific antibody the RBD the receptor-binding domain the SARS-CoV-2 transfusion Viral viral entry virus
[DOI] 10.1111/trf.16318 PMC 바로가기 [Article Type] Clinical Trial

Mutations in membrane-fusion subunit of spike glycoprotein play crucial role in the recent outbreak of COVID-19

스파이크 당단백질의 막 융합 소단위의 돌연변이는 최근 COVID-19 발병에서 중요한 역할을 합니다

Article

Published on 2021-05-012022-09-11
Journal: Journal of medical virology
[Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acids Analysis analysis caused Comparative analysis coronavirus coronavirus disease coronavirus disease-2019 COVID-19 envelope Epidemic facilitate Features furin fusion peptide help Host hydrophobic intrinsically intrinsically disordered region membrane molecular molecular recognition feature nucleoprotein outbreak pandemic pathogenicity peptide performed polar preventive measure preventive measures proteolysis provide reason reported residue SARS-coronavirus SARS-CoV SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome Coronavirus spike glycoprotein spike glycoprotein. spike glycoproteins structural protein structural proteins Substitution subunit Surveillance Transmissibility transmissibility of SARS-CoV-2 viruses
[DOI] 10.1002/jmv.26598 PMC 바로가기 [Article Type] Article

Comparison of Serological Assays for the Detection of SARS-CoV-2 Antibodies

SARS-CoV-2 항체 검출을 위한 혈청학적 분석법의 비교

Comparative Study

Published on 2021-04-202022-09-01
Journal: Viruses
[Category] MERS, SARS, 진단, 치료기술,

[키워드] Antibody detection Antibody Response Antibody test antibody tests biosafety biosafety level Cohort Combination convalescent convalescent plasma coronavirus correlated strongly correlation COVID-19 COVID-19 patient cross-reactivity detect detection detection rate diagnostic discrimination Efficiency ELISA ENhance exposure to healthy individual healthy individuals hospital humans IgG IgG ELISA Infection infection with COVID-19 lentivirus neutralisation test neutralization positive provided pseudotype neutralisation Research SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 pseudotype virus SARS-CoV-2 virus SARS-CoV-2-N Screen sensitivities sensitivity serological serum severe disease spike glycoproteins utility Virus neutralisation VNT was performed
[DOI] 10.3390/v13040713 PMC 바로가기 [Article Type] Comparative Study

The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2

SARS-CoV-2의 스파이크 당단백질 구조에 대한 D614G 치환 효과

423

Published on 2021-03-022022-09-10
Journal: Proceedings of the National Academy of Sciences of
[Category] SARS, 변종,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding circulating conformation coronavirus cryo Cryo-electron microscopy cryo-EM D614G D614G substitution electron microscopy facilitate High-resolution initial isolate isolates majority membrane fusion mutant open opening priming promote reason reason for receptor receptor ACE2 reported required respiratory SARS-CoV-2 SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus Significance spike spike glycoprotein spike glycoproteins Spike protein Spike proteins spikes structural rearrangement Structure subsequent suggested the SARS-CoV-2 the spike protein variant Viral viral membrane virus virus infectivity viruses
[DOI] 10.1073/pnas.2022586118 PMC 바로가기 [Article Type] 423