Nucleic acid biomarkers of immune response and cell and tissue damage in children with COVID-19 and MIS-CArticle Published on 2023-04-212024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] bisulfite sequencing cell damage cell-free DNA cell-free RNA Clinical severity Coronavirus disease 2019 disease biomarkers DNA damage host response immune response multisystem inflammatory syndrome in children nucleic acid sequencing pediatric RNA sequencing RNA-Seq SARS-CoV-2 signaling pathways Systems biology tissue damage whole-blood RNA [DOI] 10.1016/j.xcrm.2023.101034 PMC 바로가기 [Article Type] Article
Systems biology of disease tolerance to malariaArticle Published on 2023-03-312024-09-10 Journal: Future Microbiol [Category] 말라리아, [키워드] Data integration disease tolerance malaria metabolomics Systems biology transcriptomics PMC 바로가기
Network model integrated with multi-omic data predicts MBNL1 signals that drive myofibroblast activationArticle Published on 2023-03-272024-09-05 Journal: iScience [Category] update2024, [키워드] Cell Biology network modeling Systems biology [DOI] 10.1016/j.isci.2023.106502 PMC 바로가기 [Article Type] Article
Application of the PHENotype SIMulator for rapid identification of potential candidates in effective COVID-19 drug repurposingarticle Published on 2023-03-062024-09-05 Journal: Heliyon [Category] update2024, [키워드] 2DG, 2-Deoxy-Glucose ACE2, angiotensin-converting enzyme 2 Caco-2, Human colon epithelial carcinoma cell line Calu-3, Epithelial cell line Cellular host-immune response Cellular SARS-CoV-2 signatures Cellular simulation models COVID-19 COVID-19, Coronavirus disease 2019 DEGs, differentially expressed genes DEPs, Differentially expressed proteins Drug repurposing HCQ-CQ, (Hydroxy)chloroquine IFN, interferon ISGs, IFN-stimulated genes MITHrIL, Mirna enrIched paTHway Impact anaLysis MOI, multiplicity of infection MP, methylprednisolone NHBE, Normal human bronchial epithelial cells PHENSIM, PHENotype SIMulator SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Systems biology TLR, Toll-like receptor [DOI] 10.1016/j.heliyon.2023.e14115 PMC 바로가기 [Article Type] article
Safety by design: Biosafety and biosecurity in the age of synthetic genomicsarticle Published on 2023-02-102024-09-05 Journal: iScience [Category] update2024, [키워드] Biological sciences Genomics Systems biology [DOI] 10.1016/j.isci.2023.106165 PMC 바로가기 [Article Type] article
Integrated multiomics analysis to infer COVID-19 biological insightsarticle Published on 2023-01-312024-09-05 Journal: Burma Med J [Category] update2024, [키워드] metabolomics Proteins proteomics Systems biology [DOI] 10.1038/s41598-023-28816-5 PMC 바로가기 [Article Type] article
Mosquito host-seeking diel rhythm and chemosensory gene expression is affected by age and Plasmodium stages모기 숙주 탐색 일주기 리듬과 화학 감각 유전자 발현은 나이와 말라리아 단계에 의해 영향을 받는다.Article Published on 2022-11-052024-08-01 Journal: Burma Med J [Category] 말라리아, [키워드] Computational biology and bioinformatics Diseases Molecular biology Systems biology [DOI] 10.1038/s41598-022-23529-7 PMC 바로가기
Unpacking COVID-19 Systems Biology in Lung and Whole Blood with Transcriptomics and miRNA RegulatorsArticle Published on 2022-11-012023-07-10 Journal: Omics : a journal of integrative biology [Category] COVID19(2023년), [키워드] Biomarkers COVID-19 drug targets miRNAs Systems biology systems medicine [DOI] 10.1089/omi.2022.0104
Computational pharmacology: New avenues for COVID-19 therapeutics search and better preparedness for future pandemic crisesArticle Published on 2022-11-012022-11-16 Journal: Biophysical chemistry [Category] 신약개발, [키워드] affected Analysis approach Cheminformatics clinical clinical study clinical trials complex compounds COVID-19 COVID-19 pandemic COVID-19 therapeutics deep learning develop Disease progression drug Drug repurposing drugs effort global healthcare Health help identify in silico Infectious disease information Intervention lack limitation machine machine learning miRNA MONITOR New pandemic pharmacological strategy Regulatory Research robust Side-effects System Systems biology targets therapeutic therapeutic target Treatment strategies [DOI] 10.1016/j.bpc.2022.106891 PMC 바로가기
The SARS-CoV-2 targeted human RNA binding proteins network biology to investigate COVID-19 associated manifestationsArticle Published on 2022-09-302022-10-04 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] adopted Analysis antiviral property approach binding Brain Cancer caused clinical condition Comorbidity condition contribute coronavirus disease COVID-19 COVID-19 infection disease disorders effective FIVE human cancers human RNA identifying IMPROVE involved knowledge manifestation mechanism Medical conditions miRNA miRNAs molecular morbidity and mortality network neurodegeneration Neurological disorders nine pandemic Protein reported risk RNA RNA binding protein RNA binding proteins SARS-CoV-2 Systems biology target the SARS-CoV-2 virus with COVID-19 [DOI] 10.1016/j.ijbiomac.2022.07.200 PMC 바로가기 [Article Type] Article