suppression – Page 2 – Communicable Diseases Research

The Translational Landscape of SARS-CoV-2-infected Cells Reveals Suppression of Innate Immune Genes

SARS-CoV-2에 감염된 세포의 번역 환경은 선천 면역 유전자의 억제를 나타냅니다

Article

Published on 2022-06-282022-09-11
Journal: mBio [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 Secretion

IFN-β 및 IL-6 분비를 효율적으로 억제하기 위해 SARS-CoV-2 ORF6 단백질에 의해 핵공 이동이 방해됨

Article

Published on 2022-06-112022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation addition antagonistic antiviral response block cascade characterized clinical outcomes contributing to counteract Critical cytokine Cytokines cytoplasm cytoplasmic demonstrated ENCODE exacerbated Factors feature Genes Host host immune system IFN-β IL-6 immune immune evasion Infection Inflammation interferon interferon antagonist interleukin interleukin-6 MAVS MDA-5 mechanism Messenger RNA movement mRNA multifunctional NF-κB not affected novel SARS-CoV-2 virus nuclear translocation nucleus occurred ORF6 pro-inflammatory cytokine pro-inflammatory cytokines Protein reported RIG-I SARS-CoV-2 SARS-CoV-2 ORF6 protein SARS-CoV-2 virus Signaling STAT suppresse suppression the SARS-CoV-2 Traffic transcription factor transcription factors transcriptional viral infection viral pathogenesis virulence virus
[DOI] 10.3390/v14061273 PMC 바로가기 [Article Type] Article

A New Compartment Model of COVID-19 Transmission: The Broken-Link Model

COVID-19 전파의 새로운 구획 모델: 끊어진 연결 모델

Article

Published on 2022-06-032022-09-11
Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종,

Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogramming

IRAK4의 억제는 SARS-CoV-2 스파이크 단백질 유도 대식세포 염증 및 해당과정 재프로그래밍을 조절하지 못함

Article

Published on 2022-05-192022-09-11
Journal: Cellular and Molecular Life Sciences [Category] Coronavirus, COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE2 activate AKT baseline blockade CCL2 cells citrate counteract Critical dysregulated ERK expression Glycolysis human SARS-CoV-2 Hyperactivation IL-6 IL-8 impair independent Inflammatory Inflammatory marker inflammatory markers inhibition inhibitor Innate immunity irak4 IRAK4 inhibitor IRF5 IRF7 knockdown Lactate LDHA Macrophage macrophages metabolic activity mitochondrial Mitochondrial oxidative phosphorylation molecular mechanism monokines murine models NF-κB NF-κB activation oxidative oxidative phosphorylation phenotype Phosphorylation promoted Protein reduction response responsible reversal SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 patient severe COVID-19 patients shown Signaling siRNA spike Spike protein succinate suppression Therapeutic strategies therapy TLR TLR-mediated TLR2 TLR7 TLRs TNFα treated Treatment triggered without affecting
[DOI] 10.1007/s00018-022-04329-8 PMC 바로가기 [Article Type] Article

Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants

스트레인 워즈 2: 결합 상수, 엔탈피, 엔트로피, 깁스 에너지 및 SARS-CoV-2 변이체의 결합 속도

Article

Published on 2022-05-012022-09-11
Journal: Virology [Category] COVID19(2023년), SARS, 변종,

Effect of Androgen Suppression on Clinical Outcomes in Hospitalized Men With COVID-19: The HITCH Randomized Clinical Trial

Randomized Controlled Trial

Published on 2022-04-012022-10-04
Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 임상,

