A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike인간화된 나노바디 파지 디스플레이 라이브러리는 SARS CoV-2 스파이크의 강력한 결합제를 생성합니다Article Published on 2022-08-102022-09-11 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] (alpha affinity antibody antibody treatment B.1.1.7 binding modes complex effective Ex vivo humanized mitigate molecular dynamics Molecular dynamics simulation molecular dynamics simulations N501Y N501Y mutation nanobodies nanobody neutralization Neutralizing Neutralizing antibodies primary human airway RBD RBD mutation reducing SARS CoV-2 SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 spike protein SARS-CoV-2 variants shown Spike protein Structural analysis the SARS-CoV-2 variant Viral viral burden WA1 [DOI] 10.1371/journal.pone.0272364 PMC 바로가기 [Article Type] Article
Understanding the mutational frequency in SARS-CoV-2 proteome using structural features구조적 특징을 이용한 SARS-CoV-2 프로테옴의 돌연변이 빈도 이해Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Cluster collected computational approach coronavirus COVID-19 develop Early detection feature Features Frequency human population machine machine learning machine learning model machine learning models mutability mutated Mutation mutations pandemic physicochemical predict Protein Protein mutability proteome provided reduced residue SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 sequence SARS-CoV-2 sequences Sequence conservation severe acute respiratory syndrome Coronavirus severity stability Structural analysis survival the SARS-CoV-2 threshold Transmission understanding unique variants variants of concern viral isolate viral isolates Viral protein viral strains virus [DOI] 10.1016/j.compbiomed.2022.105708 PMC 바로가기 [Article Type] Article
Culture and identification of a “Deltamicron” SARS-CoV-2 in a three cases cluster in southern France프랑스 남부의 3개 사례 클러스터에서 "델타마이크론" SARS-CoV-2의 배양 및 식별Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] backbone binding Chain Reaction clinical feature Cluster Co-infection codon Codons composed Coronaviruses Delta deltamicron Diagnosis electron microscopy Epidemic epidemiological France full-length Genetic Genome host cell host cell membrane Infection isolate Lineage lineages Microscopy Multiple Mutation nucleotide omicron polymerase chain polymerase chain reaction qPCR Quantitative quantitative polymerase chain reaction recombinant reported SARS-CoV-2 SARS-CoV-2 variant scanning electron microscopy sequenced sequencing depth spike gene Spread Structural analysis suggested summer supported variant Virological [DOI] 10.1002/jmv.27789 PMC 바로가기 [Article Type] Article
Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variantsSARS-CoV-2 및 그 변이체에 T 세포 교차 보호를 부여하는 바이러스 면역원성 발자국Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E 3D structure 3D Structures approach Asymptomatic case Asymptomatic cases CD8+ T cell cellular cellular response concern conserved contributing to Coronaviruses COVID-19 cross-protection cross-reactivity death disease Endemic epitope Epitopes examination expected explain explanation Features Genetic Heterologous HLA-A HLA-A*02:01 human coronaviruses human coronaviruses 229E human infection Immunity immuno informatics immunogenic immunogenic feature immunogenicity include indicate individual individuals infected individuals Infection involved molecular OC43 other coronaviruses outcomes pathogen Pathogens peptide peptides physicochemical Population SARS-CoV SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 sequence sequence Sequence analysis severe disease Structural analysis Structure T cell T-cell T-cell epitopes target Trigger uninfected Vaccine development variant variants virus viruses Wuhan [DOI] 10.3389/fimmu.2022.931372 PMC 바로가기 [Article Type] Article
Molecular modelling identification of phytocompounds from selected African botanicals as promising therapeutics against druggable human host cell targets of SARS-CoV-2SARS-CoV-2의 약물 가능한 인간 숙주 세포 표적에 대한 유망한 치료제로서 선택된 아프리카 식물의 식물 화합물의 분자 모델링 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome coronavirus African Amino acid amino acid residue angiotensin Angiotensin converting enzyme-2 bafilomycin binding binding energy candidate drug cathepsin cathepsin L caused Cell clinical evaluation clinical evaluations Compound compounds Computational methods coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical enzyme galactoside hACE2 highly pathogenic host cell Host cell targets human cell human cells human host in vitro inhibitor inhibitors of TMPRSS2 inhibitory inhibitory action investigated kaempferol mechanism MLN-4760 Modification modifications modulate molecular dynamics Molecular dynamics simulation myricetin nafamostat Phytocompounds Protein Proteins Replication Research respiratory Respiratory disease respiratory diseases rutinoside SARS-CoV-2 selected Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structural analysis subjects subsequent target Therapeutic benefit these compound these compounds TMPRSS2 transmembrane serine protease Verbascoside viral entry viral spike protein viral spike proteins while [DOI] 10.1016/j.jmgm.2022.108185 PMC 바로가기 [Article Type] Article
