Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosisArticle Published on 2022-09-272022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] accompanied acute respiratory distress addition Comorbidity coronavirus disease COVID-19 COVID-19 pathology cytokine production decrease dysregulated immune response effective Efficacy Evidence functions glycyrrhiza Glycyrrhiza glabra Hamster model hamsters hypercoagulable IL-17A IL-4 immunocompromised individuals immunomodulator immunomodulatory properties Inflammatory cytokine ingredient Lung pathology lung viral load mice mice and human neutrophil functions. mitigate Mortality mRNA expression murine NET NETosis neutrophil polymorphonuclear neutrophil pro-inflammatory cytokine Protective provide Pulmonary pathology reduced reducing robust ROS SARS-CoV-2 SARS-COV-2 infection skewed suppress syndrome Th17 Th2 Th2/Th17 differentiation Treatment vaccination Vaccine variant [DOI] 10.3389/fimmu.2022.945583 PMC 바로가기
Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral ClearanceArticle Published on 2022-09-022022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] antibody B cell basophils CD4 T cells CD4+ CD4+ T cell CD4+ T cells cellular component correlated count COVID-19 Critical cytokine profile Delayed determinant disease deterioration help hospitalised patient Humoral response IL-9 immune activation immune parameter less longitudinal design magnitude MIF moderate Monocytes naïve naïve CD4+ T cell neutralising Neutralising Antibodies Neutrophils pro-inflammatory risk stratification SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease T cell Th2 the timing tissue damage viral clearance [DOI] 10.3390/cells11172743 PMC 바로가기
A Novel Single-Stranded RNA-Based Adjuvant Improves the Immunogenicity of the SARS-CoV-2 Recombinant Protein VaccineArticle Published on 2022-08-242022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] activate acute respiratory syndrome adjuvant adjuvants aluminum China Combination coronavirus CpG effective elevated Emergency use authorization Genome hydroxide immune immune response immunogenicity Innate immunity levels of antibody mice Neutralizing antibody titer novel novel adjuvant omicron Protein RBD Receptor binding domain recombinant recombinant RBD protein Research SARS-CoV-2 SARS-CoV-2 recombinant protein vaccine signaling pathway single-stranded single-stranded RNA-based adjuvant. subunit Th1 Th2 the antibody response the SARS-CoV-2 Vaccine was used ZF2001 [DOI] 10.3390/v14091854 PMC 바로가기
RBD decorated PLA nanoparticle admixture with aluminum hydroxide elicit robust and long lasting immune response against SARS-CoV-2수산화알루미늄이 포함된 RBD 장식 PLA 나노입자 혼합물은 SARS-CoV-2에 대한 강력하고 오래 지속되는 면역 반응을 이끌어냅니다.Article Published on 2022-07-012022-09-12 Journal: European journal of pharmaceutics and biopharmaceu [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome aluminum antibody Antibody Response Antigen binding caused Characteristics circumvent Combination coronavirus COVID-19 COVID-19 vaccine develop E. coli elicit elicited expressed expression generate global pandemic hydroxide immune response immunization lactic acid limitations long-lasting mammalian memory Memory antibody response mimicking neutralization neutralize plaque Polymeric nanoparticles Protein-subunit vaccine provided RBD Receptor binding domain Result robust SARS-CoV-2 SARS-CoV-2 vaccine secondary antibody subunit Subunit vaccine Th1 Th2 Vaccine vaccine production virus infection Virus neutralization [DOI] 10.1016/j.ejpb.2022.05.008 PMC 바로가기 [Article Type] Article
Th1 cytokine endotype discriminates and predicts severe complications in COVID-19Article Published on 2022-06-012022-11-15 Journal: European cytokine network [Category] 바이오마커, 유전자 메커니즘, [키워드] accompanied Analysis anti-inflammatory treatment association C-reactive protein CCL17 Cell-mediated immunity characterized clinical feature Clinical outcome Cluster Clustering coronavirus disease COVID-19 COVID-19 case COVID-19 patients Critical case CRP CXCL9 decrease disease effector T cell highlight IL-10 IL-18 IL-6 increase in Inflammatory marker investigated mechanism Mild moderate mononuclear cells multiplex immunophenotyping pathology pathophysiology Patient Peripheral blood predict Prevent Prognosis prognostic proportion public health reflected reported serum cytokine severe complication severe COVID-19 severity single-cell systemic inflammatory markers T cell T cell exhaustion. Th1 Th1 cytokine Th1 inflammation Th2 Treatment [DOI] 10.1684/ecn.2022.0477 PMC 바로가기
Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석Clinical Trial Published on 2022-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제, [키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19 [DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial
Characterization of Immune Response Diversity in Rodents Vaccinated with a Vesicular Stomatitis Virus Vectored COVID-19 Vaccine수포성 구내염 바이러스 벡터가 적용된 COVID-19 백신을 접종한 설치류의 면역 반응 다양성 특성화Article Published on 2022-05-242022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome Administered animal model animal models applied BALB/c mice candidate Cellular immune response cellular immunity challenge characterization coronavirus coronavirus disease COVID-19 COVID-19 vaccine Diversity effective Efficacy evaluated hamsters humoral immune response immune response immunization immunization routes intramuscular intranasal Neutralizing neutralizing antibody Protective protective immunity provide public health recombinant COVID-19 vaccine recombinant vesicular stomatitis virus reflect response robust rodent SARS-CoV-2 significantly higher stomatitis susceptible Syrian Golden hamsters T cell Th1 Th2 triggered Vaccine vaccine candidate vesicular vesicular stomatitis virus VSV [DOI] 10.3390/v14061127 PMC 바로가기 [Article Type] Article
Comparison of immune responses induced by two or three doses of an alum-adjuvanted inactivated SARS-CoV-2 vaccine in mice마우스에서 명반 면역증강제가 첨가된 비활성화 SARS-CoV-2 백신의 2~3회 투여에 의해 유도된 면역 반응의 비교Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adjusting alum alum-adjuvanted inactivated SARS-CoV-2 vaccine Analysis antibody BNT162b2 boost CD4+ CD8+ Cell-mediated immunity cellular cellular immunity clinical trials coronavirus dose doses Heterologous homologous humoral Humoral response humoral responses IgG responses immune response immune responses immunization immunization schedule immunization schedules inactivated memory mice offer respiratory response SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines second dose severe acute respiratory syndrome Coronavirus significantly spike-specific cellular immunity spike-specific IgG T cell T cell response tested Th2 Vaccine development variant [DOI] 10.1002/jmv.27637 PMC 바로가기 [Article Type] Article
Th2-Oriented Immune Serum After SARS-CoV-2 Vaccination Does Not Enhance Infection In VitroSARS-CoV-2 백신 접종 후 Th2 지향 면역 혈청은 시험관 내 감염을 증가시키지 않습니다Article Published on 2022-04-082022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] accompanied acute respiratory syndrome ADE Adjustment adjuvant aluminum aluminum adjuvant Antibody-dependent enhancement antibody-dependent enhancement of infection Antigen cell line coronavirus Efficacy examined expression pattern Fc receptors Human immune Immune cell immunization immunopathology in vitro inactivated Inactivated SARS-CoV-2 vaccine Infection infiltration lung MERS-CoV mice Middle East neutralizing antibody Neutralizing antibody titer preclinical study Pseudotyped virus respiratory syndrome coronavirus response risk S1 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 virus sera serum Spike protein spike protein subunit vaccine. subunit T helper tested Th2 the SARS-CoV-2 Vaccine virus [DOI] 10.3389/fimmu.2022.882856 PMC 바로가기 [Article Type] Article
The Role of Vitamin D in COVID-19 and the Impact of Pandemic Restrictions on Vitamin D Blood ContentPharmacology Published on 2022-02-212022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Anti-inflammatory antiviral action content COVID-19 COVID-19 infection Cytokine storm dendritic cells Evidence expected help immune system Impact indicated Infection Infectious disease Inflammatory inhibit macrophages mechanism microbial infections pandemic pro-inflammatory Th1 reduce regulate reported respiratory tract response restriction risk of COVID-19 role SARS-COV-2 infection SARS-CoV2 severe pneumonia shown Support switching Symptoms T cells Th17 Th2 Transcription treat treating SARS-CoV-2 infection Treg Vitamin D Vitamin D supplementation [DOI] 10.3389/fphar.2022.836738 PMC 바로가기 [Article Type] Pharmacology