Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19Research Published on 2021-08-162022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] Admission Analysis analyzed Biomarker Care center city classification Clinical data Coronavirus disease 2019 Course COVID-19 COVID-19 patient Critical critical COVID-19 patient critical COVID-19 patients CRP level ELISA endothelial endothelial injury Factor FIVE glycocalyx high mortality intensive care laboratory data LDH no significant difference pathogenesis of COVID-19 Platelet required Result selected severe COVID-19 severe COVID-19 patient severe respiratory failure severity severity of COVID-19 significant difference significantly significantly higher SOFA score Syndecan-1 Temporal therapeutic target two groups university Yokohama [DOI] 10.1186/s12959-021-00308-4 PMC 바로가기 [Article Type] Research
A possible pathogenic role of Syndecan-1 in the pathogenesis of coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 발병기전에서 신데칸-1의 가능한 병원성 역할Comparative Study Published on 2021-08-012022-09-11 Journal: International immunopharmacology [Category] 바이오마커, [키워드] Admission Analysis change changes in conditions control group coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRP demonstrated diagnosed with COVID-19 Disease activity gradually increased healthy healthy subject ICU ICU patient ICU Patients IL-10 IL-18 IL-6 indicated inflammatory markers investigated Iran marker non-ICU non-ICU patient non-ICU patients Pathogenesis pathogenic respiratory respiratory viral infection ROC Curve SARS-CoV-2 serum significantly higher significantly increased significantly lower Syndecan-1 Tehran the disease two groups Viral viral infection with COVID-19 [DOI] 10.1016/j.intimp.2021.107684 PMC 바로가기 [Article Type] Comparative Study
Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfateResearch Article Published on 2021-06-062022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] ACE2 addition binding block Cell cellular clinical parameter COVID-19 decrease epithelial cell epithelial cells explain expressed expression glycoprotein heparan sulfate host cells human lung hypoxia indicate infection rate inhibit inhibited Interaction lactoferrin lung modulating NRP1 offer pathophysiology pathway Prevent protein level RBD receptor reduce reduced reduction SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Syndecan-1 the RBD the receptor-binding domain the S1 subunit the spike protein therapeutic Treatment VERO E6 cells [DOI] 10.1080/22221751.2021.1932607 PMC 바로가기 [Article Type] Research Article
Possible involvement of Syndecan-1 in the state of COVID-19 related to endothelial injuryCase Report Published on 2021-01-272022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] acute respiratory syndrome Biomarker Case report changes in Chest Coronavirus infection COVID-19 Critically ill patient D-dimer Day decrease diagnosed disease endothelial Endothelial glycocalyx endothelial injury gradually increased ground glass opacities hospital Hospitalization increase in intensive care PaO Patient patient with COVID-19 reflected serum Syndecan-1 the disease thrombosis tomography transferred ventilator with COVID-19 withdrawn [DOI] 10.1186/s12959-021-00258-x PMC 바로가기 [Article Type] Case Report
Vascular Endothelial Glycocalyx Damage in COVID-19Review Published on 2020-12-192022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome cardiovascular disease caused Clarifying condition conditions coronavirus COVID-19 COVID-19 patients damage diabetes elevated endothelial Endothelial dysfunction endothelial function glycocalyx high affinity high-risk patient hypertension infecting Infection mechanism New coronavirus obesity Pandemics Patient Predictive prognostic indicator severe complication severe COVID-19 suggested Syndecan-1 systemic inflammatory-reactive microvascular endotheliopathy (SIRME) Vascular vascular endothelial dysfunction vascular endothelial glycocalyx (VEGLX) Vascular endothelium virus with COVID-19 [DOI] 10.3390/ijms21249712 PMC 바로가기 [Article Type] Review
Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial ApoptosisArticle Published on 2016-08-012023-06-24 Journal: American Journal of Respiratory and Critical Care [Category] 신종인플루엔자, [키워드] c-Met Influenza Lung injury Proteoglycan Syndecan-1 [DOI] 10.1164/rccm.201509-1878OC PMC 바로가기
Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial우간다의 중증 말라리아 아동에서 임상 시험에 참여한 내피세포 활성화, 지혈 및 혈전증 바이오마커Research Published on 2016-02-022024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] angiopoietins endothelial activation malaria Syndecan-1 von Willebrand factor [DOI] 10.1186/s12936-016-1106-z PMC 바로가기 [Article Type] Research