Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based IsolationReview Published on 2021-11-262022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] adhesion Affect affecting Anti-inflammatory anticancer Biomolecule biosensors CAM can be used Cell Cell adhesion cellular classical Compound concerning Effect Effects Evidence experiment faster fungi Gene Expression greater Health highlighting integrin Isolation knowledge mechanism metabolite metabolites Migration movement natural natural compound plant plants preparation quantification SARS-CoV-2 SARS-CoV-2 treatment signaling pathway Stimulation surface receptor target viability virus [DOI] 10.3390/biomedicines9121781 PMC 바로가기 [Article Type] Review
COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and PharmacotherapyEndocrinology Published on 2021-11-192022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) angiotensin Anticoagulants CD147 Clinical management comorbid patient Comprehensive COVID - 19 COVID-19 COVID-19 susceptibility DC-SIGN diabete Diabetes Mellitus diabetic patient DPP4 drugs Effect Efficacy evaluated form Gender glucocorticoid implication inhibitors Interaction knowledge L-SIGN mACE2 patients with COVID-19 Perspective pharmacotherapy positive receptor review risk sACE2 SARS- CoV-2 SARS-COV-2 infection severity surface receptor therapeutic management Treatment viral cell [DOI] 10.3389/fendo.2021.772865 PMC 바로가기 [Article Type] Endocrinology
A Bacterial Cell-Based Assay To Study SARS-CoV-2 Protein-Protein InteractionsResearch Article Published on 2021-11-162022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome amino acid substitution Bacterial Cell circulating SARS-CoV-2 variants coronavirus coronavirus disease COVID-19 cytoplasm detect disrupt dissect domain Effect encoded protein encoded proteins Escherichia coli eukaryotic examined facilitate feasibility Genetic Health Interaction interactions mutations PPI Protein protein interactome protein-protein interaction protein-protein interactions Proteins proteome RBD RBD-ACE2 reducing SARS-CoV-2 Spike protein surface receptor the SARS-CoV-2 therapeutic this system Treatment two-hybrid analyses utility Viral protein [DOI] 10.1128/mBio.02936-21 PMC 바로가기 [Article Type] Research Article
Pulmonary vascular system: A vulnerable target for COVID‐19Review Published on 2021-10-172022-10-30 Journal: MedComm [Category] COVID-19, [키워드] acute respiratory syndrome binding caused change clinical presentation clinician coagulation cascade Coagulopathy Community coronavirus coronavirus disease COVID‐19 COVID‐19 direct infection Diseases dysfunction Effect endothelial Endothelial cell endothelial damage endotheliopathy entry receptor enzyme expressed global pandemic hallmark healthcare hosts immune dysregulation Infection Inflammation Intussusceptive angiogenesis occur oxidative stress pathologic pathophysiology Potential treatment pulmonary pulmonary vascular system recent reported SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 significantly surface receptor susceptible the disease therapeutic strategy thrombosis Vascular vascular endothelial damage Vascular injury vasculature [DOI] 10.1002/mco2.94 PMC 바로가기 [Article Type] Review
Targeting virus-host interaction by novel pyrimidine derivative: an in silico approach towards discovery of potential drug against COVID-19새로운 피리 미딘 유도체에 의한 바이러스-호스트 상호 작용 표적 : Covid-19에 대한 잠재적 약물의 발견을 향한 실리코 접근법Article Published on 2021-09-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] abundantly expressed acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analogue angiotensin angiotensin-converting enzyme-2 appear applied bind binding binding free energy binding free energy calculation binding site Cell cell surface receptor cell tropism characterized complex condition coronavirus coronavirus disease coronavirus disease-2019 COVID-19 derivative disrupt drug candidate drug target effective inhibitor free energy globe group hACE2 host cell host cells human Angiotensin-converting enzyme human population identify in silico Approach in vitro in vivo Infection inhibitor Interaction interface internalization lung tissues molecular molecular docking molecular dynamics molecules Pathogenesis phenol primary determinant pyrimidine pyrimidine derivatives receptor respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus spike glycoprotein Spread surface receptor targeting therapeutic virion virus virus entry [DOI] 10.1080/07391102.2020.1794969 PMC 바로가기 [Article Type] Article
