the cell – Page 2 – Communicable Diseases Research

A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection

새로운 글루코코르티코이드 및 안드로겐 수용체 조절제는 SARS-CoV-2 감염의 시리아 햄스터 모델에서 바이러스 진입 및 선천성 면역 염증 반응을 감소시킵니다

Immunology

Published on 2022-02-162022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제,

Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design

퓨린 억제제로서 COVID-19에 대응하는 ta-Defensins: 인실리코 효율성 예측 및 새로운 화합물 설계

Research Article

Published on 2022-02-092022-09-11
Journal: Computational and Mathematical Methods in Medicine
[Category] MERS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Anti-inflammatory antigenicity antimicrobial peptide antimicrobial peptides arginine bind binding binding site caused Cell cell membrane characterized Compound coronavirus coronavirus disease Coronavirus disease 2019 counter COVID-19 COVID-19 infection Defense defense mechanisms defensin docking docking analysis drug candidate drug candidates Efficiency electrostatic enzyme event furin furin inhibitors Health Organization in silico approaches in vitro in vivo infect Inflammatory inhibit investigated mechanism mechanisms molecules novel pandemic peptide peptides Potential treatment prediction respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein Spike proteins stability Stage subclass the cell the spike protein therapeutic unique WHO World Health Organization
[DOI] 10.1155/2022/9735626 PMC 바로가기 [Article Type] Research Article

Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease

ACE, ACE2, AGTR1 유전자 및 COVID-19 질병의 중증도의 다형성

Research Article

Published on 2022-02-042022-09-10
Journal: PLoS ONE
[Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] 95%CI ACE ACE gene ACE2 ACE2 protein admitted to ICU age AGTR1 Analysis analyzed angiotensin association Cancer Cell Clinical course collected Comorbidities Comorbidity Course COVID-19 disease COVID-19 infection COVID-19 patient COVID-19 patients death death group Deceased demonstrated diabetes disease distribution evidenced exaggerated inflammatory response expected G/A Gender Genetic Genetic variant Genotype greater Hardy-Weinberg equilibrium Hospitalization Hospitalized Human hypertension I/D ICU increased risk increased the risk Infection inheritance intensive care unit lead Lung disease male marker modulate multivariable multivariable analysis nucleotide obesity Older age Outpatient outpatients patients with comorbidities patients with COVID-19 produced protector recessive model regulator Renin renin-angiotensin system Result risk rs1978124 rs2285666 SARS-CoV-2 SARS-CoV-2 virus selected severity severity of COVID-19 Severity of disease Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility susceptibility to infection the cell the disease the severity group virus while
[DOI] 10.1371/journal.pone.0263140 PMC 바로가기 [Article Type] Research Article

Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytes

Article

Published on 2022-01-282022-10-04
Journal: Communications Biology
[Category] 바이오마커,

Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective

COVID-19의 잠재적 치료에 대한 접근: 의약 화학 관점의 일반 개요

Review

Published on 2022-01-202022-09-10
Journal: Molecules
[Category] SARS, 변종, 치료제,

[키워드] 3CLpro inhibitors active against affected Anti-inflammatory antibody Antiviral arising Cell characteristic charge Chemistry corticoids Corticosteroids COVID-19 pandemic cytokine Cytokine storm drug drugs targeting elongation factor Genome host cell host protein host proteins hyperinflammatory phase IL6 antibodies Inflammatory interleukin interleukin 6 involved Jak JAK-STAT inhibitors kinases less Mutation pharmacological treatment pharmacological treatments polyprotein Potential protease Protein RdRp inhibitors S antibodies SARS-CoV-2 SARS-CoV2 serine protease inhibitors sphingosine SphK2 inhibitors stages target the cell the disease therapeutic intervention triggered vaccination variants Viral viral entry viral genome viral infection Viral proteins virus
[DOI] 10.3390/molecules27030658 PMC 바로가기 [Article Type] Review

Direct comparison of different therapeutic cell types susceptibility to inflammatory cytokines associated with COVID-19 acute lung injury

COVID-19 급성 폐 손상과 관련된 염증성 사이토카인에 대한 다양한 치료 세포 유형 감수성의 직접 비교

Research

Published on 2022-01-152022-09-10
Journal: Stem Cell Research & Therapy
[Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome Alter Analysis ARDS ARDS patients Bone marrow Cell Cell therapy cell type cell viability cells characterized clinical evaluation clinical trial clinically Combination conditioned media COVID-19 COVID-19 ARDS patient cytokine Cytokine storm Cytokines Cytometry deleterious effect determine Direct Disease progression dose doses dysregulated immune response evaluate the effect excluded expression Extracellular Extracellular vesicles Flow flow cytometry greater high risk IL-6 immunomodulatory implicated Infection Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators mediators Mesenchymal stromal cells Mild Mortality not altered Novel coronavirus paracrine pathology Patient pro-inflammatory mediator pro-inflammatory mediators progression proteomic receptor receptors respiratory distress Respiratory distress syndrome Result severe ARDS severe COVID-19 stem cell stem cells stromal cells supplementary material survival susceptibility syndrome the cell therapeutic therapeutic efficacy therapy Treatment umbilical Vesicle viability were assessed widespread with COVID-19
[DOI] 10.1186/s13287-021-02699-7 PMC 바로가기 [Article Type] Research

