Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approachArticle Published on 2022-09-012022-11-15 Journal: Microbial pathogenesis [Category] SARS, 유전자 메커니즘, 치료제, [키워드] addition African Analysis Antiviral compound antiviral target approach binding energy calculate Cell cellular entry characterized Compound conformational database demonstrated disrupt distribution expressed feature functional In-vitro inhibitory effect Interaction mechanism of action molecular molecular dynamic simulation Molecular dynamics simulation multiple organ natural natural product Neuropilin-1 NRP1 performed pleiotropic Protein recent S-protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 research screened selected South stability surface receptor the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach viral infectivity Virtual screening [DOI] 10.1016/j.micpath.2022.105701 PMC 바로가기
Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike ProteinArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ADAM10 addition bind Cell cell death cell interaction cleavage cleaved complex condition contributed coronavirus SARS-CoV COVID-19 develop domain effective element endosomal pathway entry pathway evade furin furin cleavage motif highly pathogenic Host host protease human coronaviruses identify Immunity independent Infection infection mechanism inhibitor involved membrane membrane fusion metalloproteinase organ damage Pathogenesis pathogenesis of COVID-19 pathway Prevent priming provide required S1/S2 boundary S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selective sequence siRNAs Site spike Spread surface surface receptor syncytium formation the spike protein therapeutic agent therapeutic target Therapies TMPRSS2 unique vaccination variants virus entry virus variant [DOI] 10.1128/mbio.00519-22 PMC 바로가기
Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 DiseaseCOVID-19 질병에서 SARS-CoV-2 상호작용 MicroRNA의 전사체 영향에 대한 유전자 네트워크 분석Review Published on 2022-08-172022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] affected Analysis biochemical biological processes Cell cell cycle cell surface receptor changes characterized COVID-19 COVID-19 disease cytokine death DEGs differentially expressed differentially expressed gene Differentially expressed genes downregulated exploratory FIVE functional enrichment Functional enrichment analysis Gene Expression gene network Health Organization heart Impact involved kidneys list lung Lymph node microRNA MicroRNAs mitochondrial mitotic mitotic cell modulation molecular Multiorgan multiorgan disease network network analysis pathological mechanism Pathways Perspective predicted provide reported SARS-CoV-2 SARS-CoV-2 virus signaling pathway submitted surface receptor target tissue tissues transcriptomes translated upregulated WHO with COVID-19 World Health Organization [DOI] 10.3390/ijms23169239 PMC 바로가기 [Article Type] Review
Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses [DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article
Bovine colostrum-derived antibodies against SARS-CoV-2 show great potential to serve as prophylactic agentsSARS-CoV-2에 대한 소 초유 유래 항체는 예방제 역할을 할 수 있는 큰 잠재력을 보여줍니다Article Published on 2022-06-102022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome Administered angiotensin-converting enzyme 2 antibody block Blood boost Cell Characteristics clinical study colostrum coronavirus cow defined health system immunization immunized Immunoglobulin in vitro assays Interaction mechanism NAb NAbs nasal nasal mucosa neutralizing antibody other disease presenting Prophylactic prophylactic treatment Protein purified RBD Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 social distancing Spread subjects surface receptor trimeric S protein vaccination virus virus entry wearing masks [DOI] 10.1371/journal.pone.0268806 PMC 바로가기 [Article Type] Article
Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine범사르베코바이러스 수지상세포 표적화 백신의 설계, 면역원성 및 효능Article Published on 2022-06-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Antigen antigens antiviral efficacy B-cell epitope B-cell epitopes BNT162b2 CD40 conserved Coronaviruses COVID-19 cross-neutralizing antibodies cross-neutralizing antibody cross-reactive demonstrated dendritic cells Efficacy elicited ENhance Epitopes framework functional hACE2 homologous immunization immunogenic immunogenicity in vitro initiative K18-hACE2 transgenic mice Medicine MERS mice mRNA BNT162b2 vaccine Mutation Neutralizing antibodies nucleocapsid potency Pre-clinical model protein subunit vaccine recall Sarbecoviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S spike Subunit vaccine supported surface receptor survival T-cell Response T-cell responses Vaccine variants of concern Viral viral control VoC VOCs [DOI] 10.1016/j.ebiom.2022.104062 PMC 바로가기 [Article Type] Article
