Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA.1, BA.2 and BA.3 following third mRNA vaccination세 번째 mRNA 백신 접종 후 SARS-CoV-2 Omicron BA.1, BA.2 및 BA.3의 항체 친화도 및 교차 변이체 중화Article Published on 2022-08-082022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] addition Adults Affinity maturation antibody antibody affinity Antibody binding booster vaccination booster vaccinations breadth convalescent individual convalescent individuals cross-reactive antibody develop dose effective high affinity immune Immunity individual knowledge maturation mRNA vaccination mRNA vaccine naïve naïve individuals neutralization neutralization activity neutralization capacity neutralization titer omicron Pseudovirus neutralization assay PsVNA resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Spike protein Spike proteins spikes SPR Support surface plasmon surface plasmon resonance vaccination WA1 [DOI] 10.1038/s41467-022-32298-w PMC 바로가기 [Article Type] Article
Plasmonic Approaches for the Detection of SARS-CoV-2 Viral ParticlesSARS-CoV-2 바이러스 입자 검출을 위한 플라즈몬 접근법Review Published on 2022-07-212022-09-11 Journal: Biosensors [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody treatment applicability approach Care caused contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detection diagnostic diagnostic testing diagnostics focus genetic material highlight Highlights Infection infectivity testing neutralizing antibody non-infected nucleocapsid outbreak pandemic Particle Patient platform POCT point-of-care point-of-care testing Protein provided respiratory reverse transcription PCR RT-PCR S1 protein SARS-CoV-2 SARS-CoV-2 viral particle SARS-CoV-2 viral particles SARSC-CoV-2 severe acute respiratory syndrome Coronavirus spike glycoprotein spike glycoproteins Spike protein SPR structural proteins surface plasmon surface plasmon resonance surface plasmonic resonance (SPR). the S1 protein therapeutic Treatment Vaccine Viral viral particle Viral particles Viral protein virus while [DOI] 10.3390/bios12070548 PMC 바로가기 [Article Type] Review
Equine Anti-SARS-CoV-2 Serum (ECIG) Binds to Mutated RBDs and N Proteins of Variants of Concern and Inhibits the Binding of RBDs to ACE-2 Receptor말 항-SARS-CoV-2 혈청(ECIG)은 돌연변이된 RBD 및 관심 변이의 N 단백질에 결합하고 ACE-2 수용체에 대한 RBD의 결합을 억제합니다Article Published on 2022-07-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] accumulate accumulated mutation accumulated mutations ACE-2 Alpha angiotensin angiotensin-2 converting enzyme anti-SARS-CoV-2 appearance attenuate B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 benefit Beta bind binding caused cell entry concern Course COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients death Delta diagnosed disease domain domains effective ENhance equine equine serum experiment Gamma generate greater Host host cell Immunoglobulin infect Infection interact lethality limit mutated Mutation mutations Neutralizing Neutralizing activity Neutralizing antibodies notable nucleocapsid nucleocapsid protein Nucleocapsid proteins omicron Prevent RBD RBD region receptor Recombination reduce reducing reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Spike protein SPR Spread surface plasmon surface plasmon resonance syndrome the disease the spike protein therapy variant variants Viral viral entry virus VoC VOCs VOI VOIs wild-type [DOI] 10.3389/fimmu.2022.871874 PMC 바로가기 [Article Type] Article
A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies고친화도 및 강력한 SARS-CoV-2 중화 항체의 분리 및 특성화를 위한 새로운 고처리량 단일 B 세포 클로닝 플랫폼Article Published on 2022-07-012022-09-12 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE-2 receptor antibody B-cell binding Blood coronavirus COVID-19 Critical diagnosing Diseases domain effective ELISA high affinity highlight human cell Isolation mAb mAbs mAbs. Neutralizing Neutralizing activity neutralizing antibody Patient platform RBD RBD domain reporter S1 subunit SARS-CoV-2 SARS-CoV-2 neutralizing antibody single B cell Single B-cell cloning SPR Strategy the RBD the spike protein was used Wuhan-Hu-1 [DOI] 10.1016/j.antiviral.2022.105349 PMC 바로가기 [Article Type] Article
Regenerable and high-throughput surface plasmon resonance assay for rapid screening of anti-SARS-CoV-2 antibody in serum samples혈청 샘플에서 항-SARS-CoV-2 항체의 신속한 스크리닝을 위한 재생 가능한 고처리량 표면 플라즈몬 공명 분석Article Published on 2022-05-222022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acid acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition anti-SARS-CoV-2 antibody antibody Antibody test antibody tests association can not channel clinical sample clinical samples Concentration Convalescent patients coronavirus current Detection limit effective ELISA ELISA kit enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay exhibit fluorescent High-throughput histidine mass offer Protein reached reagents reduced reproducibility respiratory S1 protein SARS-CoV-2 SARS-CoV-2 spike sensor serological serological measurement serological measurements serum sample serum samples severe acute respiratory syndrome Coronavirus speed SPR surface plasmon surface plasmon resonance threshold value tris tris-NTA chip. [DOI] 10.1016/j.aca.2022.339830 PMC 바로가기 [Article Type] Article
