Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replicationSARS-CoV-2에 대한 기도 상피 인터페론 반응은 리노바이러스보다 열등하고 이종 라이노바이러스 감염은 SARS-CoV-2 복제를 억제합니다Article Published on 2022-04-282022-09-11 Journal: Scientific Reports [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료제, [키워드] addition AEC airway airway epithelial cell airway epithelial cells airway epithelium alphacoronavirus Betacoronavirus biosafety level Biosafety Level 3 bronchial BSL-3 cell lysate cell lysates children common Concentration correlated Culture cultures CXCL10 Delta delta variant Donor elicit epithelial epithelial cells evade Ex vivo experiment Gene Expression generate greater heterogeneity Heterologous highly pathogenic HRV IFN IFN response IFN-β IFN-λ IFNB1 induce Infection interferon interferon response less level 3 Older omicron Protein recombinant IFN recombinant IFN-β reduce reduced replicated response responses rhinovirus RNA robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly subset supernatant suppresse Treatment type I variant variants viral replication was collected were infected [DOI] 10.1038/s41598-022-10763-2 PMC 바로가기 [Article Type] Article
Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2인간 베타 코로나바이러스 HCoV-OC43 및 SARS-CoV-2에 대한 PAD 억제제의 새로운 항바이러스 활성Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] African green monkey Antiviral antiviral activity Antiviral agents Antiviral compounds beta-coronavirus calcium Cell Citrullination coronavirus COVID-19 patients develop effective Efficacy enzyme Factor family fetal fibroblast green monkey HCoV HCoV-OC43 HCoVs highlight Host-targeting antivirals Infection inhibitor inhibitors inhibitory activity kidney likelihood lung New coronavirus novel OC43 Peptidyl-arginine deiminases Protein rationale Replication repurposing SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication specific inhibitor strain suppresse transcriptional activation Treatment treatment of COVID-19 patients Vero-E6 cells viral replication [DOI] 10.1016/j.antiviral.2022.105278 PMC 바로가기 [Article Type] Article
Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2Nsp1-리보솜 복합체를 표적으로 하는 약물은 SARS-CoV-2에 대한 항바이러스 활성을 나타냅니다Article Published on 2022-03-242022-09-11 Journal: eLife [Category] SARS, 치료제, [키워드] 40S ACE2 antiviral activity appear bind binding affinity binding energy block C-terminal can be used cells complex demonstrated drug Drug administration expressing expression firefly luciferase food form HEK cell help Host host protein immune function in silico in vitro inhibitor inhibitory effect linker Medicine Montelukast MONTELUKAST SODIUM mRNA N-terminal domain non-structural protein nsp1 reduced reporter reporter gene ribosomal subunit ribosome SARS-CoV-2 SARS-COV-2 infection screened sodium sodium hydrate stable complex suppresse Therapeutics translation Vero-E6 cells viral replication viruses [DOI] 10.7554/eLife.74877 PMC 바로가기 [Article Type] Article
A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold clusterResearch article Published on 2022-03-212022-10-05 Journal: Nano Today [Category] 신약개발, [키워드] approved arthritis treatment bind cells Cluster COVID-19 crystal Cys145 decrease down-regulate expression Gold cluster hamster hamsters in vivo Inflammatory Inflammatory cytokine inhibiting Injury intrinsic intrinsically lung mice NFκB outcome pathway patients reduce released reveal Rheumatoid SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 viral replication significantly significantly lower suppresse therapeutic transgenic mice treated Treatment viral replication while [DOI] 10.1016/j.nantod.2022.101468 [Article Type] Research article
AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMCResearch Published on 2022-03-032022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] activate activated Activation acute respiratory syndrome addition agonist AhR AMP5A And Chemokines antagonist antiviral immunity Aryl hydrocarbon receptor Autoimmunity biologic chemokines clinical investigation condition coronavirus coronavirus disease Course COVID-19 CXCL10 cytokine Cytokines decrease detect differentially expressed dysregulated Effect ELISA enrichment analysis evaluate experiment fraction Human serum albumin hyperinflammation Hyperinflammatory IL-12 IL-1β IL-6 Imbalance Immune cell immune response immunomodulatory implicated Infection Inflammation inflammatory mediator Inflammatory response inhibit Intervention involved low molecular weight Lung disease mechanism modulate mononuclear cells myeloid cell myeloid cells NF-κB NF-κB activation Osteoarthritis pathway PBMC Peripheral blood PPARγ pro-inflammatory pro-inflammatory cytokine profiles progression Protective provided receptor REP Result resulting RNA Severe case Signaling single-stranded ssRNA suppresse Therapeutic approach THP-1 TLR TLR7 TLR7/8 Toll-like receptor toll-like receptor 7 Toll-like receptor 8 transcription factor transcription factors treat Treatment viral sequences were used with COVID-19 [DOI] 10.1186/s41231-022-00110-y PMC 바로가기 [Article Type] Research
