Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2스파이크 의존적 옵소닌화는 용량 의존적 식균 작용 억제와 비중화 항체가 SARS-CoV-2를 보호할 수 있음을 나타냅니다Immunology Published on 2022-01-142022-09-12 Journal: Frontiers in Immunology [Category] 진단, [키워드] in vivo model antibodies antibody Antibody binding antibody function Antibody neutralization Can Concentration convalescent patient COVID19 dependent on effective effort ENhance immune function immune mechanism Immunity Increases inhibition Interaction modulation monoclonal antibody monocyte neutralize Non-neutralizing antibodies non-neutralizing antibody opsonization outcome phagocyte phagocytosis plasma protection Protein reduce reduced SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection spike spike (S) protein spike-specific antibodies Spike-specific antibody [DOI] 10.3389/fimmu.2021.808932 PMC 바로가기 [Article Type] Immunology
Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum AdjuvantsImmunology Published on 2022-01-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] acute respiratory syndrome adjuvant adjuvants Administered alum alum adjuvant antigen-specific antibody approach cartilage coronavirus coronavirus disease COVID-19 COVID-19 pandemic effective Effectiveness efficient Euglena evaluated examined expression expression vector highlight host cells induce induction Infection inoculation mice motif mouse serum neutralizing antibody optimization paramylon produced Protein purified S protein SARS-CoV-2 secreted serum Silkworm-baculovirus expression vector system spike spike (S) protein Spread subunit the S protein therapeutic agents trimeric Vaccine Vaccine development was used [DOI] 10.3389/fimmu.2021.803647 PMC 바로가기 [Article Type] Immunology
Novel Neutralizing Epitope of PEDV S1 Protein Identified by IgM Monoclonal AntibodyArticle Published on 2022-01-112022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] alphacoronaviruses antibody cause Cell clone co-immunoprecipitation disease effective epidemic diarrhea epitope Epitopes Identified IgM immunization immunogenic mAb mAbs monoclonal antibody Multiple sequence alignment Neutralization assay neutralized Neutralizing Neutralizing activity neutralizing antibody novel PEDV peptide phage mimotope porcine epidemic diarrhea virus (PEDV) Protective Protein S1 domain Safe secreted spike (S) protein strain tested the spike protein Vaccine virus virus-neutralizing western blotting [DOI] 10.3390/v14010125 PMC 바로가기 [Article Type] Article
Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in RodentsMVA 벡터 백신의 비강 내 전달은 설치류의 SARS-CoV-2에 대한 효과적인 폐 면역을 유도합니다Immunology Published on 2021-11-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] Against anti-spike antibodies anti-spike antibody Antigen applied approach Booster vaccine bronchus-associated lymphoid tissue (BALT) CD4 CD8 component delivery effective followed by hamster hamsters identify IgA IgA antibodies IgA antibody immune responses Immunity immunization induce intramuscular intranasal Local lung Lung infection Lungs memory T memory T cell memory T cells mice modified vaccinia virus Ankara (MVA) Neutralizing Neutralizing antibodies pathology priming PROTECT protocol protocols pulmonary respiratory respiratory tract rodent SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2-S serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein systemic immune response systemic immune responses T cell T cells tested Th1 Th2 titers of IgG treatment regimen vaccination Vaccine vaccine candidate vaccinia vector Viral viral infections virus Virus neutralization [DOI] 10.3389/fimmu.2021.772240 PMC 바로가기 [Article Type] Immunology
Structure-based Design of a Specific, Homogeneous Luminescence Enzyme Reporter Assay for SARS-CoV-2SARS-CoV-2에 대한 특정 균질 발광 효소 리포터 분석의 구조 기반 설계Article Published on 2021-06-252022-09-11 Journal: Journal of Molecular Biology [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody applied assays binding C-terminal catalytic activity complementary Complementation COVID-19 detectable develop diagnostic enzyme epitope Epitopes Express Gaussia Luciferase high affinity Incubation luciferase other diseases pathogenic PCA promise Protein protein-fragment complementation assay recombinant recombinant antibodies reporter reporters S-protein SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 virus sensitivity Specific specificity spike spike (S) protein steric the SARS-CoV-2 virus threat Treatment Trimers Viral viral spike Virus-like particle virus-like particles [DOI] 10.1016/j.jmb.2021.166983 PMC 바로가기 [Article Type] Article
