synergy – Page 2 – Communicable Diseases Research

Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells

SARS-CoV-2 세포로의 진입을 완전히 차단하려면 Vacuolar-ATPase 및 TMPRSS2의 이중 억제가 필요합니다

Article

Published on 2022-07-192022-09-11
Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 유전자 메커니즘,

Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations

용도 변경 구충제 조합의 상승적 항 SARS-CoV-2 활성

Article

Published on 2022-06-182022-09-11
Journal: BMC Pharmacology & Toxicology [Category] COVID19(2023년), SARS, 신약개발, 치료제,

[키워드] Analysis anti-parasitic drug Anti-parasitic drugs Anti-SARS-CoV-2 Activity antiviral drug antiviral drugs approach benefit Calu Calu-3 calu-3 cells Chloroquine claimed clinical trials Combination combinations country COVID-19 pandemic demonstrated drug drug combination drug combinations drugs Economy effective Effectiveness ENhance epithelial cells evaluated Health Service highest in vitro inhibitory inhibitory concentration Ivermectin Lung epithelial cells niclosamide pandemic reduction in Repurposed drug repurposing resulting SARS-CoV-2 shown Spread synergistic synergy tested Treatment vaccination Vero E6 Vero E6 cell VERO E6 cells
[DOI] 10.1186/s40360-022-00580-8 PMC 바로가기 [Article Type] Article

Lethal synergy between SARS-CoV-2 and Streptococcus pneumoniae in hACE2 mice and protective efficacy of vaccination

hACE2 마우스에서 SARS-CoV-2와 Streptococcus pneumoniae 간의 치명적인 시너지 효과와 예방 접종의 보호 효능

Article

Published on 2022-06-082022-09-12
Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, 폐렴구균 감염증,

HIV and COVID-19 co-infection: A mathematical model and optimal control

Research article

Published on 2022-05-302022-10-05
Journal: Informatics in Medicine Unlocked [Category] 변종,

[키워드] Analysis asymptotic basic reproduction number carried Co-infection controls COVID-19 driven by effective Endemic HIV HIV prevention HIV/AIDS Intervention Local mathematical MATLAB measure Measures opportunistic infection Optimal control optimization reduce significantly South Africa stability synergy Treatment with COVID-19
[DOI] 10.1016/j.imu.2022.100978 [Article Type] Research article

Cytokines from Bench to Bedside: A Retrospective Study Identifies a Definite Panel of Biomarkers to Early Assess the Risk of Negative Outcome in COVID-19 Patients

벤치에서 병상까지 사이토카인: 코로나19 환자에서 음성 결과의 위험을 조기에 평가하기 위한 확실한 바이오마커 패널을 확인하는 후향적 연구

Observational Study

Published on 2022-04-272022-09-11
Journal: International Journal of Molecular Sciences [Category] 바이오마커, 임상,

[키워드] affected age anti-inflammatory response Bench best Biomarker Biomarkers C-reactive protein conducted correlations COVID-19 COVID-19 patient COVID-19 patients CRP cut-off cytokine Cytokines death Definite disease pathogenesis Endothelial dysfunction explain Extensive help Hospital admission Hospitalized identify IL-10 IL-1β IL-6 IL-8 immunoparalysis interferon interferon-γ interleukin interleukin 6 Intervention intubation IP10 majority marker mortality rate MR-proADM negative observational study orotracheal intubation outcome Panel Patient performed Predictive Predictive value proadrenomedullin Prognosis representing retrospective risk severe patients sIL2Rα. Stage statistical analysis synergy systemic inflammation tested TNFα variable worse prognosis
[DOI] 10.3390/ijms23094830 PMC 바로가기 [Article Type] Observational Study

Anti-tuberculosis treatment strategies and drug development: challenges and priorities

Reviews

Published on 2022-04-272022-10-05
Journal: Nature reviews. Microbiology [Category] 바이오마커, 진단,

Triple-Probe DNA Framework-Based Transistor for SARS-CoV-2 10-in-1 Pooled Testing

SARS-CoV-2 10-in-1 풀링 테스트를 위한 트리플 프로브 DNA 프레임워크 기반 트랜지스터

Article

Published on 2022-04-272022-09-11
Journal: Nano Letters [Category] COVID19(2023년), SARS, 치료기술, 치료제,

Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2

렘데시비르-이버멕틴 조합은 SARS-CoV-2에 대한 개선된 시험관 내 활성과 상승적인 상호작용을 나타냅니다

Article

Published on 2022-03-012022-09-11
Journal: International journal of antimicrobial agents [Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral activity approved Combination combination therapy combination treatment coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 CPE Cytopathic activity demonstrated drug Drug administration drug resistance effective Efficacy food greater in vitro in vitro activity in vivo Interaction Ivermectin management mechanism offer reduce Remdesivir reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Support synergistic synergistic action synergy therapeutic therapeutic index to define Treatment strategies US Food and Drug Administration
[DOI] 10.1016/j.ijantimicag.2022.106542 PMC 바로가기 [Article Type] Article

Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE activity, and COVID-19: A rather controversial hypothesis. A case-control study

안지오텐신전환효소 삽입/제거 다형성, ACE 활성, 그리고 코로나19: 다소 논란의 여지가 있는 가설. 사례 대조 연구

Article

Published on 2022-03-012022-09-11
Journal: Journal of medical virology [Category] Fulltext, MERS, 변종, 유전자 메커니즘,

[키워드] ACE ACE activity ACE inhibitor ACE inhibitors ACE polymorphism allele alleles Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme. Angiotensin receptor blockers Angiotensin-converting enzyme arbitrary units carrier case-control study characterized complex conducted Control controls COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient disease severity enzyme epidemiological data expressed First wave Generalized linear model Genotype genotypes healthy individual healthy individuals Hypothesis I/D genotype increased risk individuals insertion insertion/deletion limit mechanism Patient Poisson regression polymorphism Prevalence recruited reduction Renin renin-angiotensin system retrospective risk factor risk ratio risk ratios RRs SARS-CoV-2 severe disease severity shown synergy therapy was used
[DOI] 10.1002/jmv.27417 PMC 바로가기 [Article Type] Article

Structure- and Interaction-Based Design of Anti-SARS-CoV-2 Aptamers

Anti-SARS-CoV-2 앱타머의 구조 및 상호 작용 기반 설계

Article

Published on 2022-02-242022-09-11
Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID19(2023년), SARS, 변종,

[키워드] approach aptamer Aptamers binding binding affinity blueprint complexes computational method Computational methods Cytometry develop Directed mutagenesis DNA docking drug design ENhance fragment molecular orbitals method functional IMPROVE in silico Infection Interaction iterative methodology molecular molecular docking molecular dynamics molecules Mutagenesis nucleic acids offer pathogen probes Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike protein SAXS scratch speed Spike protein Structure synergy target target protein tertiary structure the receptor-binding domain the SARS-CoV-2 time-consuming variants X-ray scattering
[DOI] 10.1002/chem.202104481 PMC 바로가기 [Article Type] Article