DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanidarticle Published on 2023-06-282024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Antibiotics Bacteria Enzymes Pathogens Target identification [DOI] 10.1038/s41467-023-39300-z PMC 바로가기 [Article Type] article
Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccinesarticle Published on 2023-05-102024-09-05 Journal: Signal Transduction and Targeted Therapy [Category] update2024, [키워드] Infectious diseases Target identification Vaccines [DOI] 10.1038/s41392-023-01472-x PMC 바로가기 [Article Type] article
Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2article Published on 2023-05-052024-09-05 Journal: Burma Med J [Category] update2024, [키워드] Medicinal chemistry Target identification Theoretical chemistry Virtual drug screening [DOI] 10.1038/s41598-023-34189-6 PMC 바로가기 [Article Type] article
A machine learning method for the identification and characterization of novel COVID-19 drug targetsarticle Published on 2023-05-032024-09-05 Journal: Burma Med J [Category] update2024, [키워드] Drug safety machine learning Target identification [DOI] 10.1038/s41598-023-34287-5 PMC 바로가기 [Article Type] article
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrilsarticle Published on 2023-04-252024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Nucleoproteins peptides Protein aggregation Target identification X-ray crystallography [DOI] 10.1038/s41467-023-37865-3 PMC 바로가기 [Article Type] article
Small molecule metabolites: discovery of biomarkers and therapeutic targetsarticle Published on 2023-03-202024-09-05 Journal: Signal Transduction and Targeted Therapy [Category] update2024, [키워드] Drug screening structural biology Target identification [DOI] 10.1038/s41392-023-01399-3 PMC 바로가기 [Article Type] article
The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatmentarticle Published on 2023-03-162024-09-02 Journal: Cellular & molecular immunology [Category] 대상포진, [키워드] atopic dermatitis Biomarkers Diagnostic markers eczema Interleukins Predictive markers Target identification translational revolution [DOI] 10.1038/s41423-023-00992-4 PMC 바로가기 [Article Type] article
Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infectionarticle Published on 2022-05-122024-09-02 Journal: Burma Med J [Category] 대상포진, [키워드] Rheumatic diseases Target identification Target validation [DOI] 10.1038/s41598-022-11879-1 PMC 바로가기 [Article Type] article
Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanismArticle Published on 2022-04-062023-07-02 Journal: Scientific Reports [Category] COVID19(2023년), SARS, [키워드] SARS-CoV-2 Target identification Target validation [DOI] 10.1038/s41598-022-09664-1 PMC 바로가기 [Article Type] Article
Network medicine for disease module identification and drug repurposing with the NeDRex platformArticle Published on 2021-11-252022-10-04 Journal: Nature Communications [Category] 신약개발, [키워드] annotations approach approaches complex disease Computational platforms and environments Data integration databases disease drug Drug discovery drugs drugs targeting Efficacy faster FIVE Genes heterogeneous independent mechanism mechanisms network pathway platform provide Registered repurposing researcher specific disease statistical Target identification targets timelines Traditional unmet need utility [DOI] 10.1038/s41467-021-27138-2 PMC 바로가기 [Article Type] Article