Analysis of a SARS-CoV-2 convalescent cohort identified a common strategy for escape of vaccine-induced anti-RBD antibodies by Beta and Omicron variantsSARS-CoV-2 회복기 코호트 분석에서 베타 및 오미크론 변이체에 의한 백신 유도 항-RBD 항체의 탈출을 위한 공통 전략 확인Article Published on 2022-06-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S allergy Alpha Analysis anti-RBD Anti-RBD antibody anti-spike antibody antibody Antibody binding Antibody Response antibody response against Antibody titer Antibody titers assays Beta blood draw blood draws blood sample BNT162b2 Boston Cohort collected convalescent COV2.S COVID COVID-19 cross-reactive antibodies cross-reactive antibody Delta Donor evade evaluate expected fraction hybrid Hybrid immunity Immune escape immune evasion Immunity increase increase in Infectious disease Infectious diseases initial limitation Massachusett mRNA mRNA-1273 mutant Mutation neutralization Neutralization escape mutations omicron Omicron variant plasma polyclonal polyclonal antibody Post-infection proportion proportions Proteins RBD RBDs Re-infection readiness Receptor binding domain residue residues SARS-CoV-2 SARS-CoV-2 variants spike Spike protein Structural analysis the spike protein vaccination Vaccine induced antibody titers. variant variants variants of concern were excluded were used [DOI] 10.1016/j.ebiom.2022.104025 PMC 바로가기 [Article Type] Article
Mutations of the SARS-CoV-2 Spike Glycoprotein Detected in Cats and Their Effect on Its Structure and Function고양이에서 검출된 SARS-CoV-2 스파이크 당단백질의 돌연변이와 구조 및 기능에 미치는 영향Article Published on 2022-06-012022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 receptor addition Analysis angiotensin Angiotensin-converting enzyme binding cats cell receptor Critical Effect ENhance facilitate Frequency function help highlight homology Host host receptor host susceptibility hosts Human indication Interaction investigated modeling molecular Mutation mutations Neutralizing antibodies provided reported residue respiratory S1/S2 cleavage SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 spike glycoprotein Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 spike spike glycoprotein Structural analysis Structure Substitution the SARS-CoV-2 viral infectivity virus [DOI] 10.3389/fcimb.2022.875123 PMC 바로가기 [Article Type] Article
Structural insights revealed by crystal structure of B38-CAP, an isoenzyme of carboxypeptidase ACE2, the receptor of SARS-CoV-2SARS-CoV-2의 수용체인 카르복시펩티다제 ACE2의 동종효소인 B38-CAP의 결정 구조로 밝혀진 구조적 통찰력Article Published on 2022-05-282022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 carboxypeptidase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 B38-CAP carboxypeptidase catalysis catalytic coincidence complex interplay conformational flexibility coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 crystal structure dimeric domain drugs enzyme feature Host Isoenzyme problem provide provided RAS receptor Renin renin-angiotensin system sACE2 SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus specificity Structural analysis Treatment treatment of COVID-19 triggered variety weakened worldwide pandemic worsened [DOI] 10.1016/j.bbrc.2022.03.077 PMC 바로가기 [Article Type] Article
Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron3개의 SARS-CoV-2 항체는 Omicron을 포함한 관심 변이체에 대해 광범위하고 상승적인 중화를 제공합니다.Article Published on 2022-05-242022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail Beta convalescent patient convalescent sera coronavirus Coronaviruses COVID-19 CP: Immunology Critical determinant hamsters highlighting immunology Infection inhibitory concentration Interaction maintain NAb NAbs nanomolar affinity neutralization Neutralizing antibodies neutralizing antibody omicron Omicron variant provide RBDs receptor-binding domains respiratory resulting reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 antibody severe acute respiratory syndrome Coronavirus spike Structural analysis synergistic the receptor-binding domain therapeutic Vaccine Vaccines variant variants of concern VOCs wild-type [DOI] 10.1016/j.celrep.2022.110862 PMC 바로가기 [Article Type] Article
2′- and 3′-Ribose Modifications of Nucleotide Analogues Establish the Structural Basis to Inhibit the Viral Replication of SARS-CoV-2뉴클레오티드 유사체의 2'- 및 3'-리보스 변형은 SARS-CoV-2의 바이러스 복제를 억제하는 구조적 기초를 확립합니다Article Published on 2022-05-122022-09-11 Journal: The journal of physical chemistry letters [Category] COVID19(2023년), SARS, 치료제, [키워드] active site adenosine Affect analogue Antiviral Basis evaluated extension inhibition Modification molecular molecular dynamics nucleotide nucleotide analogue nucleotide analogues Protein provide RdRP Remdesivir ribose RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp shown stability Structural analysis Treatment [DOI] 10.1021/acs.jpclett.2c00087 PMC 바로가기 [Article Type] Article