[키워드] adverse event Affair age all-cause mortality analyzed androgen antiandrogen Antibiotics Asthma baseline cardiovascular disease Care Cell chronic obstructive chronic respiratory clinical Clinical improvement Clinical outcome common Comorbidity convalescent plasma COVID-19 COVID-19 severity Department determine Dexamethasone diabete disease severity disorder double-blind Effect Efficacy end point End points enrolled Hemodialysis hospital Hospitalization Hospitalized hypertension IMPROVE Inpatient interim analysis intravenous fluids Invasive mechanical ventilation mechanical ventilation median men Mortality no difference no significant difference outcome Patient patients patients randomized Peritoneal dialysis Placebo placebo group placebo-controlled primary end point protease randomization Randomized randomized clinical trial reduce expression Remdesivir requiring supplemental oxygen saline placebo SARS-CoV-2 entry secondary Serious Adverse Event severity of COVID-19 Standard standard care stratified subcutaneous dose supplemental oxygen suppression temperature the placebo group therapy TMPRSS2 Trial usual care vasopressor support veteran with COVID-19
[DOI] 10.1001/jamanetworkopen.2022.7852 PMC 바로가기 [Article Type] Randomized Controlled Trial

The anti-C5a antibody vilobelimab efficiently inhibits C5a in patients with severe COVID-19

항-C5a 항체 빌로벨리맙은 중증 COVID-19 환자에서 C5a를 효율적으로 억제합니다

Article

Published on 2022-04-012022-09-11
Journal: Clinical and translational science [Category] 임상, 진단,

[키워드] 1:1 Activation adaptive Analysis anaphylatoxin C5a antibody assigned benefit best Blood C3a C5a cause Chain Reaction Coagulation Coagulation system Concentration control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia demonstrated drug concentration enzyme favor geometric geometric mean IFX-1 Infection infection site inhibit IQR leads median monoclonal antibody monocyte Monocytes neutrophil Neutrophils oxidative Patient plasma polymerase chain polymerase chain reaction Randomly ranged real-time polymerase chain reaction receive releases reported Result Safe Sample secondary outcome severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia supportive care suppressed suppression tissue damage Trial vilobelimab
[DOI] 10.1111/cts.13213 PMC 바로가기 [Article Type] Article

Targeting the Interaction Between Spike Protein and Nucleocapsid Protein for Suppression and Detection of Human Coronavirus OC43

인간 코로나바이러스 OC43의 억제 및 검출을 위한 스파이크 단백질과 뉴클레오캡시드 단백질 간의 상호작용 표적화

Article

Published on 2022-03-102022-09-11
Journal: Frontiers in Immunology [Category] SARS, 변종, 치료기술, 치료법, 치료제,

[키워드] anti-HCoV-OC43 anti-HCoV-OC43 N antibody bait and prey C-terminal domain Cell colds conserved coronavirus detect detection ELISA fusion protein HCoV HCoV-OC43 Human human coronavirus human coronavirus OC43 in vitro Infection inhibit interact Interaction investigated MERS MERS-CoV monoclonal antibody N protein N proteins Novel coronavirus nucleocapsid nucleocapsid protein OC43 Penetrating peptide prey producing Protein protein expression Replication replication of SARS-CoV-2 reported S protein SARS-CoV-2 spike Spike protein suppression target targeting the S protein Therapeutics upper respiratory tract variants virus virus detection
[DOI] 10.3389/fimmu.2022.835333 PMC 바로가기 [Article Type] Article

Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis

폐 섬유증에서 폐포 상피 줄기 세포 노화 및 노화 관련 분화 장애의 분자 기전

Review

Published on 2022-03-032022-09-11
Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] accelerated alveolar caused Cell cell senescence cellular senescence COVID-19 Degradation developmental differentiation disorder disrupt DNA damage DNA damage response dysfunction epithelial fibrosis followed by framework Idiopathic pulmonary fibrosis induce inhibiting inhibitor Intervention IPF low-grade inflammation mechanism molecular mechanism molecular mechanisms OIS oncogene pathway Premature Protein pulmonary pulmonary fibrosis replicative replicative senescence reported reverse transcriptase RNA SARS-CoV-2 viral infection senescence senescent cell senescent cells STEM stem cell suppression susceptibility telomerase telomerase and telomeres. telomeres TERC TERT TGF TGF-β TGF-β signalling TPP1 transcriptase Viral viral infection
[DOI] 10.3390/cells11050877 PMC 바로가기 [Article Type] Review

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Review

Published on 2022-01-142022-10-30
Journal: International Journal of Environmental Research an [Category] COVID-19, SARS,