Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19비 이온 성 계면 활성제의 실현 가능성을 면밀히 조사하여 커큐민의 등방성 비 셀을 형성 : Covid-19에 대한 잠재적 인 항 바이러스 후보Research Article Published on 2021-12-292022-09-10 Journal: AAPS PharmSciTech [Category] 치료제, [키워드] Against antiviral activity antiviral therapy benefit Bicelles candidate Clinical studies clinical study conditions COVID-19 COVID-19 patients cremophor EL Curcumin docking drug delivery system ENhance Ex vivo exhibited form hydrophobic drug investigated Liposome mechanism Mixed micelles molecular docking Non-ionic surfactants permeation Phosphatidylcholine Potential SARS-CoV-2 significantly surfactant TEM therapeutic tween was used [DOI] 10.1208/s12249-021-02197-2 PMC 바로가기 [Article Type] Research Article
Channels and Transporters of the Pulmonary Lamellar Body in Health and DiseaseReview Published on 2021-12-242022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] acidic pH Alveolar Type II alveolus ambroxol ATII ATP Cell channel clearance complex deficiency disease distress Exocytosis expressed form function innate immune system Ivermectin lack Lamellar Body Ligand Lipid lung lysosome related organelle (LRO) maintain membrane organelle organism Pathogens pathway Proteins pulmonary purinergic signaling receptors reduction responsible SARS-CoV-2 secretion surfactant syndrome tension therapeutic targets transporter viral infection [DOI] 10.3390/cells11010045 PMC 바로가기 [Article Type] Review
Sophorolipid: a glycolipid biosurfactant as a potential therapeutic agent against COVID-19Sophorolipid : COVID-19에 대한 잠재적 치료제로서의 glycolipid bioswermantantReview Published on 2021-12-142022-09-10 Journal: Bioengineered [Category] 신약개발, 치료제, [키워드] addition anticancer Antiviral antiviral activity antiviral therapy attenuate being biosurfactant Cancer candidate caused COVID-19 COVID-19 in patients COVID-19 patient COVID-19 patients cytokine Cytokine storm effective glycolipids immune response immunomodulation immunomodulator Infection inhibit Interfacial tension microorganisms modulate nonpathogenic produced progression reduction in Research SARS-CoV-2 selected shown sophorolipid sophorolipids surfactant tension the cytokine storm the SARS-CoV-2 therapeutic therapeutic agent Treatment treatment of COVID-19 unique variety Viral diseases viruses [DOI] 10.1080/21655979.2021.1997261 PMC 바로가기 [Article Type] Review
Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial심각한 COVID-19 감염에서 계면 활성제 분무 후 빠른 인지질 회전율 : 무작위 임상 시험Randomized Controlled Trial Published on 2021-12-072022-08-13 Journal: American Journal of Respiratory and Critical Care [Category] MERS, 바이오마커, 임상, [키워드] clinical COVID-19 nebulization phospholipid Rapid surfactant turnover [DOI] 10.1164/rccm.202110-2279LE PMC 바로가기 [Article Type] Randomized Controlled Trial
A case of xenon inhalation therapy for respiratory failure and neuropsychiatric disorders associated with COVID-19Case Report Published on 2021-10-282022-10-31 Journal: EXCLI Journal [Category] COVID-19, [키워드] alveolar applied approach ARDS biochemical Blood Case report caused change clinical study Computed tomography Coronavirus pneumonia COVID-19 demonstrated develop disorder disrupt distress effective Effectiveness Efficacy evaluated feasibility functional Gas exchange hematological increase Inhaled Intensive Interaction lung Lungs mechanism of action molecular Molecular modeling Neuropsychiatric neuropsychiatric disorders oxygen saturation parameters Patient patients with pneumonia phospholipid Respiratory failure SARS-CoV-2 SARS-COV-2 infection saturated surfactant syndrome tension therapeutic therapy transferred Treatment van der Waal Ventilation with COVID-19 xenon xenon atom [DOI] 10.17179/excli2021-4316 PMC 바로가기 [Article Type] Case Report
Potential Therapeutic Applications of Pulmonary Surfactant Lipids in the Host Defence Against Respiratory Viral Infections호흡기 바이러스 감염에 대한 숙주 방어에서 폐 계면활성제 지질의 잠재적 치료 응용Review Published on 2021-09-272022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] Against alveolar alveolar epithelium Antiviral effect antiviral effects antiviral properties application ARDS breathing complex COVID-19 Defense facilitate Host host defense immune responses in some Inflammatory response Lipid lipids Lungs modify modulate phosphatidylglycerol phosphatidylinositol Potential promise Protein protein A Proteins pulmonary Pulmonary Surfactant pulmonary surfactant lipids reducing required respiratory respiratory viral infections shown surface tension surfactant tension therapeutic therapeutic applications Viral [DOI] 10.3389/fimmu.2021.730022 PMC 바로가기 [Article Type] Review