Healthy humans can be a source of antibodies countering COVID-19건강한 사람은 COVID-19에 대항하는 항체의 원천이 될 수 있습니다Article Published on 2022-05-012022-09-11 Journal: Bioengineered [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 ACE2 competitor Analysis angiotensin angiotensin-converting enzyme 2 antibody antibody cocktail approach authentic SARS-CoV-2 virus best binding binding affinity Blood bypassing can be used characterized Combination COVID-19 COVID-19 diagnostics COVID-19 therapeutics detect detecting antibody diagnostic eight ELISA epitope Epitopes Evidence Evolution flow cytometry fluorescence microscopy healthy donor healthy donors Human humanized IgG immune in vitro infected patients Infection inhibit SARS-CoV-2 Isolation mice monoclonal antibodies naïve neutralization titers neutralize neutralizing antibody RBM receptor Receptor binding domain receptor-binding motif recognize SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus single B cell single-chain antibody specificity Spike protein SPR tested therapeutic unique virus infection yeast [DOI] 10.1080/21655979.2022.2076390 PMC 바로가기 [Article Type] Article
Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants인간 ACE2의 미스센스 변이체는 코로나19에서 ACE2 매개 유전적 위험에 대한 메커니즘을 제공하는 SARS-CoV-2 스파이크에 대한 결합에 강한 영향을 미칩니다. 인터페이스 변이체의 친화도 예측 사례 연구Article Published on 2022-03-022022-09-11 Journal: PLoS Computational Biology [Category] 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 variant ACE2 variants Affect affinity African allele angiotensin bind binding calculated calibration Cell cell types Cohort cohorts distribution ENhance European experiment genetic risk gnomAD greater human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Infection inhibited Interaction Kinetics mechanism missense variant parameter predicted predominant Prevalence PROTECT pseudotype receptor Receptor binding domain reduce reduced SARS-CoV-2 SARS-CoV-2 spike selected spike Spike receptor binding domain SPR strength surface plasmon surface plasmon resonance the Spike this system tissue tissues utility variant variants virulence ΔΔG [DOI] 10.1371/journal.pcbi.1009922 PMC 바로가기 [Article Type] Article
Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide PolysulfateArticle Published on 2022-02-212022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] ACE2 activity addition angiotensin-converting enzyme 2 anti-SARS-CoV-2 activities antiviral activity binding Cell competitive binding Compound compounds COVID-19 pandemic Delta demonstrated domain evaluated exhibited fucoidans glycan glycans Health heparan sulfate heparin Host host cell host cell receptor in vitro inhibited Interaction killing MPS much lower Mucopolysaccharide mucopolysaccharide polysulfate new SARS-CoV-2 omicron Pentosan pentosan polysulfate Potential PPS Prevalence previous study Protein pseudotyped lentiviral particle pseudotyped viral particle RBD RBD binding S-protein SARS-CoV-2 SPR sulfated surface plasmon resonance variants variants of concern viral infectivity wild type wild-type [DOI] 10.3390/ph15020258 PMC 바로가기 [Article Type] Article
Discovery of Camellia sinensis catechins as SARS-CoV-2 3CL protease inhibitors through molecular docking, intra and extra cellular assays분자 도킹, 세포내 및 세포외 분석을 통한 SARS-CoV-2 3CL 프로테아제 억제제로서의 동백나무 카테킨 발견Article Published on 2022-02-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] COVID19(2023년), SARS, 치료기술, [키워드] (-)-epicatechin (–)-epicatechin 3-O-caffeoate 3CL 3CLpro Amino acid amino acid residue amino acid residues ASN142 AutoDock binding energy Camellia Camellia sinensis catechins cellular chymotrypsin conducted configuration cysteine cysteine protease detection system dissociation Dissociation constant Ebselen ebselen. ECG Epicatechin Extracellular gallate GCG GLN189 Gly143 HIS163 inhibit inhibitors inhibitory activity Modification molecular docking Previous studies previous study Protease inhibitor SARS-CoV-2 selected SPR suggested surface plasmon surface plasmon resonance THR26 was used [DOI] 10.1016/j.phymed.2021.153853 PMC 바로가기 [Article Type] Article
Ultrasensitive detection of SARS-CoV-2 nucleocapsid protein using large gold nanoparticle-enhanced surface plasmon resonanceArticle Published on 2022-01-202022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] coronavirus COVID-19 pandemic Detection sensitivity Gold nanoparticle highest Imaging and sensing limit of detection N protein Optical materials and structures Protein resulting SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid significantly SPR the SARS-CoV-2 [DOI] 10.1038/s41598-022-05036-x PMC 바로가기 [Article Type] Article