E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutritionReview article Published on 2022-02-012022-10-05 Journal: Seminars in Immunology [Category] 임상, [키워드] absorbance activate activating Acute inflammation acute inflammatory response adaptive apoptotic cells approach B-cells biosynthesized blood clot caused cellular response clinical study clinical trials Complete COVID-19 COVID-19 infection COVID-19 pandemic Critical defined disease Disease model docosahexaenoic acid (DHA) Eicosapentaenoic acid (EPA) EPA essential fatty acid Evidence excessive inflammation Fatty acid function functional Health homeostasis human clinical trials Human phagocytes human tissue Immune cell Inflammation Inflammatory innate immune cell Interaction International Ligand local inflammation loci lymphocyte M2 macrophages Macrophage Maresin mechanism mechanisms metabolome MS2 Neutrophils omega-3 Omega-3 polyunsaturated fatty acids organ Pathogens phagocyte physical Precision precursor Preparing Protective raised required Resolvin Specific stem cell stimulate Structure structures subset surface receptor T-cell Tandem mass spectrometry tissue regeneration unique [DOI] 10.1016/j.smim.2022.101597 [Article Type] Review article
SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry423 Published on 2022-01-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome analyses binding C terminal Cell cell entry cell surface pathway complex coronavirus cytosolic demonstrated domain endocytic Endocytic pathway enzyme functional fusing homeostasis host cell inhibiting Interaction Invasion membrane fusion motif physiological conditions plasma membrane Prevent Protein RBD recent regulate Regulation resulting retromer SARS coronaviruses SARS-CoV-2 SARS-COV-2 infection Significance SNX27 suppresse surface receptor therapeutic target type I viral entry virus was used [DOI] 10.1073/pnas.2117576119 PMC 바로가기 [Article Type] 423
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19Research Article Published on 2022-01-102022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] abrogated Anti-inflammatory therapy anti-inflammatory treatment autocrine Bacterial Bacterial infection bacterial superinfection bacterial superinfections caused CD11b CD163 CD66b CD86 Cell cellular characterized classical Clusters complicate Course COVID-19 COVID-19 patient COVID-19 patients Critically ill CRP CXCR1 CXCR2 CXCR4 cytokine cytokine levels cytokine signaling Dexamethasone disease severity driven by dysregulated dysregulation elevated Ex vivo exacerbate exhibited expression function functional HLA-DR host response host-response hypercytokinemia Hyperinflammatory ICU IFN-γ IL-4 IL-6 level Immune cell immune cells immune response IMPROVE increased mortality induce Inflammatory marker inflammatory mediator Inflammatory mediators innate immune function Innate immunity low expression monocyte Monocytes MPO myeloid cell NET neutrophil paracrine paralysis patients phenotype phenotypic plasma provide receiving reduced reduction reduction in reflected response ROS production SARS-CoV-2 SARS-CoV-2 pathogenesis subsequent suppressed surface receptor Symptom synergistic systemic inflammation the disease TNF-α treated utility [DOI] 10.1371/journal.ppat.1010176 PMC 바로가기 [Article Type] Research Article
Antibody response to COVID-19 vaccine: A point of view that can help to optimize dose distributionCOVID-19 백신에 대한 항체 반응: 용량 분포를 최적화하는 데 도움이 될 수 있는 관점Observational Study Published on 2022-01-012022-09-12 Journal: International immunopharmacology [Category] MERS, SARS, 임상, 진단, [키워드] ACE2 anti-SARS-CoV-2 antibody assays Asymptomatic cellular collected coronavirus disease COVID-19 COVID-19 vaccines distribution dose enzyme help hospital IgG antibody individual individuals Infection information Interaction magnitude management Mindray natural infection neutralizing antibody produced protective immune response RBD Rome same order SARS-COV-2 infection second dose serum sample single dose Surface glycoprotein surface receptor the vaccine university vaccination Vaccine Virus spike were measured worker [DOI] 10.1016/j.intimp.2021.108406 PMC 바로가기 [Article Type] Observational Study