Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age5~11세 어린이의 오미크론에 대한 BNT162b2 백신 효과Article Published on 2022-07-212022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age BNT162b2 BNT162b2 vaccine calculated Care children Cohort Control controls coronavirus coronavirus disease Coronavirus disease 2019 cumulative cumulative incidence dominant variant dose Effectiveness eligible European event Evidence first dose Health Health care incidence Infection Kaplan-Meier estimator Limited Messenger RNA moderate of BNT162b2 omicron Omicron variant outcome provided risk risk difference risk ratio RNA vaccine SARS-CoV-2 SARS-COV-2 infection second dose severe acute respiratory syndrome Coronavirus study group study groups study period subgroups symptomatic COVID-19 the study group the vaccine union Vaccine vaccine doses Year [DOI] 10.1056/NEJMoa2205011 PMC 바로가기 [Article Type] Article
Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study중요한 COVID-19에서 정맥내 IgM이 풍부한 면역글로불린: 다기관 성향 가중 코호트 연구Multicenter Study Published on 2022-07-072022-09-12 Journal: Critical Care [Category] COVID19(2023년), SARS, 진단, [키워드] 30-Day mortality acute respiratory distress addition applied Characteristics clinical clinically Cohort cohort study Complication concerning confidence interval controls coronavirus disease COVID-19 COVID-19 patients Cox regression models Critical Critically ill Critically ill patient daily dose dose early administration Effect Efficacy high mortality ICU ICU Patients Immunoglobulin immunoglobulin M immunoglobulins Inflammatory intravenous laboratory-confirmed Lung injury mechanical ventilation mechanically ventilated Mortality multicentre overcome Patient Primary outcome randomization randomized clinical trials retrospective SARS-CoV-2 selection bia statistical significance statistically statistically significant difference subgroup analysis subgroups survival treated Treatment treatment regimen two group was performed Weighting with COVID-19 [DOI] 10.1186/s13054-022-04059-0 PMC 바로가기 [Article Type] Multicenter Study
Peripheral lymphocyte subset counts predict antibody response after SARS-CoV-2 mRNA-BNT162b2 vaccine in cancer patients: Results from the Vax-On-Profile study말초 림프구 하위 집합 수는 암 환자에서 SARS-CoV-2 mRNA-BNT162b2 백신 후 항체 반응을 예측합니다: Vax-On-Profile 연구 결과Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Adaptive immune response Analysis anti-RBD Antibody Response Antibody titer Antibody titers B cell B cells Cancer cancer patient Cancer patients Chemotherapy circulating collected correlation Corticosteroid corticosteroid therapy COVID-19 COVID-19 vaccination Cytotoxic chemotherapy defined Flow cytometry analysis helper cell humoral humoral immunogenicity Humoral response IgG IgG antibodies IgG antibody IgG titer immunosuppressive indicated interactions linear correlation lymphocyte Lymphocyte subset Lymphocyte subsets mRNA Multivariate analysis Negative predictive value Occurrence Patient peripheral Peripheral blood positive positive linear correlation predict Predictive Predictive value Protein Quantitative RBD receiving Receptor-binding domain Result ROC Curve SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine seroconversion rate seroconversion rates seroconversion response serologic testing Serologically shown significantly spike Spike protein subgroups subpopulations subset symptomatic infections T helper T helper cell T helper cell. tested the receptor-binding domain the SARS-CoV-2 treated Univariate analysis vaccination efficacy Vaccine [DOI] 10.1016/j.intimp.2022.108774 PMC 바로가기 [Article Type] Article
A Prospective Observational Cohort Comparison of SARS-CoV-2 Seroprevalence Between Paramedics and Matched Blood Donors in Canada During the COVID-19 PandemicCOVID-19 팬데믹 기간 동안 캐나다에서 구급대원과 일치된 헌혈자 사이의 SARS-CoV-2 혈청 유병률의 예측 관찰 코호트 비교Observational Study Published on 2022-07-012022-09-11 Journal: Annals of emergency medicine [Category] COVID19(2023년), SARS, 임상, 치료법, [키워드] 1:1 95% CI 95% confidence interval age antibody Blood blood collection blood donor Blood donors both groups Canada Characteristics Comparisons COVID-19 defined demonstrated Donor donor sample Elecsys Evidence evidence of identify in both groups individuals Infection location Matched median age nucleocapsid paramedic paramedics performed Prospective prospective cohort study risk risk difference SARS-CoV-2 SARS-COV-2 infection Secondary analyses secondary analysis serology testing Seroprevalence Sex specific antibodies subgroup subgroups vaccination Vaccination Status women [DOI] 10.1016/j.annemergmed.2022.03.009 PMC 바로가기 [Article Type] Observational Study
Association of Blood Viscosity With Mortality Among Patients Hospitalized With COVID-19Research article Published on 2022-07-012022-10-05 Journal: Journal of the American College of Cardiology [Category] 바이오마커, [키워드] adjusted age association baseline Blood Blood viscosity calculated cardiovascular disease cardiovascular risk characterized clinically Comorbidities Comorbidity contribute covariate COVID-19 Cox proportional hazard death determine Endothelial dysfunction Estimated evaluate evaluated highest hospitalized COVID-19 patient hospitalized COVID-19 patients immune response in-hospital mortality increase in increases in inflammatory biomarkers lowest Mortality Mount Sinai multivariate objective outcome participant Patient patients hospitalized quartile reducing Result rheology epidemiology Sex significantly Stage study population subgroups System Thrombotic complications viscosity were used with COVID-19 [DOI] 10.1016/j.jacc.2022.04.060 [Article Type] Research article
