Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics ApproachSARS-CoV-2 구조 단백질의 게놈 변이와 발병에 미치는 해로운 영향: 비교 게놈 접근Cellular and Infection Microbiology Published on 2021-10-132022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 치료법, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Affect Analysis association Comparative Comparative genomics coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 creating envelope Enzymes failure functional consequence Genomics Health Impact Infection M pro mechanism membrane mutated Mutation nucleocapsid Pathogenesis performed protease Protein RdRP Replication respiratory rising RNA-dependent RNA polymerase S protein SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 pathogenesis selected sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 single amino acid substitutions small molecule structural protein structural proteins Structural variation structural variations structure-function Surface glycoprotein therapeutic approaches Therapeutic strategies Variation [DOI] 10.3389/fcimb.2021.765039 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
In silico Exploration of Interactions Between Potential COVID-19 Antiviral Treatments and the Pore of the hERG Potassium Channel—A Drug AntitargetCardiovascular Medicine Published on 2021-05-042022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] abnormality absence Antitarget Antiviral antiviral drug antiviral treatments approach aromatic residue arrhythmia Atazanavir binding binding pockets binding site canonical Combination component computational modeling Contact COVID-19 cryo-EM structure determinant docked domain drug drugs ECG exploration Favipiravir FIVE hERG human ether-à-go-go–related gene in silico include inhibit Interaction less Lopinavir Lopinavir-ritonavir Pore potassium channel Potential reduced Remdesivir residue residues risk Ritonavir SARS-CoV-2 structure-function torsades de pointe Treatment [DOI] 10.3389/fcvm.2021.645172 PMC 바로가기 [Article Type] Cardiovascular Medicine
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced seraArticle Published on 2021-04-292022-10-31 Journal: Cell [Category] COVID-19, MERS, SARS, [키워드] abrogate Abstract ACE2 ACE2 binding acute respiratory syndrome Analysis angiotensin-converting enzyme-2 antibody AstraZeneca B.1.351 binding Brazil changes in convalescent coronavirus domain driven by E484K escape evidence of facilitate form Immune escape immunodominant K417N large cohort Lineage mAb monoclonal antibody Mutation N501Y neutralization neutralization titer Neutralizing NTD offer P.1 Pfizer receptor receptor ACE2 Receptor-binding domain reduced reveal SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 variant sequence sera serum serum sample serum samples South Africa Spike protein structure-function the SARS-CoV-2 vaccinated individual Vaccine vaccinee variant viral cell viral spike protein widespread [DOI] 10.1016/j.cell.2021.02.037 PMC 바로가기 [Article Type] Article
Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 생물의학적 개입으로 인한 급격한 진화 탈출의 위험Research Article Published on 2021-04-282022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 affinity Analysis antibody antibody-based prophylactics comparable COVID-19 Critical Decay kinetics deleterious mutation develop domain epitope Epitopes escape mutant escape mutants expected focus Frequency Genetic variation Immune escape immune evasion Immunity immunization in vitro infect cell Intervention molecular molecular target Mutation NAb NAbs natural antigens natural immunity Neutral Neutralizing antibodies neutralizing antibody new strain overlap passive immunization Positive selection potential mechanism predict question raise raised raising RBD RBD-targeting nAbs SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 spike protein sequence Spike protein Strategy structure-function surveillance data the RBD therapeutic timeline Transmissibility vaccinal Vaccine Vaccines Viral Viral immune evasion virus virus escape neutralizing antibodies widespread wild type [DOI] 10.1371/journal.pone.0250780 PMC 바로가기 [Article Type] Research Article
Why Are Viruses Spiked?Perspective Published on 2021-02-172022-10-30 Journal: mSphere [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Antiviral approach attacking binding Cell colloid coronavirus determine Environment facilitate favor fusion HIV Human immunodeficiency virus implication Interaction membrane fusion occur Particles receptor-specific interaction Release SARS-CoV-2 spike spikes structure-function Transport Vaccine viral tropism virus Virus spike Virus-like particle viruses [DOI] 10.1128/mSphere.01339-20 PMC 바로가기 [Article Type] Perspective
Structure of Nonstructural Protein 1 from SARS-CoV-2SARS-CoV-2의 비구조 단백질 1의 구조Article Published on 2021-01-282022-09-11 Journal: Journal of Virology [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter Antiviral antiviral therapy carboxyl causative agent cellular city clone conformation coronavirus Coronavirus replication CoV COVID-19 COVID-19 pandemic CoVs Critical crystal structure cultured cells Deletion effective vaccine Effective vaccines element facilitate Factor Features flexible function Health high-resolution crystal structure Host host cell infecting inhibit innate immune response life cycle live-attenuated vaccines mechanism molecular mRNA degradation Mutation nonstructural protein 1 Novel coronavirus novel coronaviruses nsp1 Occurrence Pneumonia prevented promote Protein public health recruited respiratory Respiratory illness reveal SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 NSP1 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe respiratory illness shown Structure structure-function Support target therapeutic option translation turn underlie Vaccine design Vaccine development Viral viral life cycle virus virus infection Wuhan Wuhan, China X-ray X-ray crystallography [DOI] 10.1128/JVI.02019-20 PMC 바로가기 [Article Type] Article
Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune EvasionArticle Published on 2020-07-282022-10-28 Journal: Viruses [Category] COVID-19, [키워드] alphacoronavirus alphacoronavirus nsp1 Analysis Basis Betacoronavirus Biological biological function Cell cell cycle cell cycle genes Cellular immune response characterized composed conserved creating crystal structure experiment full-length Host host cell host protein host proteins IFN IFN-I immune Infectious disease inhibit inhibiting inhibitory effect interfere interferon mammalian cell mechanism PEDV Phosphorylation proliferation Protein regulate regulated Regulatory Renilla luciferase RNA sequence RNA sequencing selected Seven significantly structure-function structures subtype TGEV treated Viral virulence virus western blotting β-CoV β-CoVs [DOI] 10.3390/v12080812 PMC 바로가기 [Article Type] Article
Molecular analysis of an enigmatic Streptococcus pneumoniae virulence factor: The raffinose-family oligosaccharide utilization system수수께끼 같은 폐렴구균 병원성 인자의 분자 분석: 라피노스 계열 올리고당 이용 시스템Article Published on 2019-11-152024-08-24 Journal: Brain stimulation [Category] 폐렴구균 감염증, [키워드] galactosidase glycoside hydrolase host-pathogen interaction pneumococcus raffinose-family oligosaccharide (RFO) Streptococcus structure-function virulence factor X-ray crystallography
The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence *살모넬라 효과 인자 SpvD는 카탈리틱 활성, 면역 반응 억제 및 박테리아 병원성에 영향을 미치는 세로바 특이적 다형성을 가진 시스테인 하이드롤라제입니다.Article Published on 2016-12-092024-07-29 Journal: Brain stimulation [Category] 살모넬라증, [키워드] Bacterial pathogenesis crystal structure cysteine protease effector Salmonella enterica structure-function [DOI] 10.1074/jbc.M116.752782 PMC 바로가기