Pattern Recognition Proteins: First Line of Defense Against CoronavirusesImmunology Published on 2021-09-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress syndrome adaptive Adaptive immune response Affect affecting Against apoptotic cell ATH - atherosclerosis atherosclerotic lesions C-reactive protein C1q cardiovascular complication cardiovascular system caused clearance combination treatment complement Complication composed coronavirus Coronaviruses COVID- 19 COVID-19 COVID-19 disease death development Direct Effect enhancement global healthcare host’s immune system IgM antibodies immune Immunity Innate innate and adaptive IgM antibodies Innate immunity involved killing LINE lung novel coronavirus SARS-CoV-2 outbreak pandemic patients with SARS-CoV-2 pattern pattern recognition proteins Prevent Prophylactic Protein Recognition recognition protein reduce RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 virus severe disease severe respiratory syndrome surfactant surfactant proteins A and D (SP-A and SP-D) the SARS-CoV-2 Therapeutic approach therapy Vaccine viral particle virus worldwide pandemic Wuhan, China [DOI] 10.3389/fimmu.2021.652252 PMC 바로가기 [Article Type] Immunology
Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2전장 재조합 HSP-D는 SARS-COV-2를 결합하고 억제한다Article Published on 2021-07-282022-09-10 Journal: Biomolecules [Category] Coronavirus, SARS, 변종, [키워드] ACE2 aggregation Anti-inflammatory Anti-viral bind binding binding assay Binding assays bronchoalveolar lavage sample bronchoalveolar lavage samples Caco-2 Caco-2 cell Caco-2 cells cells clearance Combined Concentration COVID-19 COVID-19 patient COVID-19 patients Critical driven by ELISA ELISAs epithelial evaluated facilitate followed by gel electrophoresis glycosylated healthy control healthy controls host cell host cells immune defense immune response in vitro induce inhibit initiate invading pathogen invading pathogens lung lung type II pneumocytes Lungs median member Pathogens Patient performed potential therapy Protein pulmonary recognize recombinant Replication reported Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication silver SP-D spike-protein staining Structure surfactant the SARS-CoV-2 type II pneumocytes variants Viral viral replication virus Virus Disease virus replication viruses were measured [DOI] 10.3390/biom11081114 PMC 바로가기 [Article Type] Article
Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severitySARS-CoV-2에 감염된 햄스터 폐 조직의 정량적 단백질체학은 질병 발병기전 및 중증도에 영향을 미치는 숙주 인자를 나타냅니다Article Published on 2021-07-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] SARS, 유전자 메커니즘, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar damage Analysis carried clinical parameter Clinical parameters coagulation cascade complement convalescence coronavirus COVID-19 COVID-19 patient COVID-19 patients DAD differential expression differentially expressed differentially expressed proteins Diffuse alveolar damage effort enriched pathways evaluate expression Factor Ferroptosis groups hamster hamsters histopathological Host in vivo infected with SARS-CoV-2 involved isolates Local lung Lung function Lung pathology lung proteome lung tissue lung tissues mass spectrometry Mesocricetus Orbitrap Pathogenesis pathological change pathophysiological Pathway analysis platelet activation Post-infection progression protective role Protein proteomic proteomics Pulmonary Surfactant Quantitative reported resolved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2-infected hamster SARS-CoV-2-infected hamsters severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity SFTPB SFTPD significantly surfactant Syrian golden hamster Syrian Golden hamsters the disease tissue sample tissue samples [DOI] 10.1096/fj.202100431R PMC 바로가기 [Article Type] Article
Surfactant for the Treatment of ARDS in a Patient With COVID-19COVID-19 환자의 ARDS 치료를 위한 계면활성제Case Reports Published on 2021-07-012022-09-11 Journal: Chest [Category] SARS, 치료법, 치료제, [키워드] ARDS Atypical benefit catalyst Clinical improvement COVID-19 deficiency distress Hypoxemia lung mechanics Neonatal Oxygenation Patient patient with COVID-19 patients with COVID-19 preserved respiratory distress Respiratory distress syndrome respiratory symptoms secondary to severe respiratory symptom severe respiratory symptoms shown surfactant syndrome the patient Treatment with COVID-19 [DOI] 10.1016/j.chest.2021.01.028 PMC 바로가기 [Article Type] Case Reports