The validity of self-reported SARS-CoV-2 results among postpartum respondents산후 응답자 중 자가 보고한 SARS-CoV-2 결과의 타당성Article Published on 2022-07-012022-09-11 Journal: Paediatric and perinatal epidemiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] 95% CI Accuracy adjusted Administered age aRR AUC calculated Chain Reaction Characteristics Child development COVID-19 COVID-19 PCR test COVID-19 testing cross-sectional Diagnosis diagnostic Diagnostic accuracy examined gold gold standard Health Health Insurance Hispanic hospital individual majority mechanism medical record New York City obesity obstetrics PCR PCR test PCR testing PCR tests Poisson regression polymerase chain polymerase chain reaction population-based surveys predictor pregnant Rapid recall receipt Research risk risk ratio SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 PCR test SARS-CoV2 SARS-CoV2 PCR testing self-report sensitivity specificity subgroups tested Validity virus women [DOI] 10.1111/ppe.12874 PMC 바로가기 [Article Type] Article
Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID studyObservational Study Published on 2022-07-012022-10-04 Journal: Intensive care medicine [Category] 임상, [키워드] Administered administration affected age Analysis assessment Bacterial baseline benefit Care clinically Corticosteroid corticosteroid treatment Corticosteroids covariate COVID-19 COVID-19 patient Critically ill Critically ill patient Dexamethasone dosage dose doses of corticosteroid early administration Evidence failure higher risk hospitalisation ICU ICU admission ICUs Illness severity in-hospital mortality increased risk Inflammation information intensive care interaction term Invasive mechanical ventilation investigated Laboratory lower risk Major mechanical ventilation Modification Mortality multivariable analysis no effect nosocomial Observational cohort study organ damage Patient patients with COVID-19 performed personalised Pneumonia potential benefit Primary outcome Protective receiving severe coronavirus disease severity Significant SOFA Spanish steroid subgroup subgroups subgroups of patient symptom onset systemic corticosteroid Treatment use of corticosteroid variable with COVID-19 [DOI] 10.1007/s00134-022-06726-w PMC 바로가기 [Article Type] Observational Study
Serological testing for SARS-CoV-2 antibodies in clinical practice: A comparative diagnostic accuracy study임상 실습에서 SARS-CoV-2 항체에 대한 혈청 검사: 비교 진단 정확도 연구Article Published on 2022-07-012022-09-11 Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analytical techniques anti-RBD anti-RBD ELISA Anti-S1 antibody chemiluminescence immunoassay CLIA Clinical practice clinical settings conducted coronavirus coronavirus disease COVID-19 COVID-19 diagnostic testing [Supplementary Concept] defined detect determine diagnostic Diagnostic accuracy diagnostic testing domain electrochemiluminescence immunoassay ELISA enzyme enzyme-linked immunosorbent assays epitope Epitopes health-care host immunity identify IgG immunoassay Infection Infections/*epidemiology/transmission*Disease Outbreaks Infectious disease Infectious diseases Inpatient lateral flow immunoassay likelihood live SARS-CoV-2 measure Nasopharyngeal swab neutralization activity neutralization assays Neutralizing antibodies neutralizing antibody nucleocapsid Patient PCR test performed positive powerful tool Protein RBD Re-infection Real-time PCR Receptor-binding domain respiratory S1/S2 S2 domain SARS-CoV-2 SARS-CoV-2 [Supplementary Concept] SARS-CoV-2 antibodies SARS-CoV-2 antibody sensitivity serological serological test Serological testing Serological tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 [Supplementary Concept] specificity Spike protein subgroup of patient subgroups subtype university [DOI] 10.1111/all.15206 PMC 바로가기 [Article Type] Article
Safety and Immunogenicity of SARS-CoV-2 Vaccines in Patients With Chronic Liver Diseases (CHESS-NMCID 2101): A Multicenter Study만성 간 질환 환자에서 SARS-CoV-2 백신의 안전성 및 면역원성(CHESS-NMCID 2101): 다기관 연구Multicenter Study Published on 2022-07-012022-09-12 Journal: Clinical gastroenterology and hepatology : the off [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome adverse event Adverse reaction Alanine All participant China chronic chronic liver disease Chronic Liver Diseases cirrhosis CLD collected compensated coronavirus defined dose enrolled healthy healthy control healthy volunteer healthy volunteers immunogenicity immunologic response inactivated injection site pain Laboratory testing limit Mild MOST multicenter study Open-label participant Patient positive rate reported Safe Safety SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines second dose serum sample subgroups subject tested Vaccine were recorded whole-virion SARS-CoV-2 vaccine [DOI] 10.1016/j.cgh.2021.12.022 PMC 바로가기 [Article Type] Multicenter Study