Potential Inhibitors Targeting Papain-Like Protease of SARS-CoV-2: Two Birds With One StoneChemistry Published on 2022-02-232022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] acute respiratory syndrome Administered Antiviral antiviral immunity approach approved Bird Community COVID-19 crystal structure Efficacy and safety feature functional Health Host Infection inhibition inhibitor inhibitors innate immune response International Intervention mutate outbreak Papain-like protease pathogen PLPro Potential Prevent protease resulting SARS-CoV-2 Spread Stone Support suppresse targeting the patient Vaccine viral replication virus [DOI] 10.3389/fchem.2022.822785 PMC 바로가기 [Article Type] Chemistry
ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variantsACE2-표적화 항체는 SARS-CoV-2 오미크론 및 델타 변이체를 억제합니다Letter Published on 2022-02-092022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibody Cell Biology delta variant Infection omicron SARS-CoV-2 suppresse [DOI] 10.1038/s41392-022-00913-3 PMC 바로가기 [Article Type] Letter
Naltrexone a potential therapeutic candidate for COVID-19Article Published on 2022-02-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 approved binding bioinformatics clinical coronavirus 2 Coronavirus infection COVID-19 COVID-19 patients Cytokines storm disrupt docking downstream Drug repurposing global pandemic glycoprotein host cells host receptor Hyperinflammatory induce inhibit inhibitor Interaction interfere Like lung tissue macrophage cell molecular molecular docking multiple organ failure naltrexone other coronaviruses Phosphorylation positively correlated pro-inflammatory cytokine pro-inflammatory cytokine release pro-inflammatory cytokine storm Protein RBD reported required respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection spike structural bioinformatics suppresse suppressed surface Spike tested the SARS-CoV-2 therapeutic therapy Toxicity Treatment viral entry viral infectivity viral replication virus load [DOI] 10.1080/07391102.2020.1820379 PMC 바로가기 [Article Type] Article
Elimination of Aicardi–Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replicationAicardi-Goutières 증후군 단백질 SAMHD1 제거는 세포 선천 면역을 활성화하고 SARS-CoV-2 복제를 억제합니다Research Article Published on 2022-01-252022-09-10 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 치료제, [키워드] 293T ACE2, angiotensin-converting enzyme 2 activate activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect AGS, Aicardi–Goutières syndrome Antiviral ARHGEF5, Rho guanine nucleotide exchange factor 5 Baricitinib cDNA, complementary DNA Cell cell lines cells cellular characterized clearance coronavirus COVID-19, Coronavirus disease 2019 CRISPR Culture Degradation demonstrated DMEM, Dulbecco's modified Eagle's medium downregulated elevated Elimination expression FBS, fetal bovine serum FDA, US Food and Drug Administration Gene Expression Genetic HCoV-OC43, human coronavirus OC43 human coronavirus human coronavirus OC43 IFN IFN signaling IFN, interferon IFNs immune responses Infection innate immune response Innate immunity interferon interferons interferons (IFNs) IRF3, IFN regulatory factor 3 ISG, IFN-stimulated gene JAK inhibitor JAK pathway JAK, Janus kinase lack lentiviral Macrophage macrophages MDM, monocyte-derived macrophage model system MOI, multiplicity of infection Monocyte-derived macrophages mRNA NSP, nonstructural protein Pathways Phosphorylation Protein protein expression pSTAT1, phosphorylated form of STAT1 qRT–PCR, quantitative RT–PCR regulate Replication respiratory SAMHD1 SAMHD1, sterile alpha motif and histidine–aspartate domain–containing protein 1 SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2–infected patient SARS-CoV-2–infected patients SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown Signaling signaling pathway significantly increased Stat1 STAT1, signal transducer and activator of transcription 1 suppresse suppressed syndrome THP-1 tissue tissue culture Treatment upregulated Viral Viral protein Virus-like particle virus-like particles VLP, virus-like particle Vpx, viral protein X [DOI] 10.1016/j.jbc.2022.101635 PMC 바로가기 [Article Type] Research Article
Activation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cellsResearch Published on 2022-01-182022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] activate Activation acute respiratory syndrome caused Cell cellular coronavirus coronavirus disease COVID-19 Efficacy endogenous Fatty acid fatty acids Glutamine Glycolysis Host Infection inhibitor Intervention introduced investigated metabolism metabolite MHV Mitochondria mitochondrial metabolism mouse hepatitis mouse hepatitis virus NAD+ nicotinamide riboside NR pandemic pyruvate Replication reported Result SARS-CoV-2 significantly supplementary material suppress suppresse suppressed survival TCA cycle therapeutic Therapeutic molecule therapy for COVID-19 Transport viral replication virus virus-infected cell [DOI] 10.1186/s13578-021-00740-z PMC 바로가기 [Article Type] Research