Enhancing COVID Rehabilitation with Technology (ECORT): protocol for an open-label, single-site randomized controlled trial evaluating the effectiveness of electronic case management for individuals with persistent COVID-19 symptomsArticle Published on 2022-09-022022-10-04 Journal: Trials [Category] SARS, 임상, 치료제, [키워드] acute infection addition asked assessment Blended care breathlessness Care chronic condition Cognitive impairment Complete connection Course COVID COVID patient COVID-19 decrease determine disability ECM Effectiveness Electronic case management Enhancing evaluate Evidence fatigue Follow-up group Health help implementation IMPROVE individual Infection Intervention Long Long COVID majority management measure mental health morbidity National Open-label outcome outcomes participant persistent COVID-19 symptom platform Post-COVID rehabilitation. Prevalence Primary outcome protocol Randomized Randomized controlled trial receive rehabilitation resources Result SARS-CoV-2 scale severity Shortness of breath subset suggested Symptom Symptoms technology the WHO total score Treatment treatment guideline Trial usual care while [DOI] 10.1186/s13063-022-06578-1 PMC 바로가기 [Article Type] Article
A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox OutbreakArticle Published on 2022-08-252022-11-15 Journal: Viruses [Category] Fulltext, 원숭이두창, 진단, 치료제, [키워드] animal antivirals approved benefit Canada clinical study COVID-19 development disease dosage drug drug combination drug resistance Efficacy EMA European Medicines Agency food forms Health Canada highlight infections injection Interaction literature literature review Monkeypox MOST non-human primate off-label orthopoxvirus outbreak parameters Patent patents. pharmacokinetic regulatory agency rule SIGA-246 technology tecovirimat TPOXX treat Treatment United State USA Viral diseases website [DOI] 10.3390/v14091870 PMC 바로가기
SARS-CoV-2-positive patients display considerable differences in proteome diversity in urine, nasopharyngeal, gargle solution and bronchoalveolar lavage fluid samplesSARS-CoV-2-양성 환자는 소변, 비인두, 양치액 및 기관지폐포 세척액 샘플에서 단백질체 다양성에 상당한 차이를 나타냅니다.Article Published on 2022-08-082022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BALF Beijing Bronchoalveolar lavage fluid center chance change characterized Charle China collected coronavirus coronavirus 2 database demonstrated Department downloaded followed by gargle gargle solution Germany Human human body in urine individual infected with SARS-CoV-2 Infection information investigated Mayo Clinic Medicine nasopharyngeal nasopharyngeal sample Nasopharyngeal samples pathology peptide Protein Proteins proteome proteomic proteomics respiratory SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 virus SARS-CoV-2 viruses SARS-CoV-2-positive patient SARS-CoV-2-positive patients Science secreted seropositive individuals Severe acute respiratory syndrome significantly more solution status technology the SARS-CoV-2 virus UniProt unique university Urine USA virus viruses was used while [DOI] 10.1371/journal.pone.0271870 PMC 바로가기 [Article Type] Article
Simulated RBC antibody identification training panels created using SARS-CoV-2 kodecytes and immune plasmaSARS-CoV-2 kodecytes 및 면역 혈장을 사용하여 만든 시뮬레이션된 RBC 항체 식별 교육 패널Article Published on 2022-08-012022-09-12 Journal: Transfusion [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accuracy antibody antibody screening autoantibody can be used Cell competent develop Donor evaluated feasibility Frequency gel IgG IgG antibody immune Kodecyte maintain manual peptide plasma plasma sample platform positive Practical training Precision profile RBC Reactions required SARS-CoV-2 SARS-CoV-2 antibodies technology tested training unmodified cell warm [DOI] 10.1111/trf.17004 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of the FINLAY-FR-1A vaccine in COVID-19 convalescent participants: an open-label phase 2a and double-blind, randomised, placebo-controlled, phase 2b, seamless, clinical trialCOVID-19 회복기 참가자에 대한 FINLAY-FR-1A 백신의 안전성 및 면역원성: 공개 라벨 2a상 및 이중 맹검, 무작위 배정, 위약 대조, 2b상, 심리스, 임상 시험Clinical Trial Published on 2022-08-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 95% CI adverse event All participants Alpha anti-RBD antibody assigned Asymptomatic Beta clinical clinical trial clinical trials Complete control group control groups convalescent convalescent individual convalescent individuals COVID-19 criteria Cuba defined delta variant Delta variants dimeric double-blind education elicited ELISA Endpoint enrolled Environment evaluate evaluated experimental group first stage geometric mean geometric mean titre geometric mean titres greater hematology ICTRP IgG antibodies immune response immunogenicity immunology increase in injected injection injection site Intervention intervention group Mild minor Moderate COVID-19 natural immunity Negative PCR neutralisation test neutralising antibody Occurrence Open-label Pain participant Participants PCR test per-protocol population Phase 1 Phase 2 Placebo placebo group placebo-controlled prevaccination Primary outcome Primary outcomes Public randomised Randomly Receptor binding domain recruited Registered registry reported Safety safety analysis safety population safety profile SARS-CoV-2 Science seamless