The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein’s subcellular localization, palmitoylation and pseudovirus entry

SARS-COV-2 스파이크 (S)와 ZDHHC5/GOLGA7의 상호 작용 및 S 단백질의 세포 내 위치, 팔미 토일 화 및 슈도 바이러스 진입에 미치는 영향

Research

Published on 2021-12-272022-09-10
Journal: Virology Journal
[Category] SARS, 치료기술,

[키워드] A549 acute respiratory syndrome acute respiratory syndrome coronavirus Affect affected Affinity purification analyzed Antiviral APT2 assays Biotin Cas9 Cell cell line cell lines cell types cells co-immunoprecipitation co-IP Colocalization complex coronavirus CRISPR CRISPR-Cas9 cysteine cysteine residue determine domain Effect Efficiency endodomain enzymatic activity enzyme fluorescence microscopy GOLGA7 had no HEK293T HEK293T cell HEK293T cells Hela HeLa cells host protein host proteins independent independent of interact Interaction knowledge mass spectrometry no significant effect palmitoylation Protein provide pseudovirus entry reason Renilla Renilla luciferase respiratory Result S protein S proteins SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S protein SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant effect significantly Spike protein subcellular localization the cell the S protein virus entry virus infection Virus-host interaction ZDHHC5 ZDHHC5/GOLGA7
[DOI] 10.1186/s12985-021-01722-w PMC 바로가기 [Article Type] Research

Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples

감염성 예측: 임상 샘플에서 배양 가능한 SARS-CoV-2를 검출하기 위한 4가지 PCR 기반 분석 비교

Article

Published on 2021-12-132022-09-11
Journal: EMBO Molecular Medicine
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

[키워드] addition analytical sensitivity caused Cell cell type clinical clinical sample clinical samples correlated COVID‐19 CPE Culture Cutoff Cytopathic effect dependent on detect diagnostic diagnostic testing effective expressing faster Genome identify infected individuals infectious Infectious virus Isolation Live virus Methods & Resources Microbiology, Virology & Host Pathogen Interaction negative‐strand pandemic parental predict replicative RNA RT‐PCR RT–PCR SARS‐CoV‐2 SARS‐CoV‐2 sgRNA significantly specimen subgenomic subset tested the cell TMRPSS2 transcriptional transcripts Vero E6 Vero E6 cell VERO E6 cells Viral Viral RNA viral RNA species viral RNA specy virus
[DOI] 10.15252/emmm.202115290 PMC 바로가기 [Article Type] Article

Low-molecular-weight heparin use in coronavirus disease 2019 is associated with curtailed viral persistence: a retrospective multicentre observational study

코로나바이러스 질병 2019에서 저분자량 헤파린 사용은 바이러스 지속성 감소와 관련이 있습니다: 후향적 다기관 관찰 연구

Observational Study

Published on 2021-12-012022-09-10
Journal: Cardiovascular Research
[Category] SARS, 바이오마커, 임상,

[키워드] (cfDNA) 95% confidence interval anticoagulation attenuation Biomarker cell death cell-free DNA cfDNA Chain Reaction Coagulopathy contraindications coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient COVID-19-associated coagulopathy D-dimer decrease different time point different time points Effect evaluate evaluated haemostasis hazard ratio heparin Hospitalization Hospitalized hospitalized COVID-19 patient hypercoagulability interquartile interquartile range LMWH Low-molecular-weight heparin marker mechanism Mortality multicentre multivariable Cox regression no effect NOAC oral anticoagulant outcome Patient patients with COVID-19 plasma polymerase chain polymerase chain reaction Quantitative quantitative polymerase chain reaction reduced reduction Region responsible retrospective SARS-CoV-2 viral persistence subset survival the cell Thromboinflammation time Viral viral persistence virus was collected
[DOI] 10.1093/cvr/cvab308 PMC 바로가기 [Article Type] Observational Study

Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology

폐암 모델, 중증 급성 호흡기 증후군 공개

Article

Published on 2021-11-012022-09-11
Journal: International Journal of Molecular Sciences
[Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE2 ACE2 expression acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition AXL bemcentinib bronchial organoids cancer cell lines caused Cell cell surface component coronavirus coronavirus disease Coronavirus disease 2019 Effects EGFR EMT epithelial cells expression growth healthy highlight host cell host cells increasingly induce infected cell infected cells infection with SARS-CoV-2 Infectious disease inhibitor investigated Kinase inhibitor lung cancer Model model system morbidity morbidity and mortality nasal epithelium NSCLC observation occur offer other respiratory virus Other respiratory viruses overexpression Pathogenesis pathogenesis of SARS-CoV-2 Patient Patients with cancer potential mechanism potential mechanisms reduction Regulation repressed respiratory respiratory distress Respiratory distress syndrome respiratory tracts respiratory viruses resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus surface protein the cell tight junction tissue tissues TMPRSS2 transcriptional transcriptional change transforming growth factor transition tyrosine tyrosine kinase inhibitor up-regulation variety viruses ZEB1 ZEB1.
[DOI] 10.1016/j.jtho.2021.07.002 PMC 바로가기 [Article Type] Article