In-Silico Evidence for a Two Receptor Based Strategy of SARS-CoV-2Molecular Biosciences Published on 2021-06-092022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] addition angiotensin-converting enzyme 2 Cell determine human cell Interaction mechanism molecular Protein Proteins quantitative assessment receptor receptors SARS-CoV-2 SARS-CoV-2 spike protein shape complementarity sialic acid spike (S) protein Strategy upper airways viral spike protein zernike moments [DOI] 10.3389/fmolb.2021.690655 PMC 바로가기 [Article Type] Molecular Biosciences
Problems associated with antiviral drugs and vaccines development for COVID-19: approach to intervention using expression vectors via GPI anchorReview Published on 2021-05-132023-06-15 Journal: Nucleosides, nucleotides & nucleic acids [Category] MERS, [키워드] Angiotensin-converting enzyme 2 (ACE2) Coronavirus disease 2019 (COVID-19) expression vectors via GPI anchor intermolecular interactions mutations Severe acquired respiratory syndrome (SARS) spike (S) protein [DOI] 10.1080/15257770.2021.1914851 PMC 바로가기 [Article Type] Review
Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection여러 막 결합 세린 프로테이나제에 의한 SARS-CoV-2 S 단백질 프라이밍은 바이러스 감염력 및 전신 COVID-19 감염을 설명할 수 있습니다Review Published on 2020-12-062022-09-12 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 진단, [키워드] α2-AP, α2-antiplasmin ACE2 ACE2, angiotensin-converting enzyme 2 activate addition Affect causative agent cause caused cell tropism circulating clinical observations Concentration contribute coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 infection COVID-19 pandemic death determine effective Exclusive or explain expression Factor HAI-1/SPINT1 heart host cells Infection infection rate information inhibitor inhibitors kidney kidney damage kidneys liver liver dysfunction Lungs MASPs, membrane-associated serine proteinases membrane fusion membrane-associated serine proteinases (MASPs) membrane-bound MERS, Middle East respiratory syndrome much higher myocardial injury Neurological complications organ other organ other organs PAI-1, plasminogen activator inhibitor 1 PCI, protein C inhibitor positive predominant proteinase QM/MD, quantum mechanical/molecular dynamics receptor relative SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS, Severe acute respiratory syndrome Sepsis Serine serine proteinase serpins significantly higher similarity spike (S) protein Spike protein SPINT1 SPINT2 structure–function relationship synergy term the disease the patient the SARS-CoV-2 thrombotic TMPRSS2 transmembrane transmission rate Treatment uPA, urokinase-type plasminogen activator Vaccine viral fusion viral spike protein viral spike proteins [DOI] 10.1074/jbc.REV120.015980 PMC 바로가기 [Article Type] Review
The 2020 Pandemic: Current SARS-CoV-2 Vaccine DevelopmentImmunology Published on 2020-08-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] antibody dependent enhancement (ADE) approved cause caused China clinical trial coronavirus 2 coronavirus disease Coronavirus disease 2019 (COVID-19) current death deaths described development effective therapy flu-like symptom Genome human coronavirus humans infect infecting Infection International MERS Middle East multi-organ failure outbreak pandemic PHEIC Pneumonia positive-sense single-stranded RNA Prevent public health emergency receptor binding domain (RBD) respiratory respiratory tract SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein Spread Vaccine virus WHO World Health Organization Wuhan [DOI] 10.3389/fimmu.2020.01880 PMC 바로가기 [Article Type] Immunology
Single Chain Fragment Variable (scFv) Antibodies Targeting the Spike Protein of Porcine Epidemic Diarrhea Virus Provide Protection against Viral Infection in PigletsArticle Published on 2019-01-142022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Administered administration antibody Antigen cause chain cloned contagious coronavirus death diarrhea effective epidemic diarrhea epitope expression fragment higher affinity IFA Infection inhibit intestinal investigated lesions less mild clinical symptoms Mortality Neonatal neutralizing antibody passive immunization PEDV plaque reduction neutralization Plasmid Porcine epidemic diarrhea virus protection protein expression scFv screened selected shown significantly significantly increased single chain fragment variable (scFv) spike (S) protein Support survival rate targeting the Spike the spike protein Treatment variable viral shedding virus [DOI] 10.3390/v11010058 PMC 바로가기 [Article Type] Article