Designing Short Peptides to Block the Interaction of SARS-CoV-2 and Human ACE2 for COVID-19 TherapeuticsPharmacology Published on 2021-08-272022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 affinity Amino acid binding binding affinity binding interaction block caused Cell complex conserved COVID-19 COVID-19 pandemic de novo designed peptide develop domain drugs expressed Human human Angiotensin-converting enzyme human cell Interaction molecular much higher peptide RBD receptor Region reported required residue S glycoprotein SARS-CoV-2 selected significantly higher spike glycoprotein surface receptor the binding affinity the RBD Therapeutics Treatment virus [DOI] 10.3389/fphar.2021.731828 PMC 바로가기 [Article Type] Pharmacology
“Molecular Masks” for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus EntrySARS-CoV-2 바이러스 진입을 효과적이고 안전하게 차단하는 ACE2용 "분자 마스크"Article Published on 2021-08-202022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 applicability block blocked blood pressure cause Cell cell surface receptor Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D614G decrease derivative dimeric enzyme enzyme activity Health Health crisis Human human body human cell human cells Infection Interaction mutant normal blood pressure peptoids pseudovirus Regulation respiratory resulting Safe SARS-CoV-2 SARS-CoV-2 pseudovirus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein surface receptor these compound these compounds unique Vaccine virus [DOI] 10.3390/ijms22168963 PMC 바로가기 [Article Type] Article
The glomerular filtration barrier: a structural target for novel kidney therapies Reviews Published on 2021-07-142022-10-05 Journal: Nature Reviews Drug Discovery [Category] 바이오마커, [키워드] Affect APOL1 Cell cells characterized component contractile contribute CoQ10 disease diuretics endothelial experiment genetics glomerular filtration growth factor homologue Immunosuppressive agents include inhibitor Intercellular communication intervene kidney Kidney disease Kidney function Loss maintain Mitochondrial function molecular target morbidity and mortality MOST podocyte question receptor review ROBO2 suPAR surface receptor therapy treated tyrosine Vascular [DOI] 10.1038/s41573-021-00242-0 [Article Type] Reviews
Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 PathologiesCOVID-19 병리학에서 팔미트산 증대의 분자 메커니즘Article Published on 2021-07-012022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] ACE2 Activation Affect affected apoptotic attenuate augmentation base Biological biological molecules canonical CCL2 CCL5 Cell cell surface receptor chemokines claimed coronavirus disease Coronavirus disease 2019 coronavirus pathogenesis COVID-19 COVID-19 pathology Cytokines dataset EEF1A1 elevated exacerbate expression Fatty acid fatty acids FFA FFAs free fatty acid free fatty acids IL1β Inflammatory mediators Ingenuity Pathway Analysis inhibiting knowledge base modulate molecular mechanism molecular mechanisms Mortality n-3 fatty acid NFκB obese obesity palmitic acid pandemic Pathologies pathway progression PTGS2 retrieved SARS-CoV-2 spike protein severity Spike protein subjects surface receptor the SARS-CoV-2 transcription factors translation were used [DOI] 10.3390/ijms22137127 PMC 바로가기 [Article Type] Article
Imatinib (STI571) Inhibits the Expression of Angiotensin-Converting Enzyme 2 and Cell Entry of the SARS-CoV-2-Derived Pseudotyped Viral ParticlesArticle Published on 2021-06-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 gene angiotensin-converting enzyme 2 approved Cancer Care Cell Cell culture cell entry clinically combined treatment COVID-19 COVID-19 infection Effect expression Imatinib Imatinib (STI571 inhibit inhibitor intestine kinase lung mice other organ Particle protein levels pseudoparticle receptor renal SARS-CoV-2 screened STI571 surface receptor therapeutic therapeutic target tissue expression transcript tyrosine tyrosine kinase tyrosine kinase inhibitor was reduced [DOI] 10.3390/ijms22136938 PMC 바로가기 [Article Type] Article