Comparative Characterization and Risk Stratification of Asymptomatic and Presymptomatic Patients With COVID-19COVID-19 무증상 및 전증상 환자의 비교 특성 및 위험 계층화Comparative Study Published on 2021-07-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] 95% CI Admission Analysis Asymptomatic asymptomatic patient asymptomatic patients AUC case sery CD8+T cell characteristic characterization China Clinical characteristics Clinical management clinical symptom Clinical symptoms Comparative coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients demographics diagnosed Diagnosis differential diagnosis help Hospitalized Huoshenshan Hospital IMPROVE Laboratory no significant difference on admission outcomes Patient patients with COVID-19 presymptomatic presymptomatic patients Prognosis progression provided receiver operating characteristic receiver operating characteristic curve risk stratification single-cell single-center stratified symptomatic T cell exhaustion Wuhan [DOI] 10.3389/fimmu.2021.700449 PMC 바로가기 [Article Type] Comparative Study
CD8 + T Cell Responses during HCV Infection and HCCReview Published on 2021-03-022023-08-30 Journal: Journal of Clinical Medicine [Category] E형 간염, [키워드] CD8+ T cells checkpoint blockade therapy HCC HCV T cell exhaustion [DOI] 10.3390/jcm10050991 PMC 바로가기 [Article Type] Review
Recurrent Sepsis Exacerbates CD4 + T Cell Exhaustion and Decreases Antiviral Immune ResponsesOriginal Research Published on 2021-02-252023-06-08 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] adaptive immune system immune dysfunction recurrent sepsis secondary virus infection Sepsis T cell exhaustion [DOI] 10.3389/fimmu.2021.627435 PMC 바로가기 [Article Type] Original Research
Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal FluidArticle Published on 2020-12-232023-06-15 Journal: Immunity [Category] MERS, SARS, [키워드] cerebrospinal fluid COVID-19 interferon-stimulated genes neuro-COVID neurological manifestation SARS-CoV-2 Single-cell RNA sequencing T cell exhaustion transcriptomics [DOI] 10.1016/j.immuni.2020.12.011 PMC 바로가기 [Article Type] Article
Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19Research article Published on 2020-11-012022-10-05 Journal: Medical Hypotheses [Category] 치료법, [키워드] alleviate antioxidant characterized COVID-19 COVID-19 patient Cytokine storm disease dysregulated immune response dysregulation Effect Evidence Figuring immune dysregulation Inflammatory cytokine mitochondrial dysfunction MitoQ Potential treatment recent responsible SARS-CoV-2 severe COVID-19 Support T cell T cell exhaustion therapy [DOI] 10.1016/j.mehy.2020.110161 [Article Type] Research article
N-Acetylcysteine: A potential therapeutic agent for SARS-CoV-2Article Published on 2020-05-302023-06-15 Journal: Medical Hypotheses [Category] MERS, SARS, [키워드] coronavirus COVID-19 glutathione N-acetylcysteine NAC NLRP3 oxidative stress redox potential redox status SARS-CoV-2 T cell exhaustion TNF-ɑ [DOI] 10.1016/j.mehy.2020.109862 PMC 바로가기 [Article Type] Article
Pathogenetic Mechanisms of T Cell Dysfunction in Chronic HBV Infection and Related Therapeutic ApproachesReview Published on 2020-05-122023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Chronic HBV infection Immune-therapy immunoregulatory mechanisms liver environment T cell exhaustion [DOI] 10.3389/fimmu.2020.00849 PMC 바로가기 [Article Type] Review
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)코로나바이러스 질환 2019(COVID-19) 환자의 T 세포 감소 및 기능 소진Immunology Published on 2020-05-012022-09-06 Journal: Frontiers in Immunology [Category] Communicable Disease, COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antiviral immunity Care caused CD4 CD8 Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated count COVID-19 COVID-19 cases COVID-19 patient COVID-19 patients Critical cytokine cytokine strom Deterioration Exhaustion expression functional Health healthy controls high risk ICU IL-10 IL-6 Increasing intensive care unit Intervention laboratory-confirmed Laboratory-confirmed COVID-19 marker non-ICU non-ICU patients outbreak Patient patient survival PD-1 progressed reduced respiratory restored SARS- CoV-2 SARS-CoV-2 serum serum cytokine Serum IL-6 severe acute respiratory syndrome Coronavirus severe symptom significantly significantly higher stages surviving T cell symptomatic T cell T cell exhaustion T cell reduction T cells the disease TNF-α were measured [DOI] 10.3389/fimmu.2020.00827 PMC 바로가기 [Article Type] Immunology
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte DysfunctionImmunology Published on 2019-10-292022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] Cacna1f Activation Apoptosis B lymphocyte CaV1.4 calcium Cell channel chronic B cell activation chronic infections controls CRAC dysfunction effector memory elevated environmental condition event exacerbated example exhibited hallmark homeostasis Immune phenotype immune system immunological inhibitory receptor Inhibitory Receptors L-type L-type calcium channel marker maturation mice murine gammaherpesvirus 68 Mutation physiological reduced secondary messenger Signaling sustained T cell T cell exhaustion T cell memory T lymphocyte T lymphocytes TRP upregulation virus infection wild-type [DOI] 10.3389/fimmu.2019.02473 PMC 바로가기 [Article Type] Immunology
HBV Immune-Therapy: From Molecular Mechanisms to Clinical ApplicationsReview Published on 2019-06-052023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] Chronic HBV infection Immune-therapy T cell exhaustion [DOI] 10.3390/ijms20112754 PMC 바로가기 [Article Type] Review