Estimating SARS-CoV-2 variant fitness and the impact of interventions in England using statistical and geo-spatial agent-based models통계 및 지리 공간 에이전트 기반 모델을 사용하여 SARS-CoV-2 변종 적합도 및 영국에서의 개입 영향 추정Article Published on 2022-10-032022-09-11 Journal: Philosophical transactions. Series A, Mathematical [Category] COVID19(2023년), SARS, 변종, [키워드] agent agent-based model Alpha B.1.1.7 B.1.177 death distribution dominant variant effective England Epidemics estimate Evolution example geo-spatial model Intervention Lineage lockdown lockdowns prevented relative reopening replaced REPLACED BY Reproduction number robustness SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 variant Spread statistical statistical model the epidemic Transmissibility vaccination Vaccinations variant variants Variation Viral variants virus variants [DOI] 10.1098/rsta.2021.0304 PMC 바로가기 [Article Type] Article
Diagnostic performance of the SARS-CoV-2 S1RBD IgG ELISA (ImmunoDiagnostics) for the quantitative detection of SARS-CoV-2 antibodies on dried blood spotsArticle Published on 2022-10-012022-11-15 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] absence analysed Anti-spike antibodies Antibody detection Blood Concentration concentrations correlated correlation cut-off cut-off value dried blood spot Dried blood spots (DBS) ELISA ELISA kit enzyme-linked immunosorbent assay Enzyme-linked immunosorbent assay (ELISA) Euroimmun evaluate Follow-up humoral IgG IgG ELISA immune responses increasingly International Units/mL MONITOR Pearson correlation performed quantification Quantitative reference method SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 S1 SARS-CoV-2 surveillance sensitivity Sensitivity and specificity serology Serosurveillance serum serum antibody serum samples specificity spot statistical the SARS-CoV-2 vaccination vaccine responses was used [DOI] 10.1016/j.jcv.2022.105270 PMC 바로가기
Five-week warning of COVID-19 peaks prior to the Omicron surge in Detroit, Michigan using wastewater surveillanceResearch article Published on 2022-10-012022-10-05 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition authority average city collected Community Concentration conducted confirmed COVID-19 case correlated correlation COVID-19 COVID-19 case COVID-19 incidence Daily Detroit early warning effective Epidemiology evaluated explain fluctuation Genes Great Lake indicated N1 and N2 normalized omicron Outbreaks parameter parameters prediction quantified ranged SARS-CoV-2 statistical statistical model study period Surveillance Wastewater-based-epidemiology (WBE) water [DOI] 10.1016/j.scitotenv.2022.157040 [Article Type] Research article
Performance assessment and improvement of a care unit for COVID-19 patients with resilience engineering and motivational factors: An artificial neural network methodResearch article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] 변종, [키워드] Algorithm Analysis Artificial neural network asked Care Combination Complete COVID-19 COVID-19 patient Data envelopment analysis detrimental disease evaluate healthcare providers Healthcare system hospital Hospital staff IMPROVE indicated investigated Job satisfaction motivational factor New coronavirus performance Performance evaluation performed physical questionnaire required Resilience Resilience engineering sensitivity analysis significant increase statistical statistical test Threats was determined [DOI] 10.1016/j.compbiomed.2022.106025 [Article Type] Research article
Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjectsArticle Published on 2022-09-302022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 치료제, [키워드] affected age antiviral drug approved association baseline blood sample BMI calculated collected comparison Concentration COVID-19 COVID-19 patients COVID-19 severity Efficacy enrolled evaluated glomerular filtration rate GS-441524 ICU identify independent predictor Inpatient Inpatients inter-individual Liver function Logistic regression metabolite Multiple linear regression Multiple regression analysis parameter Patient pharmacokinetic plasma Remdesivir renal renal function required Research SARS-CoV-2 SARS-CoV-2 infections Sex Standard-dose statistical subject transaminase treated Treatment Variability variables were assessed were measured were used [DOI] 10.1093/jac/dkac234 PMC 바로가기
Projection in genomic analysis: A theoretical basis to rationalize tensor decomposition and principal component analysis as feature selection toolsArticle Published on 2022-09-292022-11-16 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] addition adjusted applied Biomarker Cancer Cluster Conventional COVID-19 Critical data set data sets described differentially expressed gene distribution Drug discovery gaussian distribution Genes genomic identifying kidney null hypothesis P-value PCA principal component analysis projection pursuit Sample size statistical statistical test Tensor These data threshold treated vector [DOI] 10.1371/journal.pone.0275472 PMC 바로가기
A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic CardiomyopathyArticle Published on 2022-09-272022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome Affect Analysis Bioinformatic Biology Biomarker Cardiomyopathy cardiovascular system Combination conducted coronavirus coronavirus disease COVID-19 COVID-19 progression datasets DEGs differentially expressed gene disorder drug drug candidates Effect functional Gene Expression Omnibus Genes Genetic GSE147507 identify individual knowledge Lungs microRNA mortality rate; ontology terms other organs patients with COVID-19 protein-protein interaction Proteins Research RNA SARS-CoV-2 Sequencing shared pathway shown statistical Support System therapy transcription factors transcriptomic while [DOI] 10.1155/2022/5337380 PMC 바로가기
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthmaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] addition allergic Allergic asthma Analysis approach association Asthma asthmatic bioinformatics Biomarker can be used candidate drug candidate drugs Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression COVID-19 symptom Critical dataset datasets DEGs determine differentially expressed gene disease disease biomarker drug Effect elevated Evidence expression level Gene ontology Genes health systems hub gene identify IL-13 IL-5 Increasing Interaction interactions lung mechanism molecular molecular mechanism MUC5AC murine murine model pandemic pathway Pathway analysis Patient patients with COVID-19 phenotype potential molecular risk factor severity shared pathways statistical Systems biology systems-biology. Transcription [DOI] 10.3389/fimmu.2022.988479 PMC 바로가기
Variant-Specific Analysis Reveals a Novel Long-Range RNA-RNA Interaction in SARS-CoV-2 Orf1aArticle Published on 2022-09-212022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 receptor Affect aggregate analyses Analysis Beta binding affinity change changes compensatory mutations COVID-19 COVID-19 pandemic de novo Evidence feature human lung cell identify in silico in vivo information Interaction knowledge novel pathogenicity pathology Protein recent researchers RNA RNA structure RNA virus RNA-RNA interaction RNA-RNA interactions SARS-CoV-2 SARS-CoV-2 sequences sequence spike statistical the SARS-CoV-2 the SARS-CoV-2 genome variant viral evolution viral pathogenicity viral variant virus [DOI] 10.3390/ijms231911050 PMC 바로가기
Clinical trial and detection of SARS-CoV-2 by a commercial breath analysis test based on Terahertz technologyArticle Published on 2022-09-202022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] Algorithm Analysis Asymptomatic Brazil breath clinical Compound correlation COVID-19 diagnosing Diagnostic method evaluate gold standard Health Infection International Local National non-infected noninvasive organic Pandemics Patient Public Rapid required respiratory diseases RT-qPCR SARS-CoV-2 SARS-CoV-2 positivity screening method sensitivity social isolation specificity statistical tested the SARS-CoV-2 threat Trial virus [DOI] 10.1371/journal.pone.0273506 PMC 바로가기