secondary Secondary endpoints Serious Adverse Event Serious Adverse Events seroconversion rate sexual single dose stages study population technology the placebo group titre Trial two groups vaccination Vaccine vaccine immunogenicity Virus neutralisation Volunteer was done WHO-ICTRP [DOI] 10.1016/S2213-2600(22)00100-X PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 variants inactivation of plasma units using a riboflavin and ultraviolet light-based photochemical treatmentArticle Published on 2022-08-012022-11-15 Journal: Transfusion and apheresis science : official journ [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] blood product Cell cells Convalescent plasma donor COVID-19 patients Critically ill Culture experiments highlight Human plasma inactivated inactivation infect Infection infectious titer limit of detection material Neutralizing antibodies pathogen Pathogen reduction photochemical plasma Plasma transfusion therapy plasma unit reduced reducing reduction in Riboflavin RT-PCR SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant technology Test therapy tissue Treatment ultraviolet ultraviolet light USA UV light variants of concern. VERO E6 cells viral strain virus virus virus titer [DOI] 10.1016/j.transci.2022.103398 PMC 바로가기
Pasos Hacia La Salud II: study protocol for a randomized controlled trial of a theory- and technology-enhanced physical activity intervention for Latina women, compared to the original interventionPasos Hacia La Salud II: 원래 개입과 비교하여 라틴계 여성을 위한 이론 및 기술 강화 신체 활동 개입의 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-08-012022-09-11 Journal: Trials [Category] 임상, [키워드] activity adaptation age approach ARMS assessments baseline baseline assessments benefit build change chronic disease Chronic diseases clinical Complete COVID-19 pandemic described dissemination Effect Efficacy eHealth enhanced equity exercise exploratory feature female greater Health health benefits Health promotion help helping Hispanic increased risk increases in intent-to-treat interactions Intervention intervention effect Intervention effects Latina linear long term maintain manuscript mHealth mHealth. outcome participant physical activity physically Population proportion Randomized Randomized controlled trial recruited Regression model Research secondary outcome Self-efficacy Social support Study protocol Support technology treat website women [DOI] 10.1186/s13063-022-06575-4 PMC 바로가기 [Article Type] Article
Clinical and genomic signatures of SARS-CoV-2 Delta breakthrough infections in New York뉴욕에서 SARS-CoV-2 Delta 획기적인 감염의 임상 및 게놈 서명Article Published on 2022-08-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] adaptive age Alpha Analysis Breakthrough infection breakthrough infections center circulating variant circulating variants clinical clinical variables confounders contributed controls COVID-19 hospitalization death Delta determinant distribution Epidemic Genome genomic Genomic signatures of vaccine breakthrough growth Hospitalization increasingly individuals Infection Isaac Mutation network network analysis Network analysis of clinical variables New York Nsp12 occurred parameters Phylogenetic predominant prevented profiles SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variant of concern (VOC) delta Selective adaptation significantly spike spike mutation Spike S112L and nsp12 F192V Support supported technology time Time since vaccination. vaccination Vaccine vaccine breakthrough infection vaccine breakthrough infections viruses VoC while [DOI] 10.1016/j.ebiom.2022.104141 PMC 바로가기 [Article Type] Article
Nanoscale Technologies in the Fight against COVID-19: From Innovative Nanomaterials to Computer-Aided Discovery of Potential Antiviral Plant-Derived DrugsCOVID-19와의 싸움에서 나노스케일 기술: 혁신적인 나노물질에서 잠재적인 항바이러스 식물 유래 약물의 컴퓨터 지원 발견까지Review Published on 2022-07-302022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Antiviral antiviral activity computational approach develop drug drug delivery systems identify increasingly measure Measures molecular molecular docking nanodecoys Nanomaterial nanomaterials nanosystems Pandemics Pathways penetration Potential reducing SARS-CoV-2 SARS-CoV-2 cell technology terpenoids therapeutic agents virus spread virus spread control measures. [DOI] 10.3390/biom12081060 PMC 바로가기 [Article Type] Review
Correlation Analysis of Positive Therapy Based on High Content Image Analysis Technology on Posttraumatic Nerve Growth in Patients with COVID-19 in the Context of Intelligent Medical TreatmentRandomized Controlled Trial Published on 2022-07-192022-10-05 Journal: Contrast media & molecular imaging [Category] COVID19(2023년), SARS, 임상, [키워드] active treatment Anxiety content Context control group Coronavirus pneumonia correlation crown Depression Diseases disorder early recovery Effect eliminating emotional evaluated growth hospital Image incidence incidence rate introduced Isolation maintain Mental disorder negative emotions nerve novel Novel coronavirus observation Patient patients Pneumonia positive Posttraumatic Stress promote Psychological PTSD randomly divided reduced rehabilitation selected significantly technology therapy treated Treatment with COVID-19 Wuhan [DOI] 10.1155/2022/9165764 PMC 바로가기 [Article Type] Randomized Controlled Trial